抗菌肽分离纯化分析研究进展
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摘要
抗菌肽与抗生素等传统灭菌剂的作用相似,多数具有强碱性、热稳定性以及广谱抗菌等特点,特别是某些抗菌肽对部分真菌、原虫、病毒及癌细胞等均具有强有力的杀伤作用。抗菌肽的分离纯化分析对于抗菌肽的应用具有重要意义,本文重点对其研究进展进行概述。
Similar to the traditional antibiotics, most antibacterial peptides possess strong basicity, thermal stability and broad spectrum antibacterial. What's more, some antibacterial peptides show strong effect on sterilizing epiphyte, protozoon, virus and cancer cell. In this review, we aim to study the progress on the purification, separation and analysis of antibacterial peptides due to the great significance of it.
Similar to the traditional antibiotics, most antibacterial peptides possess strong basicity, thermal stability and broad spectrum antibacterial. What's more, some antibacterial peptides show strong effect on sterilizing epiphyte, protozoon, virus and cancer cell. In this review, we aim to study the progress on the purification, separation and analysis of antibacterial peptides due to the great significance of it.
引文
[1]杨乐乐,陈阳城,刘锦杰.昆虫蛋白对动物免疫功能的影响[J].广东饲料,2017,26(02):28-30.
[2]王大勇.综述抗菌肽在制药工程中的应用机理及发展[J].科技与企业,2013,4:287.
[3]Gaspar D,Veiga AS,Castanho MARB.From antimicrobial to anticancer peptides a review[J].Front Microbiol,2013,4:294.
[4]郭斌,谢宁,白珊珊,等.抗菌肽MUC7联合双歧杆菌体外抗真菌研究[J].重庆医学,2015,44(03):309-311.
[5]Torrent M,Pulido D,Rivas L,et al.Antimicrobial peptide action on parasites[J].Curr Drug Targets,2012,13(9):1138-1147.
[6]代玉华,霍红杰,王怀位,等.抗菌肽抗疟原虫作用的研究进展[J].中国寄生虫学与寄生虫病杂志,2010,28(06):455-458.
[7]Hsieh IN,Hartshorn KL.The role of antimicrobial peptides in influenza virus infection and their potential as antiviral and immunomodulatory therapy[J].Pharmaceuticals,2016,9:53.
[8]赵洁,孙燕,李晶,等.动物抗菌肽的抗病毒活性[J].医学分子生物学杂志,2008,5:466-469.
[9]Chu HL,Yip BS,Chen KH,et al.Novel antimicrobial peptides with high anticancer activity and selectivity[J].Plo S One,2015,10(5):e0126390.
[10]许洪杰,张云杰.抗菌肽在水产养殖中的应用前景[J].科学养鱼,2016,6:87.
[11]关静姝,李波.综述抗菌肽的生物学功能[J].饲料与畜牧,2013,9:60-61.
[12]Gordon YJ,Romanowski EG.A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs[J].Curr Eye Res,2015,30(7):505-515.
[13]Marr AK,Gooderham WJ,Hancock REW.Antibacterial peptides for therapeutic use:obstacles and realistic outlook[J].Curr Opin Pharmacol,2006,6:468-472.
[14]Rai M,Pandit R,Gaikwad S,et al.Antimicrobial peptides as natural bio-preservative to enhance the shelf-life of food[J].J Food Sci Technol,2016,53:3381-3394.
[15]郭晓敏.抗菌肽的融合表达及其生物活性的初步研究[D].浙江理工大学,2012.
[16]苗建银,柯畅,郭浩贤,等.抗菌肽的提取分离及抑菌机理研究进展[J].现代食品科技,2014,30(01):233-240.
[17]陈飞龙.Lactobacillus paracasei FX-6产抗菌肽对金黄色葡萄球菌作用机制及其应用研究[D].华南农业大学,2016.
