甲状旁腺激素延缓椎间盘退行性变机制的研究进展
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摘要
<正>甲状旁腺激素(PTH)在骨代谢过程中发挥着双重调节作用,已广泛应用于骨质疏松症及预防骨质疏松性骨折的治疗~([1-2])。既往认为PTH为骨形成促进剂,在骨合成及分解代谢过程中起着关键作用;低剂量间断给药能提高绝经后骨质疏松妇女骨密度及改善骨质量,降低其骨折发生率~([3])。椎间盘退行性变(IDD)引起的疾病严重影响患者生活质量,其中椎间盘源性下腰痛占慢性腰背部疼痛的65%~([4])。约80%的成年人经历过不同程度的下腰痛~([5])。有研究发现,PTH不仅可以治疗骨质疏松,而且在延
引文
[1]Sato M,Westmore M,Ma Y L,et al.Teriparatide[PTH(1-34)]strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity[J].JBone Miner Res,2004,19(4):623-629.
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[3]卓苏铵.重组人甲状旁腺激素治疗绝经后骨质疏松妇女234例临床研究[J].中国妇幼保健,2012,27(8):1178-1180.
[4]Cohen SP,Larkin T,Fant GV,et al.Does needle insertion site affect diskography results?A retrospective analysis[J].Spine(Phila Pa 1976),2002,27(20):2279-2283.
[5]Ivanova JI,Birnbaum HG,Schiller M,et al.Real-world practice patterns,health-care utilization,and costs in patients with low back pain:the long road to guidelineconcordant care[J].Spine J,2011,11(7):622-632.
[6]蔡金生,张柳,王文雅,等.甲状旁腺素(1-34)对卵巢切除大鼠腰椎间盘退行性变的影响[J].解剖学杂志,2011,34(6):739-742.
[7]张婷婷,庞田田,李游山,等.甲状旁腺激素的基因表达调控[J].生理科学进展,2016,47(3):231-234.
[8]刘立,王银河.甲状旁腺激素和甲状旁腺激素相关肽对骨形成作用的研究进展[J].成都医学院学报,2016,11(3):387-390.
[9]刘长永.甲状旁腺激素和阿仑膦酸钠对男性骨质疏松患者骨密度的影响[J].中国老年学杂志,2015,35(7):1972-1973.
[10]原发性骨质疏松症诊疗指南(2017)[J].临床医学研究与实践,2017,2(31):201.
[11]徐进,荣海钦,王东,等.人甲状旁腺激素相关蛋白片段对骨质疏松大鼠股骨和腰椎骨密度的影响[J].中国老年学杂志,2006(1):51-54.
[12]Kaback LA,Soung do Y,Naik A,et al.Teriparatide(1-34 human PTH)regulation of osterix during fracture repair[J].J Cell Biochem,2008,105(1):219-226.
[13]中华医学会骨科学分会骨质疏松学组.骨质疏松性骨折诊疗指南[J].中华骨科杂志,2017,37(1):1-10.
[14]贾永建,宋洁富,荆志振.腰椎间盘退变和骨密度的相关性分析[J].中国骨质疏松杂志,2016,22(4):471-474.
[15]Yang Z,Griffith JF,Leung PC,et al.Effect of osteoporosis on morphology and mobility of the lumbar spine[J].Spine(Phila Pa 1976),2009,34(3):E115-E121.
[16]Howe KS,Iwaniec UT,Turner RT.The effects of low dose parathyroid hormone on lumbar vertebrae in a rat model for chronic alcohol abuse[J].Osteoporos Int,2011,22(4):1175-1181.
[17]Sehmisch S,Erren M,Rack T,et al.Short-term effects of parathyroid hormone on rat lumbar vertebrae[J].Spine(Phila Pa 1976),2009,34(19):2014-2021.
[18]刘桓江.PTH(1-34)对豚鼠自发性腰椎间盘退变的影响[D].唐山:河北联合大学,2014.
[19]O’Connell GD,Vresilovic EJ,Elliott DM.Human intervertebral disc internal strain in compression:the effect of disc region,loading position,and degeneration[J].J Orthop Res,2011,29(4):547-555.
[20]Gregory DE,Callaghan J P.A comparison of uniaxial and biaxial mechanical properties of the annulus fibrosus:a porcine model[J].J Biomech Eng,2011,133(2):024503.
[21]肖扬,王万春.细胞因子与骨质疏松症[J].中国临床康复,2006(32):126-129.
[22]尚琦松,黄擘,盛文辉,等.炎性因子TNF-α及IL-18与椎间盘退变的相关性研究[J].中国矫形外科杂志,2009,17(5):385-387.
[23]Lugo L,Villalvilla A,Gómez R,et al.Effects of PTH[1-34]on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis[J].Osteoarthritis Cartilage,2012,20(12):1619-1630.
