摘要
目的:总结体外膜肺氧合(ECMO)与主动脉球囊反搏(IABP)联合辅助在心血管外科术后心原性休克(PCS)患者中的救治经验,分析影响疗效的因素。方法:回顾分析2006年2月至2017年3月阜外医院60例因PCS而接受ECMO与IABP联合辅助循环的患者临床资料。对比生存出院(成功脱机并存活出院)患者与非生存出院(撤机后院内死亡或未成功脱机)患者的临床特征,Logistic回归分析生存出院的独立预测因子。结果:38例(63.3%)患者于术中安装ECMO,22例(36.7%)患者于术后安装ECMO。38例(63.3%)患者ECMO与IABP同时安装。接受联合辅助患者的主要手术类型为心脏移植术23例(38.3%)和冠状动脉旁路移植术26例(43.3%)。ECMO成功脱机29例(48.3%),生存出院26例(43.3%)。生存出院患者的床边安装ECMO比例较非生存出院患者低(11.5%vs 41.2%, P=0.012),同期安装ECMO比例较非生存出院患者高(80.8%vs 50.0%, P=0.014)。Logistic回归分析显示,IABP同期安装ECMO是生存出院的独立预测因子(OR=0.177, 95%CI:0.044~0.718, P=0.015)。生存出院患者出现肾功能衰竭并发症比例(15.4%vs 58.8%, P=0.001)和多器官功能衰竭并发症比例(0%vs 29.4%, P=0.003)均较非生存出院患者低。生存出院患者远期随访发现,心脏移植术患者比其他手术患者有更好的远期生存率(P=0.0358)。结论:对于PCS患者,ECMO与IABP联合辅助是一种有效的短期生命支持治疗方法。同时安装IABP与ECMO进行循环辅助可能获得更好的短期临床结果。
Objectives: The aim of this study is to report the experience of combined application of extracorporeal membrane oxygenation(ECMO) with intra-aortic balloon pumping(IABP) in patients with postcardiotomy cardiac shock(PCS) in Fuwai hospital.Methods: A total of 60 consecutive patients who received both ECMO and IABP(concomitantly ≥ 24 hours) for PCS between February 2006 to March 2017 in Fuwai Hospital were included in this study. Clinical characteristics of the patients were collected retrospectively and compared between survivors and non-survivors. Logistic regression analysis was used for predictors for survival of discharge.Results: The mean age of patients was(51.4±12.7) years and 75.0% patients were males. ECMO was implanted intraoperatively in 38(63.3%) patients and post-operatively in 22(36.7%) patients. ECMO was implanted concurrently with IABP in38(63.3%) patients. Heart transplantation(38.3%) and coronary artery bypass graft(43.3%) were the main surgical procedures. ECMO was weaned successfully in 48.3% patients, and the rate of survival to discharge was 43.3%. Survivors received less bedside ECMO implantation(11.5% vs 41.2%, P=0.012) and more concurrent implantation of ECMO with IABP(80.8% vs 50.0%, P=0.014). Concurrent implantation of IABP with ECMO(OR=0.177, 95% CI: 0.044~0.718, P=0.015) was an independent predictor for survival to discharge. As for complications, the rate of renal failure(58.8% vs 15.4%, P=0.001) and multiple organ dysfunction syndrome(29.4% vs 0%, P=0.003) were significantly higher in non-survivors during hospitalization. Patients who had heart transplantation had a better long-term survival than patients with other surgeries(P=0.0358).Conclusions: ECMO combined with IABP, as a short-term mechanical life support, is an effective therapy option for patients with PCS. Concurrent implantation of ECMO with IABP provides better short-term outcome for patients with PCS.
引文
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