壳聚糖及其应用研究进展
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摘要
本文为壳聚糖在各方面的研究应用提供了基础知识及理论依据。综述了壳聚糖的结构、性质、提取方法及壳聚糖在医学领域、水处理方面和作为膜材料在果蔬、肉制品等方面的应用。同时对壳聚糖的应用前景进行了展望。结果壳聚糖独特的理化性质和生物特性使其作为优良的药物制剂辅料,在药物制剂中起着不可估量的作用。另外,壳聚糖良好的成膜性、黏性、抗菌性及成膜后适宜的阻隔性使其在果蔬、肉制品等保鲜领域的应用更为突出。结论壳聚糖是大多数研究应用领域中不可或缺的原材料。
To provide basic knowledge and theoretical basis for the research and application of chitosan in various fields. The structure,properties,extraction methods and applications of chitosan in medicine,water treatment and as membrane materials in fruits,vegetables and meat products were reviewed. At the same time,the application prospect of chitosan is prospected. The unique physicochemical and biological properties of chitosan make it an excellent auxiliary material for drug preparation,and play an immeasurable role in the drug preparation.In addition,chitosan has good film forming,viscosity,antimicrobial property and suitable barrier after film formation that make it more prominent in fruits,vegetables,meat products and other areas of fresh-keeping applications.Chitosan is an indispensable raw material in most fields of research and application.
To provide basic knowledge and theoretical basis for the research and application of chitosan in various fields. The structure,properties,extraction methods and applications of chitosan in medicine,water treatment and as membrane materials in fruits,vegetables and meat products were reviewed. At the same time,the application prospect of chitosan is prospected. The unique physicochemical and biological properties of chitosan make it an excellent auxiliary material for drug preparation,and play an immeasurable role in the drug preparation.In addition,chitosan has good film forming,viscosity,antimicrobial property and suitable barrier after film formation that make it more prominent in fruits,vegetables,meat products and other areas of fresh-keeping applications.Chitosan is an indispensable raw material in most fields of research and application.
引文
[1]杜维维.浅谈壳聚糖及壳聚糖膜[J].塑料包装,2013,23(2):25-28.
[2]张毅,唐春红.壳聚糖膜材料的研究进展[J].化工管理,2016,(33):40.
[3]徐敏,盛玲,季俊峰,等.蒙脱石对赖氨酸和壳聚糖的吸附实验研究[J].高校地质学报,2014,20(4):537-548.
[4]Hiltunen L H,Kelloniemi J P T. Repeated applications of a nonpathogenic streptomyces strain enhance development of suppressiveness to potato common scab[J]. Plant Disease,2017,101(1):224-232.
[5]Peter A Norowski Jr,Tomoko Fujiwara,William C Clem,et al. Novel naturally crosslinked electrospun nanofibrous chitosan mats for guided bone regeneration membranes:material characterization and cytocompatibility[J]. Journal of Tissue Engineering and Regenerative Medicine Research,2015,9(5):577-583.
[6]Li Tingting,Liu Yunguo,Wang Shufan,et al. Synthesis and adsorption application of amine shield-introduced-released porous chitosan hydrogel beads for removal of acid orange 7 from aqueous solutions[J]. Royal Society of Chemistry Advances,2015,5(77):62778-62787.
[7]顾张慧,刘姝,胡晟源,等.一株产几丁质脱乙酰酶海洋细菌的筛选、鉴定及发酵优化[J].食品工业科技,2017,38(18):129-134.
[8]郭昌盛,林海涛,蒋芳.壳聚糖的性能及应用[J].成都纺织高等专科学校学报,2017,34(2):212-215.
[9]Kawasaki T,Nakaji-Hirabayashi T,Masuyama K,et al.Complex film of chitosan and carboxymenthyl cellulose nanofibers[J].Colloids and Surfaces B:Biointerfaces,2016(139):95-99.
[10]Park K. Controlled drug delivery systems:past forward and future back[J].Journal of Controlled Release,2014,190:3-8.
