产后子宫内膜炎与围生期解脲脲原体感染有关
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摘要
为了探讨围生期支原体感染与产后子宫内膜炎的关系及治疗,本研究选取产后子宫内膜炎患者73例作为观察组,同时选取正常产妇80例作为对照组。通过检测两组解脲脲原体(Uu)和人型支原体(Mh)感染情况,同时给予观察组常规治疗,本研究发现观察组Uu阳性比例为32.88%,明显高于对照组(p<0.05);观察组和对照组Mh阳性差异比较无统计学意义(p>0.05);观察组Uu阳性和Mh阳性产妇发生早产或胎膜早破的比例分别为62.50%和25.00%,明显高于支原体感染阴性产妇(p<0.05);观察组Uu阳性、Mh阳性和阴性患者治疗效果比较差异无统计学意义(p>0.05);观察组治疗后Uu阳性率为10.96%,明显较治疗前降低(p<0.05);观察组治疗前后Mh阳性率比较差异不显著(p>0.05)。本研究表明,Uu感染与产后子宫内膜炎发生有一定关系,围生期应加强Uu感染筛查,并及时进行治疗。
To investigate the relationship of perinatal mycoplasma infection and postpartum endometritis and treatment, 73 cases of postpartum endometritis were selected as the observation group and 80 cases of normal parturients were selected as the control group. By detecting the Ureaplasma urealyticum(Uu) and Mycoplasma human(Mh) infection of two groups, and giving routine treatment to the observation group, it was found that the positive ratio of Uu in the observation group was 32.88%, which was significantly higher than that in the control group(p<0.05), and there was no significant difference in Mh positive between the observation group and the control group(p>0.05); the proportion of Uu positive and Mh positive pregnant women who had preterm labor or premature rupture of membranes were 62.50% and 25%, which were significantly higher than those with negative mycoplasma infection(p<0.05); There was no significant difference in the treatment effect of Uu positive, Mh positive and negative patients in the observation group(p>0.05); the positive rate of Uu in the observation group after treatment was 10.96%, which was significantly lower than that before treatment(p<0.05); there was no significant difference in the positive rate of Mh before and after treatment in the observation group(p>0.05). Our research indicated thatthere was a certain relationship between Uu infection and postpartum endometritis. Screening for Uu infection should be strengthened in perinatal period, and treatment should be carried out in time.
To investigate the relationship of perinatal mycoplasma infection and postpartum endometritis and treatment, 73 cases of postpartum endometritis were selected as the observation group and 80 cases of normal parturients were selected as the control group. By detecting the Ureaplasma urealyticum(Uu) and Mycoplasma human(Mh) infection of two groups, and giving routine treatment to the observation group, it was found that the positive ratio of Uu in the observation group was 32.88%, which was significantly higher than that in the control group(p<0.05), and there was no significant difference in Mh positive between the observation group and the control group(p>0.05); the proportion of Uu positive and Mh positive pregnant women who had preterm labor or premature rupture of membranes were 62.50% and 25%, which were significantly higher than those with negative mycoplasma infection(p<0.05); There was no significant difference in the treatment effect of Uu positive, Mh positive and negative patients in the observation group(p>0.05); the positive rate of Uu in the observation group after treatment was 10.96%, which was significantly lower than that before treatment(p<0.05); there was no significant difference in the positive rate of Mh before and after treatment in the observation group(p>0.05). Our research indicated thatthere was a certain relationship between Uu infection and postpartum endometritis. Screening for Uu infection should be strengthened in perinatal period, and treatment should be carried out in time.
