老年男性代谢综合征患者血脂肪酸结合蛋白4与脂质代谢及体脂分布的相关性
摘要
目的探讨老年男性代谢综合征(MS)患者血清中脂肪酸结合蛋白(FABP)4与脂质代谢及体脂分布的相关性。方法收集60~85岁老年男性122例,分为MS组72例、非MS组50例。按照MS组分数目分为5组:1组(0组分)、2组(1组分)、3组(2组分)、4组(3组分)、5组(≥4组分)。采用ELISA方法检测血清中FABP4水平,生物电阻抗法测定人体体脂百分比及腰臀脂肪比评估体脂分布情况及肥胖程度,分析FABP4与各脂质代谢指标及体脂分布的相关性。结果 MS组FABP4水平较非MS组显著升高〔(31.44±15.08)ng/ml vs(24.56±5.60)ng/ml,P<0.01〕,随代谢组分增加,FABP4水平呈逐渐升高趋势(P<0.01)。相关性分析表明血清FABP4与体重指数(BMI)、体脂百分比、腰臀脂肪比、甘油三酯(TG)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(Hb A1c)均呈正相关(r分别为0.798、0.493、0.720、0.333、0.553、0.267、0.467和0.470,均P<0.01)。多元线性逐步回归分析显示BMI、FPG、腰臀脂肪比、体脂百分比、舒张压是影响血清FABP4的独立危险因素(b=0.596、0.240、0.325、-0.155、-0.148,均P<0.05)。结论血清中FABP4高水平可增加老年男性MS风险,并参与脂质代谢紊乱及体脂的异常分布特别是腹型肥胖的形成。
引文
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2 Smith AJ,Sanders MA,Thompson BR,et al.Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase:a fluorescence resonance energy transfer analysis[J].J Biol Chem,2004;279(50):52399-405.
3李楠,刘敏燕,裴育,等.老年男性糖代谢异常合并代谢综合征患者体脂分布特点分析[J].中华老年心脑血管病杂志,2011;13(12):1067-9.
4宋克群,于慧玲,冯长顺,等.老年男性代谢综合征患者体脂分布[J].中国老年学杂志,2014;34(8):2282-3.
5 Xu A,Wang Y,Xu JY,et al.Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome[J].Clin Chem,2006;52(3):405-13.
6 Koh JH,Shin YG,Nam SM,et al.Serum adipocyte fatty acid binding protein levels are associated with nonalcoholic fatty liver disease in type 2 diabetic patients[J].Diabetes Care,2009;32(1):147-52.
7 CabréA,Babio N,Lázaro I,et al.FABP4 predicts atherogenic dyslipidemia development.The PREDIMED study[J].Atherosclerosis,2012;222(1):229-34.
8 Kim SJ,Chae S,Kim H,et al.A protein profile of visceral adipose tissues linked to early pathogenesis of type 2 diabetes mellitus[J].Mol Cell Proteomics,2014;13(3):811-22.
9 Djousse L,Gaziano JM.Plasma levels of FABP4,but not FABP3 are associated with increased risk of diabetes[J].Lipids,2012;47(8):757-62.
10 Tso AW,Xu A,Sham PC,et al.Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes:a10-year prospective study in a Chinese cohort[J].Diabetes Care,2007;30(10):2667-72.
11 Camargo A,Meneses ME,Perez-Martinez P,et al.Dietary fat differentially influences the lipids storage on the adipose tissue in metabolic syndrome patients[J].Eur J Nutr,2014;53(2):617-26.
12 Syamsunarno MR,Iso T,Yamaquchi A,et al.Fatty acid binding protein4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress[J].PLo S ONE,2014;9(3):e90825.
13皇甫建,徐焱成,李彩萍,等.糖调节受损及初发2型糖尿病患者外周血脂肪细胞型脂肪酸结合蛋白4及人第10号染色体缺失的磷酸酶及张力蛋白同源物水平变化及与胰岛素抵抗的相关性[J].中华糖尿病杂志,2014;6(9):660-4.