[11]Wicki A,Witzigmann D,Balasubramanian V,et al.Nanomedicine in cancer therapy:challenges,opportunities,and clinical applications[J].Journal of Controlled Release,2015,200:138-157.
[12]Wang Y,Xu H,Wang J,et al. Development of a thermally responsive nanogel based on chitosan-poly(N-isopropylacrylamide-co-acrylamide)for paclitaxel delivery[J]. Journal of Pharmaceutical Sciences,2014,103(7):2012-2021.
[13]Zhu QL,Zhou Y,Guan M,et al.Low-density lipoproteincoupled N-succinyl chitosan nanoparticles co-delivering si RNA and doxorubicin for hepatocyte-targeted therapy[J].Biomaterials,2014,35(22):5965-5976.
[14]李彦艳,张闪闪,任国栋.甲壳动物、昆虫、真菌中甲壳素的提取进展[J].食品研究与开发,2015,36(7):122-126.
[15]S.V.Nemtsev,O.Yu.Zueva,M.R.Khismatullin,et al.Isolation of chitin and chitosan from honeybees[J]. Applied Biochemistry and Microbiology,2004,40(1):39-43.
[16]杨磊,李鑫,余世袁,等.米根霉废菌体制备壳聚糖及其成膜性能[J].林产化学与工业,2015,35(4):35-40.
[17]Abdel-Cawad K M,Hifney A F,Fawzy M A,et al.Technology optimizati on of chitosan production from Aspergillus niger,biomass and its functional activities[J]. Food Hydrocolloids,2017,63:593-601.
[18]江丹丹,王松华,王敏,等.黑豆粉对灵芝壳聚糖产量影响的研究[J].安徽科技学院学报,2017,31(5):36-40.
[19]Lee JS,Baek SD,V enkatesan J,et al. In vivo study of chitosan-natural nano hydroxyapatite scaffolds for bone tissue regeneration[J]. International Journal of Biological Macromolecules,2014,67:360-366.
[20]Riccardo A.A.Muzzarelli,Mohamad EI Mehtedi,Carlo Bottegoni,et al. Genipin-crosslinked chitosan gels and scaffolds for tissue engineering and regeneration of cartilage and bone[J].Marinedrugs,2015(13):7314-7338.
[21]Charito TA,Bin J,Barba JR,et al. Hemosyatic efficacy evaluation of radiation crosslinked carboxymethyl kappacarrageenan and chitosan with varying degrees of substitution[J].Radiation Physics and Chemistry,2016,124:124-129.
[22]Kuroyanagi Y. Tissue-engineered products for skin regenerative medicine[J]. Open Journal of Regenerative Medicine,2016,5(3):61.
[23]孟卉,袁嫣昊.壳聚糖处理污水中的Pb2+优化条件研究[J].山东化工,2017,46(2):132-133.
[24]Panaitescu D M,Frone A N,Ghiurea M,et al.Influence of storage conditions on starch/PVA films containing cellulose nanofibers[J].Industrial Crops and Products,2015,70:170-177.
[25]金芝苹,王爽,闫旭,等.可食性壳聚糖涂膜在食品保鲜中的应用[J].吉林医药学院学报,2018,39(1):42-44.
[26]Jayakumar R,Menon D,Manzoor K,et al Biomedical applications of chitin and chitosan based nanomaterials-A short review[J].Carbohydrate Polymers,2010,82(2):227-232.
[27]刘伟.姜酚抑菌作用及姜酚-壳聚糖复合膜性质与应用研究[D].北京:中国农业大学,2015.
[28]马豫峰,蔡继业,杨培慧,等.壳聚糖自组装复合修饰血红蛋白的研究[J].高分子材料科学与工程,2005,21(1):272-275.
[29]聂柳慧.用壳聚糖膜作保鲜包装材料的研究[N].中国包装报,2011-2-24(3).