引文
Allen S.R., 1998, Tocolytic therapy in preterm, PROM, 4(4):842-848
Chaim W.,Horowitz S.,David J.B.,Ingel F.,Evinson B.,and Mazor M.,2003,Ureaplasma urealyticum in the development of postpartum endometritis,Eur.J.Obstet.Gynecol.Reprod.Biol.,109(2):145-148
Diala F.,Mercer F.,and Johnson P.J.,2015,Mycoplasma hominis infection status of trichomonas vaginalis affects cytokine secretion from primary human monocytes,J.Investig.Med.,63(1):171-172
Jacobsson B.,Pernevi P.,Chidekel L.,and J觟rgen Platz-Christensen J.,2015,Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis,Acta.Obstet.Gynecol.Scand.,81(11):1006-1010
Jia S.R.,Hu M.,Jiang L.H.,Zhu J.M.,Zhao S.Q.,and Chen Z.Y.,2017,Detection and susceptibility test of suspected 4 414cases of urogenital tract mycoplasma infection in Chongqing,Chongqing Yixue(Chongqing Medicine),46(5):609-611(贾双荣,胡萌,蒋琳华,朱金梅,赵世巧,陈忠余,2017,重庆地区4 414例泌尿生殖道支原体检测及药敏分析,重庆医学,46(5):609-611)
Jin H.P.,Bian B.H.,Cao H.H.,Yang H.Y.,and Zou Z.Y.,2016,Correlation between mycoplasma infection and postpartum endometritis in perinatal period and the nursing care,Zhongguo Weishengtaixue Zazhi(Chinese Journal of Microecology),28(1):105-107(金海萍,边保华,曹海华,杨慧雅,邹珍友,2016,围生期孕妇支原体感染与产后子宫内膜炎的相关性分析及护理对策,中国微生态学杂志,28(1):105-107)
Li M.H.,Wang F.,Lv W.F.,and Li C.X.,2016,Investigation of mycoplasma infection in urogenital tract of pregnancy women in some domestic area,Zhongguo Xiaoduxue Zazhi(Chinese Journal of Disinfection),33(4):343-345(李美红,王峰,吕婉飞,李春仙,2016,国内某地区妊娠妇女生殖道支原体感染现状调查,中国消毒学杂志,33(4):343-345)
Ma X.P.,and Gao X.Q.,2017,The effect of Ureaplasma urealyticum on the level of P34H expression,the activity of hyaluronidase,and DNA fragmentation in human spermatozoa,Am.J.Reprod.Immunol.,77(1):e12600
Mao C.Y.,and Zheng W.A.,2017,Analysis on bacterial vaginosis and mycoplasma infection status in female patients with infertility,Chongqing Yixue(Chongqing Medicine),46(31):4373-4374(毛春燕,郑文爱,2017,女性不孕症患者细菌性阴道病与支原体感染状况分析,重庆医学,46(31):4373-4374)
Song D.M.,and Huang X.W.,2017,Hysteroscopic diagnosis of chronic endometritis,Guoji Shengzhijiankang/Jihuashengyu Zazhi(Journal of International Reproductive Health/Family Planning),36(3):234-237(宋冬梅,黄晓武,2017,慢性子宫内膜炎的宫腔镜诊断,国际生殖健康/计划生育杂志,36(3):234-237)
Wang L.,Xu R.,Zhang S.H.,Ma S.Y.,and Xue Y.N.,2016,Meta-analysis on efficacy of Fuke Qianjin tablets(capsules)combined with antibiotics in treatment of endometritis,Zhongguo Zhongyao Zazhi(China Journal of Chinese Materia Medica),41(16):3090-3095(王莉,徐锐,张少华,马淑云,薛亚南,2016,妇科千金片(胶囊)联合抗生素治疗子宫内膜炎疗效的Meta分析,中国中药杂志,41(16):3090-3095)
Xie J.R.,Zhang L.,and Hu Y.,2017,Effect of vaginal disinfection with drugs on endometritis and surgical site infection in puerpera undergoing cesarean section,Zhonghua Yiyuan Ganranxue Zazhi(Chinese Journal of Nosocomiology),27(11):2595-2598(谢吉蓉,张玲,胡燕,2017,应用药物阴道消毒对剖宫产妇女子宫内膜炎和手术部位感染的影响,中华医院感染学杂志,27(11):2595-2598)
Zhu S.H.,Li L.,Zhu M.L.,Fu L.,and Jiang E.X.,2016,Influence of azithromycin combined with woman's health agent on uterine hemodynamics of patients with Mycoplasma pelvic inflammatory disease,Zhonghua Yiyuan Ganranxue Zazhi(Chinese Journal of Nosocomiology),26(1):167-168(朱仕华,李玲,朱明莉,付楝,江二喜,2016,阿奇霉素联合妇康健合剂治疗支原体属感染性盆腔炎患者对子宫血流动力学指标的影响研究,中华医院感染学杂志,26(1):167-168)