[18]宋贤丽.茳芒决明抗菌蛋白的分离纯化及当归和六种决明属植物的毛细管电泳指纹图谱[D].四川大学,2003.
[19]张先文,张伟,赵小凡,等.家蝇天然抗菌肽的分离纯化与活性分析[J].生物技术,2007,(02):51-54.
[20]江惠.竹叶天然抗菌肽的分离纯化、抑菌活性与抑菌机理研究[D].西华大学,2011.
[21]齐珂珂,康相涛,韩瑞丽,等.鸵鸟异嗜白细胞抗菌肽的分离、纯化及部分性质分析[J].农业生物技术学报,2009,17(03):455-461.
[22]胡建和,杭柏林,王青,等.牛红细胞源抗菌肽的分离纯化与活性鉴定[J].西北农林科技大学学报(自然科学版),2010,38(02):36-40.
[23]胡建和.牛血液红细胞中抗菌肽的纯化及抗菌活性的初步鉴定[A].中国畜牧兽医学会,2009:4.
[24]王延卓.猪血中抗菌肽的提取及体外抗菌活性研究[D].吉林农业大学,2007.
[25]樊陈,高兆建,张桂英,等.地衣芽孢杆菌抗菌肽的纯化及抗菌特性分析[J].中国农学通报,2013,29(33):313-318.
[26]潘顺,刘雷,付贤树,等.高效液相色谱-质谱联用法高通量筛选及检测哈茨木霉菌发酵液中pep-taibols类抗菌肽[J].中国药学杂志,2012,47(22):1849-1855.
[27]Huang YB,Pan Li,Zhao LJ,et al.Structure guided RPHPLC chromatography of diastereomericα-helical peptide analogs substituted with single amino acid stereoisomers[J].Biomed Chromatogr,2015,28:511-517.
[28]Song R,WeiRB,LuoHY,et al.Isolation and characterization of an antibacterial peptide fraction from the pepsin hydrolysate of Half-Fin anchovy[J].Molecules,2012,17:2980-2991.
[29]Wong JH,Dcw Ip,Ng TB,et al.A defensin-like peptide from Phaseolus vulgaris cv.‘King Pole Bean’[J].Food Chem,2012,135:408-414.
[30]Capriotti AL,Cavaliere C,Piovesana S,et al.Recent trends in the analysis of bioactive peptides in milk and dairy products[J].Anal Bioanal Chem,2016,408:2677-2685.
[31]Kelly GJ,Kia AFA,Hassan F,et al.Polymeric prodrug combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells[J].Org Biomol Chem,2016,14:9278.
[32]Belal JM,Zaiton H,Fatimah ABr,et al.Identification of antifungal peptides produced by Lactobacillus plantarum IS10 grown in the MRS broth[J].Food Control,2016,59:27-30.
[33]Buszewski B,Noga S.Hydrophilic interaction liquid chromatography(HILIC)-apowerful separation technique[J].Anal Bioanal Chem,2012,402:231-247.
[34]Colin TM,Robert SH.Mixed-mode hydrophilic interaction/cation-exchange chromatography(HILIC/CEX)of peptides and proteins[J].J Sep Sci,2008,31:2754-2773.
[35]Surugau LN.Peptide separation by capillary electrophoresis with ultraviolet detection:some simple approaches to enhance detection sensitivity and resolution[J].Zeolites,2011,15(4):245-250.
[36]Tang WT,Pu CF,Man Li,et al.Interaction between antibacterial peptide apep10 and escherichia coli membrane lipids evaluated using liposome as pseudo Stationary phase[J].Plo S One,12:e0164594.
[37]Zhu ZF,Lu JJ,Liu SR.Protein separation by capillary gel electrophoresis:a review[J].Anal Chim Acta,2012,709:21-31.
[38]Guillo C,Barlow D,Perrett D,et al.Micellar electrokinetic capillary chromatography and data alignment analysis:a new tool in urine profiling[J].J Chromatogr A,2004,1027:203-212.