[30]Avid Adeaida,Bierbrauer Karina,Pucci Graciela,et al.Study of optimization of the synthesis and properties of biocomposite films based on grafted chitosan[J]. Journal of Food Engineering,2012,109(4):109,752-761.
[31]Jawad A H,Azharul M,Hameed B H.Cross-linked chitosan thin film coated onto glass plate as an effective adsorbent for adsorption of reactive orange 16[J]. International Journal of Biological Macromolecules,2017,95:743-749.
[32]Liu J,Liu S,Wu Q,et al. Effect of protocatechuic acid incorporation on the physical, mechanical, structural and antioxidant properties of chitosan film[J]. Food Hydrocolloids,2017,73:90-100.
[33]Rupei T,Yumin D,Lihong F.Dialdehyde starch-crosslinked chitosan films and their antimicrobial effects[J].Polymer Science Part B:Polymer Physics,2003,41(9):993-997.
[34]Wasina Thakhiew, Sakamon Devahastin, Somchart Soponronnarit. Effects of drying methods and plasticizer concentration on some physical and mechanical properties of edible chitosan films[J]. Journal of Food Engineering,2010,99(2):216.
[35]谭春园,解保生,丁仲鹃.不同分子量壳聚糖膜的制备研究[J].昆明医学院学报,2011(8):9-12,42.
[36]周娓娓,于春玲,金美花,等.壳聚糖膜的制备及其表面浸润性[J].大连工业大学学报,2012(4):262-264.
[37]AB de A,AF B,LC Santana. Impact of edible chitosancassava starch coatings enriched with Lippia gr-acilis Schauer genotype mixtures on the shelf life of guavas(Psidium guajava L.)during storage at room te-mperature[J]. Food Chem,2015,171:108-116.
[38]Youssef AM,Abouyousef H,Elsayed SM,et al. Mechanical and antibacterial properties of novel high performance chitosan/nanocomposite films[J]. International Journal of Biological Macromolecules,2015,76:25-32.
[39]董峰.基于果蔬包装的纳米纤维素/壳聚糖复合膜的制备、性能及应用[D].哈尔滨:东北林业大学,2015.
[40]金芝苹,王爽,闫旭,等.可食性壳聚糖涂膜在食品保鲜中的应用[J].吉林医药学院学报,2018,39(1):42-44.
[41]郭玉霞.多糖壳聚糖保鲜作用的研究与应用[J].现代食品,2016(11):12-13.
[42]吴春华.壳聚糖衍生物分子修饰机理及其在银鲳鱼保鲜中的应用研究[D].杭州:浙江大学,2017.
[43]袁蒙蒙,高丽朴,王清,等.壳聚糖涂膜对西葫芦保鲜效果的研究[J].食品研究与开发,2013,34(6):101-104.
[44]王秀娟,张坤生,任云霞.添加剂对壳聚糖涂膜保鲜虾的效果研究[J].食品科技,2008(7):239-242.
[45]Satnam S,Ron B,Sibel R. Chitosan inhibits growth of spoilage micro-organisms in chilled pork products[J]. Food Microbiology,2002,19(2):175-182.
[2]张毅,唐春红.壳聚糖膜材料的研究进展[J].化工管理,2016,(33):40.
[3]徐敏,盛玲,季俊峰,等.蒙脱石对赖氨酸和壳聚糖的吸附实验研究[J].高校地质学报,2014,20(4):537-548.
[4]Hiltunen L H,Kelloniemi J P T. Repeated applications of a nonpathogenic streptomyces strain enhance development of suppressiveness to potato common scab[J]. Plant Disease,2017,101(1):224-232.
[5]Peter A Norowski Jr,Tomoko Fujiwara,William C Clem,et al. Novel naturally crosslinked electrospun nanofibrous chitosan mats for guided bone regeneration membranes:material characterization and cytocompatibility[J]. Journal of Tissue Engineering and Regenerative Medicine Research,2015,9(5):577-583.