Chaim W.,Horowitz S.,David J.B.,Ingel F.,Evinson B.,and Mazor M.,2003,Ureaplasma urealyticum in the development of postpartum endometritis,Eur.J.Obstet.Gynecol.Reprod.Biol.,109(2):145-148
Diala F.,Mercer F.,and Johnson P.J.,2015,Mycoplasma hominis infection status of trichomonas vaginalis affects cytokine secretion from primary human monocytes,J.Investig.Med.,63(1):171-172
Jacobsson B.,Pernevi P.,Chidekel L.,and J觟rgen Platz-Christensen J.,2015,Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis,Acta.Obstet.Gynecol.Scand.,81(11):1006-1010
Jia S.R.,Hu M.,Jiang L.H.,Zhu J.M.,Zhao S.Q.,and Chen Z.Y.,2017,Detection and susceptibility test of suspected 4 414cases of urogenital tract mycoplasma infection in Chongqing,Chongqing Yixue(Chongqing Medicine),46(5):609-611(贾双荣,胡萌,蒋琳华,朱金梅,赵世巧,陈忠余,2017,重庆地区4 414例泌尿生殖道支原体检测及药敏分析,重庆医学,46(5):609-611)
Jin H.P.,Bian B.H.,Cao H.H.,Yang H.Y.,and Zou Z.Y.,2016,Correlation between mycoplasma infection and postpartum endometritis in perinatal period and the nursing care,Zhongguo Weishengtaixue Zazhi(Chinese Journal of Microecology),28(1):105-107(金海萍,边保华,曹海华,杨慧雅,邹珍友,2016,围生期孕妇支原体感染与产后子宫内膜炎的相关性分析及护理对策,中国微生态学杂志,28(1):105-107)
Li M.H.,Wang F.,Lv W.F.,and Li C.X.,2016,Investigation of mycoplasma infection in urogenital tract of pregnancy women in some domestic area,Zhongguo Xiaoduxue Zazhi(Chinese Journal of Disinfection),33(4):343-345(李美红,王峰,吕婉飞,李春仙,2016,国内某地区妊娠妇女生殖道支原体感染现状调查,中国消毒学杂志,33(4):343-345)
Ma X.P.,and Gao X.Q.,2017,The effect of Ureaplasma urealyticum on the level of P34H expression,the activity of hyaluronidase,and DNA fragmentation in human spermatozoa,Am.J.Reprod.Immunol.,77(1):e12600
Mao C.Y.,and Zheng W.A.,2017,Analysis on bacterial vaginosis and mycoplasma infection status in female patients with infertility,Chongqing Yixue(Chongqing Medicine),46(31):4373-4374(毛春燕,郑文爱,2017,女性不孕症患者细菌性阴道病与支原体感染状况分析,重庆医学,46(31):4373-4374)
Song D.M.,and Huang X.W.,2017,Hysteroscopic diagnosis of chronic endometritis,Guoji Shengzhijiankang/Jihuashengyu Zazhi(Journal of International Reproductive Health/Family Planning),36(3):234-237(宋冬梅,黄晓武,2017,慢性子宫内膜炎的宫腔镜诊断,国际生殖健康/计划生育杂志,36(3):234-237)
Wang L.,Xu R.,Zhang S.H.,Ma S.Y.,and Xue Y.N.,2016,Meta-analysis on efficacy of Fuke Qianjin tablets(capsules)combined with antibiotics in treatment of endometritis,Zhongguo Zhongyao Zazhi(China Journal of Chinese Materia Medica),41(16):3090-3095(王莉,徐锐,张少华,马淑云,薛亚南,2016,妇科千金片(胶囊)联合抗生素治疗子宫内膜炎疗效的Meta分析,中国中药杂志,41(16):3090-3095)
Xie J.R.,Zhang L.,and Hu Y.,2017,Effect of vaginal disinfection with drugs on endometritis and surgical site infection in puerpera undergoing cesarean section,Zhonghua Yiyuan Ganranxue Zazhi(Chinese Journal of Nosocomiology),27(11):2595-2598(谢吉蓉,张玲,胡燕,2017,应用药物阴道消毒对剖宫产妇女子宫内膜炎和手术部位感染的影响,中华医院感染学杂志,27(11):2595-2598)
Zhu S.H.,Li L.,Zhu M.L.,Fu L.,and Jiang E.X.,2016,Influence of azithromycin combined with woman's health agent on uterine hemodynamics of patients with Mycoplasma pelvic inflammatory disease,Zhonghua Yiyuan Ganranxue Zazhi(Chinese Journal of Nosocomiology),26(1):167-168(朱仕华,李玲,朱明莉,付楝,江二喜,2016,阿奇霉素联合妇康健合剂治疗支原体属感染性盆腔炎患者对子宫血流动力学指标的影响研究,中华医院感染学杂志,26(1):167-168)