佛山市顺德地区1746例食物不耐受结果分析
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摘要
目的分析佛山市顺德地区人群食物不耐受情况,为本地区过敏性疾病防治工作提供科学依据。方法采用酶联免疫吸附法(ELISA)检测1 746例食物不耐受患者血清中7种食物过敏原特异性IgG抗体水平,并根据各组(性别、年龄段、季节)进行分类统计,分析本地区患者食物不耐受情况。结果 1 746例食物不耐受患者中有911例出现食物不耐受特异性IgG抗体阳性,总阳性率为52.18%。按性别分类后统计,男性食物不耐受特异性IgG抗体总阳性率51.65%,女性食物不耐受特异性IgG抗体总阳性率52.80%,两者差异无统计学意义(P>0.05)。通过检测7种食物不耐受特异性IgG抗体水平,发现鸡蛋的不耐受特异性IgG抗体阳性率最高(33.96%),其次为牛奶、大豆。按年龄分类统计:童年组食物特异性IgG抗体阳性率最高(80.26%),其次为少年组、成年组,年龄分布差异有统计学意义(P<0.05)。三组中7种食物除虾之外,过敏原阳性率差异有统计学意义(P<0.05)。患者对一种、两种、三种以上食物不耐受阳性率差异有统计学意义(P<0.05),其中对一种食物不耐受阳性率最高。按季节分类统计:食物不耐受特异性IgG抗体阳性患者在季节分布上差异无统计学意义(P>0.05)。单因素和多因素的Logistic回归分析结果显示,白细胞和C-反应蛋白增多与食物不耐受显著相关,差异有统计学意义(P<0.05)。结论鸡蛋、牛奶是顺德地区食物不耐受的主要过敏原,童年组较多见,食物不耐受的阳性率与性别、季节分布无关,与白细胞和C-反应蛋白增多相关。通过本研究有助于对顺德地区人群食物不耐受进行健康的饮食指导。
Objective To provide scientific evidence for prevention and treatment of allergic diseases in Shunde region of Foshan city. Methods Seven food allergen-specific IgG antibodies were detected in serum of 1 746 patients who were tested for food intolerance in our hospital by enzyme-linked immunosorbent assay(ELISA). According to each group(gender,age,season),the classification and statistics were used to analyze the food intolerance of patients in this area.Results Among the 1 746 cases of food intolerance,911 cases were positive for food intolerance-specific IgG antibody,and the total positive rate was 52.18%. Classified by gender,the positive rate of food-specific IgG antibody in males was51.65%,and the positive rate of females food-specific IgG antibody was 52.80%. There was no significant difference between the positive rates of males and females(P>0.05).By detecting the levels of seven specific food intolerance-specific IgG antibodies,the egg-tolerant specific IgG antibody positive rate was the highest(33.96%),followed by milk and soybean.Classified by age,the positive rate of food-specific IgG antibodys in childhood group was the highest(80.26%),followed by juvenile group and adult group. The differences between age distribution were statistically significant(P<0.05).There was significant difference in the positive rate of specific IgG antibody in seven different food type apart from shrimp between different age groups(P<0.05).The differences in the positive rate of one,two and more than three food intolerances were statistically significant. Of which,the positive rate of one food intolerance was the highest(P<0.05). Classified by season,there was no significant difference in seasonal distribution between food-tolerant and specific IgG antibody-positive patients(P>0.05). Univariate and multivariate Logistic regression analysis showed that leukocyte and C-reactive protein increase were significantly correlated with food intolerance(P<0.05). Conclusion Eggs and milk were the main allergens of food intolerance in Shunde area. The food allergy were more common in children.The positive rate of food intolerance was not correlated with gender and seasonal distribution,but was positive associated with increased white blood cells and C-reactive protein. This study will help people in Shunde to have healthy diet guidance for food intolerance.
Objective To provide scientific evidence for prevention and treatment of allergic diseases in Shunde region of Foshan city. Methods Seven food allergen-specific IgG antibodies were detected in serum of 1 746 patients who were tested for food intolerance in our hospital by enzyme-linked immunosorbent assay(ELISA). According to each group(gender,age,season),the classification and statistics were used to analyze the food intolerance of patients in this area.Results Among the 1 746 cases of food intolerance,911 cases were positive for food intolerance-specific IgG antibody,and the total positive rate was 52.18%. Classified by gender,the positive rate of food-specific IgG antibody in males was51.65%,and the positive rate of females food-specific IgG antibody was 52.80%. There was no significant difference between the positive rates of males and females(P>0.05).By detecting the levels of seven specific food intolerance-specific IgG antibodies,the egg-tolerant specific IgG antibody positive rate was the highest(33.96%),followed by milk and soybean.Classified by age,the positive rate of food-specific IgG antibodys in childhood group was the highest(80.26%),followed by juvenile group and adult group. The differences between age distribution were statistically significant(P<0.05).There was significant difference in the positive rate of specific IgG antibody in seven different food type apart from shrimp between different age groups(P<0.05).The differences in the positive rate of one,two and more than three food intolerances were statistically significant. Of which,the positive rate of one food intolerance was the highest(P<0.05). Classified by season,there was no significant difference in seasonal distribution between food-tolerant and specific IgG antibody-positive patients(P>0.05). Univariate and multivariate Logistic regression analysis showed that leukocyte and C-reactive protein increase were significantly correlated with food intolerance(P<0.05). Conclusion Eggs and milk were the main allergens of food intolerance in Shunde area. The food allergy were more common in children.The positive rate of food intolerance was not correlated with gender and seasonal distribution,but was positive associated with increased white blood cells and C-reactive protein. This study will help people in Shunde to have healthy diet guidance for food intolerance.