[6]Li Tingting,Liu Yunguo,Wang Shufan,et al. Synthesis and adsorption application of amine shield-introduced-released porous chitosan hydrogel beads for removal of acid orange 7 from aqueous solutions[J]. Royal Society of Chemistry Advances,2015,5(77):62778-62787.
[7]顾张慧,刘姝,胡晟源,等.一株产几丁质脱乙酰酶海洋细菌的筛选、鉴定及发酵优化[J].食品工业科技,2017,38(18):129-134.
[8]郭昌盛,林海涛,蒋芳.壳聚糖的性能及应用[J].成都纺织高等专科学校学报,2017,34(2):212-215.
[9]Kawasaki T,Nakaji-Hirabayashi T,Masuyama K,et al.Complex film of chitosan and carboxymenthyl cellulose nanofibers[J].Colloids and Surfaces B:Biointerfaces,2016(139):95-99.
[10]Park K. Controlled drug delivery systems:past forward and future back[J].Journal of Controlled Release,2014,190:3-8.
[11]Wicki A,Witzigmann D,Balasubramanian V,et al.Nanomedicine in cancer therapy:challenges,opportunities,and clinical applications[J].Journal of Controlled Release,2015,200:138-157.
[12]Wang Y,Xu H,Wang J,et al. Development of a thermally responsive nanogel based on chitosan-poly(N-isopropylacrylamide-co-acrylamide)for paclitaxel delivery[J]. Journal of Pharmaceutical Sciences,2014,103(7):2012-2021.
[13]Zhu QL,Zhou Y,Guan M,et al.Low-density lipoproteincoupled N-succinyl chitosan nanoparticles co-delivering si RNA and doxorubicin for hepatocyte-targeted therapy[J].Biomaterials,2014,35(22):5965-5976.
[14]李彦艳,张闪闪,任国栋.甲壳动物、昆虫、真菌中甲壳素的提取进展[J].食品研究与开发,2015,36(7):122-126.
[15]S.V.Nemtsev,O.Yu.Zueva,M.R.Khismatullin,et al.Isolation of chitin and chitosan from honeybees[J]. Applied Biochemistry and Microbiology,2004,40(1):39-43.
[16]杨磊,李鑫,余世袁,等.米根霉废菌体制备壳聚糖及其成膜性能[J].林产化学与工业,2015,35(4):35-40.
[17]Abdel-Cawad K M,Hifney A F,Fawzy M A,et al.Technology optimizati on of chitosan production from Aspergillus niger,biomass and its functional activities[J]. Food Hydrocolloids,2017,63:593-601.
[18]江丹丹,王松华,王敏,等.黑豆粉对灵芝壳聚糖产量影响的研究[J].安徽科技学院学报,2017,31(5):36-40.
[19]Lee JS,Baek SD,V enkatesan J,et al. In vivo study of chitosan-natural nano hydroxyapatite scaffolds for bone tissue regeneration[J]. International Journal of Biological Macromolecules,2014,67:360-366.
[20]Riccardo A.A.Muzzarelli,Mohamad EI Mehtedi,Carlo Bottegoni,et al. Genipin-crosslinked chitosan gels and scaffolds for tissue engineering and regeneration of cartilage and bone[J].Marinedrugs,2015(13):7314-7338.
[21]Charito TA,Bin J,Barba JR,et al. Hemosyatic efficacy evaluation of radiation crosslinked carboxymethyl kappacarrageenan and chitosan with varying degrees of substitution[J].Radiation Physics and Chemistry,2016,124:124-129.
[22]Kuroyanagi Y. Tissue-engineered products for skin regenerative medicine[J]. Open Journal of Regenerative Medicine,2016,5(3):61.
[23]孟卉,袁嫣昊.壳聚糖处理污水中的Pb2+优化条件研究[J].山东化工,2017,46(2):132-133.
[24]Panaitescu D M,Frone A N,Ghiurea M,et al.Influence of storage conditions on starch/PVA films containing cellulose nanofibers[J].Industrial Crops and Products,2015,70:170-177.