[39]RighettiR G,Sebastiano R,Citterio A.Capillary electrophoresis and isoelectric focusing in peptide and protein analysis[J].Proteomics,2013,13:325.
[40]Zhang RW,Liu WT,Geng LL,et al.Quantitative analysis of a novel antimicrobial peptide in rat plasma by ultra perf or mance liquid chromat ography–tandem mass spectrometry[J].J Pharmaceut Biomed,2011,1(3):191-196.
[41]Thamasirirak SP,Pukcothanung Y,Preecharram S,et al.Antimicrobial peptides derived from goose egg white lysozyme[J].Comp Biochem Phys C,2010,151:84-91.
[2]王大勇.综述抗菌肽在制药工程中的应用机理及发展[J].科技与企业,2013,4:287.
[3]Gaspar D,Veiga AS,Castanho MARB.From antimicrobial to anticancer peptides a review[J].Front Microbiol,2013,4:294.
[4]郭斌,谢宁,白珊珊,等.抗菌肽MUC7联合双歧杆菌体外抗真菌研究[J].重庆医学,2015,44(03):309-311.
[5]Torrent M,Pulido D,Rivas L,et al.Antimicrobial peptide action on parasites[J].Curr Drug Targets,2012,13(9):1138-1147.
[6]代玉华,霍红杰,王怀位,等.抗菌肽抗疟原虫作用的研究进展[J].中国寄生虫学与寄生虫病杂志,2010,28(06):455-458.
[7]Hsieh IN,Hartshorn KL.The role of antimicrobial peptides in influenza virus infection and their potential as antiviral and immunomodulatory therapy[J].Pharmaceuticals,2016,9:53.
[8]赵洁,孙燕,李晶,等.动物抗菌肽的抗病毒活性[J].医学分子生物学杂志,2008,5:466-469.
[9]Chu HL,Yip BS,Chen KH,et al.Novel antimicrobial peptides with high anticancer activity and selectivity[J].Plo S One,2015,10(5):e0126390.
[10]许洪杰,张云杰.抗菌肽在水产养殖中的应用前景[J].科学养鱼,2016,6:87.
[11]关静姝,李波.综述抗菌肽的生物学功能[J].饲料与畜牧,2013,9:60-61.
[12]Gordon YJ,Romanowski EG.A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs[J].Curr Eye Res,2015,30(7):505-515.
[13]Marr AK,Gooderham WJ,Hancock REW.Antibacterial peptides for therapeutic use:obstacles and realistic outlook[J].Curr Opin Pharmacol,2006,6:468-472.
[14]Rai M,Pandit R,Gaikwad S,et al.Antimicrobial peptides as natural bio-preservative to enhance the shelf-life of food[J].J Food Sci Technol,2016,53:3381-3394.
[15]郭晓敏.抗菌肽的融合表达及其生物活性的初步研究[D].浙江理工大学,2012.
[16]苗建银,柯畅,郭浩贤,等.抗菌肽的提取分离及抑菌机理研究进展[J].现代食品科技,2014,30(01):233-240.
[17]陈飞龙.Lactobacillus paracasei FX-6产抗菌肽对金黄色葡萄球菌作用机制及其应用研究[D].华南农业大学,2016.
[18]宋贤丽.茳芒决明抗菌蛋白的分离纯化及当归和六种决明属植物的毛细管电泳指纹图谱[D].四川大学,2003.
[19]张先文,张伟,赵小凡,等.家蝇天然抗菌肽的分离纯化与活性分析[J].生物技术,2007,(02):51-54.
[20]江惠.竹叶天然抗菌肽的分离纯化、抑菌活性与抑菌机理研究[D].西华大学,2011.
[21]齐珂珂,康相涛,韩瑞丽,等.鸵鸟异嗜白细胞抗菌肽的分离、纯化及部分性质分析[J].农业生物技术学报,2009,17(03):455-461.