引文
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[6]郑岚,杨蔺,王星.上海地区2 437例食物不耐受患儿过敏原谱检测分析[J].检验医学,2018,33(9):786-789.
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[9]沐阳,李兴华.肠易激综合征与食物不耐受相关性的研究现状[J].临床消化病杂志,2017,29(4):263-266.
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[11]张丽文,蒋瑾瑾.儿童再发性腹痛与食物不耐受及食物过敏的相关性研究[J].实用临床医药杂志,2017,21(7):85-88.
[12]王根在,李恒涛,查建忠,等.500例哮喘患儿主要过敏原分析及干预效果[J].热带医学杂志,2017,17(3):388-391.
[13]王燕,王伟,周静,等.食物不耐受与全身各系统相关性疾病关系研究进展[J].齐鲁医学杂志,2014,29(4):367-370.
[14]赵娟,吴秀娟,张德志,等.新疆地区965例过敏性疾病患者食物特异性IgG抗体检测分析[J].中国中西医结合皮肤性病学杂志,2018,17(2):133-136.
[15]Wilson K,Hill RJ.The role of food intolerance in functional gastrointestinal disorders in children[J].Aust Fam Physician,2014,43(10):686-689.
[16]Ortolani C,Pastorello EA.Food allergies and food intolerances[J].Best Pract Res Clin Gastroenterol,2006,20(3):467-483.
[17]刘春景,杨丽君,王思.湿疹患儿血清总IgE与特异性IgE检测及其相关性[J].中国临床研究,2017,30(12):1631-1633.
[2]Guo H,Jiang T,Wang J,et al.The value of eliminating foods according to food-specific immunoglobulin G antibodies in irritable bowel syndrome with diarrhoea[J].J Int Med Res,2012,40(1):204-210.
[3]Manuyakorn W,Tanpowpong P.Cow milk protein allergy and other common food allergies and intolerances[J].Paediatr Int Child Health,2018,17:1-9.
[4]Maitre S,Maniu CM,Buss G,et al.Food allergy or food intolerance[J]?Rev Med Suisse,2014,10(426):846-850,852-853.
[5]于淼琛,潘立阳,王凤.大连地区1 154例食物不耐受结果分析[J].实验与检验医学,2017,35(5):701-703.
[6]郑岚,杨蔺,王星.上海地区2 437例食物不耐受患儿过敏原谱检测分析[J].检验医学,2018,33(9):786-789.
[7]曾晓丽,纪智倩,蔡良奇.厦门地区1 049例患者食物不耐受特异性IgG抗体检测[J].中国卫生标准管理,2018,9(8):11-14.
[8]童红莉,贾兴旺.2 057例14岁以下儿童血清食物特异性IgG检测结果分析[J].标记免疫分析与临床,2017,24(2):127-129.
[9]沐阳,李兴华.肠易激综合征与食物不耐受相关性的研究现状[J].临床消化病杂志,2017,29(4):263-266.
[10]B?hn L,St?rsrud S,T?rnblom H,et al.Self-reported foodrelated gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life[J].Am J Gastroenterol,2013,108(5):634-641.
[11]张丽文,蒋瑾瑾.儿童再发性腹痛与食物不耐受及食物过敏的相关性研究[J].实用临床医药杂志,2017,21(7):85-88.
[12]王根在,李恒涛,查建忠,等.500例哮喘患儿主要过敏原分析及干预效果[J].热带医学杂志,2017,17(3):388-391.
[13]王燕,王伟,周静,等.食物不耐受与全身各系统相关性疾病关系研究进展[J].齐鲁医学杂志,2014,29(4):367-370.
[14]赵娟,吴秀娟,张德志,等.新疆地区965例过敏性疾病患者食物特异性IgG抗体检测分析[J].中国中西医结合皮肤性病学杂志,2018,17(2):133-136.
[15]Wilson K,Hill RJ.The role of food intolerance in functional gastrointestinal disorders in children[J].Aust Fam Physician,2014,43(10):686-689.
[16]Ortolani C,Pastorello EA.Food allergies and food intolerances[J].Best Pract Res Clin Gastroenterol,2006,20(3):467-483.
[17]刘春景,杨丽君,王思.湿疹患儿血清总IgE与特异性IgE检测及其相关性[J].中国临床研究,2017,30(12):1631-1633.