[25]金芝苹,王爽,闫旭,等.可食性壳聚糖涂膜在食品保鲜中的应用[J].吉林医药学院学报,2018,39(1):42-44.
[26]Jayakumar R,Menon D,Manzoor K,et al Biomedical applications of chitin and chitosan based nanomaterials-A short review[J].Carbohydrate Polymers,2010,82(2):227-232.
[27]刘伟.姜酚抑菌作用及姜酚-壳聚糖复合膜性质与应用研究[D].北京:中国农业大学,2015.
[28]马豫峰,蔡继业,杨培慧,等.壳聚糖自组装复合修饰血红蛋白的研究[J].高分子材料科学与工程,2005,21(1):272-275.
[29]聂柳慧.用壳聚糖膜作保鲜包装材料的研究[N].中国包装报,2011-2-24(3).
[30]Avid Adeaida,Bierbrauer Karina,Pucci Graciela,et al.Study of optimization of the synthesis and properties of biocomposite films based on grafted chitosan[J]. Journal of Food Engineering,2012,109(4):109,752-761.
[31]Jawad A H,Azharul M,Hameed B H.Cross-linked chitosan thin film coated onto glass plate as an effective adsorbent for adsorption of reactive orange 16[J]. International Journal of Biological Macromolecules,2017,95:743-749.
[32]Liu J,Liu S,Wu Q,et al. Effect of protocatechuic acid incorporation on the physical, mechanical, structural and antioxidant properties of chitosan film[J]. Food Hydrocolloids,2017,73:90-100.
[33]Rupei T,Yumin D,Lihong F.Dialdehyde starch-crosslinked chitosan films and their antimicrobial effects[J].Polymer Science Part B:Polymer Physics,2003,41(9):993-997.
[34]Wasina Thakhiew, Sakamon Devahastin, Somchart Soponronnarit. Effects of drying methods and plasticizer concentration on some physical and mechanical properties of edible chitosan films[J]. Journal of Food Engineering,2010,99(2):216.
[35]谭春园,解保生,丁仲鹃.不同分子量壳聚糖膜的制备研究[J].昆明医学院学报,2011(8):9-12,42.
[36]周娓娓,于春玲,金美花,等.壳聚糖膜的制备及其表面浸润性[J].大连工业大学学报,2012(4):262-264.
[37]AB de A,AF B,LC Santana. Impact of edible chitosancassava starch coatings enriched with Lippia gr-acilis Schauer genotype mixtures on the shelf life of guavas(Psidium guajava L.)during storage at room te-mperature[J]. Food Chem,2015,171:108-116.
[38]Youssef AM,Abouyousef H,Elsayed SM,et al. Mechanical and antibacterial properties of novel high performance chitosan/nanocomposite films[J]. International Journal of Biological Macromolecules,2015,76:25-32.
[39]董峰.基于果蔬包装的纳米纤维素/壳聚糖复合膜的制备、性能及应用[D].哈尔滨:东北林业大学,2015.
[40]金芝苹,王爽,闫旭,等.可食性壳聚糖涂膜在食品保鲜中的应用[J].吉林医药学院学报,2018,39(1):42-44.
[41]郭玉霞.多糖壳聚糖保鲜作用的研究与应用[J].现代食品,2016(11):12-13.
[42]吴春华.壳聚糖衍生物分子修饰机理及其在银鲳鱼保鲜中的应用研究[D].杭州:浙江大学,2017.
[43]袁蒙蒙,高丽朴,王清,等.壳聚糖涂膜对西葫芦保鲜效果的研究[J].食品研究与开发,2013,34(6):101-104.
[44]王秀娟,张坤生,任云霞.添加剂对壳聚糖涂膜保鲜虾的效果研究[J].食品科技,2008(7):239-242.
[45]Satnam S,Ron B,Sibel R. Chitosan inhibits growth of spoilage micro-organisms in chilled pork products[J]. Food Microbiology,2002,19(2):175-182.