[22]胡建和,杭柏林,王青,等.牛红细胞源抗菌肽的分离纯化与活性鉴定[J].西北农林科技大学学报(自然科学版),2010,38(02):36-40.
[23]胡建和.牛血液红细胞中抗菌肽的纯化及抗菌活性的初步鉴定[A].中国畜牧兽医学会,2009:4.
[24]王延卓.猪血中抗菌肽的提取及体外抗菌活性研究[D].吉林农业大学,2007.
[25]樊陈,高兆建,张桂英,等.地衣芽孢杆菌抗菌肽的纯化及抗菌特性分析[J].中国农学通报,2013,29(33):313-318.
[26]潘顺,刘雷,付贤树,等.高效液相色谱-质谱联用法高通量筛选及检测哈茨木霉菌发酵液中pep-taibols类抗菌肽[J].中国药学杂志,2012,47(22):1849-1855.
[27]Huang YB,Pan Li,Zhao LJ,et al.Structure guided RPHPLC chromatography of diastereomericα-helical peptide analogs substituted with single amino acid stereoisomers[J].Biomed Chromatogr,2015,28:511-517.
[28]Song R,WeiRB,LuoHY,et al.Isolation and characterization of an antibacterial peptide fraction from the pepsin hydrolysate of Half-Fin anchovy[J].Molecules,2012,17:2980-2991.
[29]Wong JH,Dcw Ip,Ng TB,et al.A defensin-like peptide from Phaseolus vulgaris cv.‘King Pole Bean’[J].Food Chem,2012,135:408-414.
[30]Capriotti AL,Cavaliere C,Piovesana S,et al.Recent trends in the analysis of bioactive peptides in milk and dairy products[J].Anal Bioanal Chem,2016,408:2677-2685.
[31]Kelly GJ,Kia AFA,Hassan F,et al.Polymeric prodrug combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells[J].Org Biomol Chem,2016,14:9278.
[32]Belal JM,Zaiton H,Fatimah ABr,et al.Identification of antifungal peptides produced by Lactobacillus plantarum IS10 grown in the MRS broth[J].Food Control,2016,59:27-30.
[33]Buszewski B,Noga S.Hydrophilic interaction liquid chromatography(HILIC)-apowerful separation technique[J].Anal Bioanal Chem,2012,402:231-247.
[34]Colin TM,Robert SH.Mixed-mode hydrophilic interaction/cation-exchange chromatography(HILIC/CEX)of peptides and proteins[J].J Sep Sci,2008,31:2754-2773.
[35]Surugau LN.Peptide separation by capillary electrophoresis with ultraviolet detection:some simple approaches to enhance detection sensitivity and resolution[J].Zeolites,2011,15(4):245-250.
[36]Tang WT,Pu CF,Man Li,et al.Interaction between antibacterial peptide apep10 and escherichia coli membrane lipids evaluated using liposome as pseudo Stationary phase[J].Plo S One,12:e0164594.
[37]Zhu ZF,Lu JJ,Liu SR.Protein separation by capillary gel electrophoresis:a review[J].Anal Chim Acta,2012,709:21-31.
[38]Guillo C,Barlow D,Perrett D,et al.Micellar electrokinetic capillary chromatography and data alignment analysis:a new tool in urine profiling[J].J Chromatogr A,2004,1027:203-212.
[39]RighettiR G,Sebastiano R,Citterio A.Capillary electrophoresis and isoelectric focusing in peptide and protein analysis[J].Proteomics,2013,13:325.
[40]Zhang RW,Liu WT,Geng LL,et al.Quantitative analysis of a novel antimicrobial peptide in rat plasma by ultra perf or mance liquid chromat ography–tandem mass spectrometry[J].J Pharmaceut Biomed,2011,1(3):191-196.
[41]Thamasirirak SP,Pukcothanung Y,Preecharram S,et al.Antimicrobial peptides derived from goose egg white lysozyme[J].Comp Biochem Phys C,2010,151:84-91.