[24]Studer RK,Vo N,Sowa G,et al.Human nucleus pulposus cells react to IL-6:independent actions and amplification of response to IL-1 and TNF-α[J].Spine(Phila Pa 1976),2011,36(8):593-599.
[25]Jia H,Ma J,Lv J,et al.Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity[J].Sci Rep,2016,6:27521.
[26]夏铎.腰痹舒对兔椎间盘退变髓核组织TNF-α、MMP-1及TIMP-1表达的影响[D].衡阳:南华大学,2013.
[27]Kohyama K,Saura R,Doita M,et al.Intervertebral disc cell apoptosis by nitric oxide:biological understanding of intervertebral disc degeneration[J].Kobe J Med Sci,2000,46(6):283-295.
[28]Rannou F,Richette P,Benallaoua M,et al.Cyclic tensile stretch modulates proteoglycan production by intervertebral disc annulus fibrosus cells through production of nitrite oxide[J].J Cell Biochem,2003,90(1):148-157.
[29]Weiler C,Nerlich AG,Schaaf R,et al.Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc[J].Eur Spine J,2010,19(10):1761-1770.
[30]彭宝淦,施杞,沈培芝,等.软骨终板钙化与椎间盘退变关系的实验研究[J].中华外科杂志,1999,37(10):613-616.
[31]丁寅.骨质疏松与椎间盘退变对椎体软骨终板损伤影响的大鼠实验研究[D].广州:南方医科大学,2013.
[32]Madiraju P,Gawri R,Wang H,et al.Mechanism of parathyroid hormone-mediated suppression of calcification markers in human intervertebral disc cells[J].Eur Cell Mater,2013,25:268-283.
[33]田野,徐莹,付勤.甲状旁腺素促进小鼠软骨细胞成软骨和抑制其终末期分化的实验研究[J].中国组织化学与细胞化学杂志,2013,22(5):421-425.
[34]Sakai D.Future perspectives of cell-based therapy for intervertebral disc disease[J].Eur Spine J,2008,17(Suppl 4):452-458.
[35]Pereira CL,Teixeira GQ,Ribeiro-Machado C,et al.Mesenchymal stem/stromal cells seeded on cartilaginous endplates promote intervertebral disc regeneration through extracellular matrix remodeling[J].Sci Rep,2016,6:33836.
[36]Kamper M,Paulsson M,Zaucke F.Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the IhhPTHrP feedback loop[J].Cell Tissue Res,2017,367(2):359-367.
[37]Hwang PY,Jing L,Michael KW,et al.N-cadherinmediated signaling regulates cell phenotype for nucleus pulposus cells of the intervertebral disc[J].Cell Mol Bioeng,2015,8(1):51-62.
[38]Moon HJ,Joe H,Kwon TH,et al.Notochordal cells influence gene expression of inflammatory mediators of annulus fibrosus cells in proinflammatory cytokines stimulation[J].J Korean Neurosurg Soc,2010,48(1):1-7.
[39]Erwin WM,Islam D,Inman RD,et al.Notochordal cells protect nucleus pulposus cells from degradation and apoptosis:implications for the mechanisms of intervertebral disc degeneration[J].Arthritis Res Ther,2011,13(6):R215.
[40]Risbud MV,Shapiro IM.Notochordal cells in the adult intervertebral disc:new perspective on an old question[J].Crit Rev Eukaryot Gene Expr,2011,21(1):29-41.
[41]Park EY,Park JB.High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells[J].Int Orthop,2013,37(12):2507-2514.
[2]Osagie-Clouard L,Sanghani A,Coathup M,et al.Parathyroid hormone 1-34 and skeletal anabolic action:the use of parathyroid hormone in bone formation[J].Bone Joint Res,2017,6(1):14-21.
[3]卓苏铵.重组人甲状旁腺激素治疗绝经后骨质疏松妇女234例临床研究[J].中国妇幼保健,2012,27(8):1178-1180.
[4]Cohen SP,Larkin T,Fant GV,et al.Does needle insertion site affect diskography results?A retrospective analysis[J].Spine(Phila Pa 1976),2002,27(20):2279-2283.
[5]Ivanova JI,Birnbaum HG,Schiller M,et al.Real-world practice patterns,health-care utilization,and costs in patients with low back pain:the long road to guidelineconcordant care[J].Spine J,2011,11(7):622-632.
[6]蔡金生,张柳,王文雅,等.甲状旁腺素(1-34)对卵巢切除大鼠腰椎间盘退行性变的影响[J].解剖学杂志,2011,34(6):739-742.
[7]张婷婷,庞田田,李游山,等.甲状旁腺激素的基因表达调控[J].生理科学进展,2016,47(3):231-234.
[8]刘立,王银河.甲状旁腺激素和甲状旁腺激素相关肽对骨形成作用的研究进展[J].成都医学院学报,2016,11(3):387-390.
[9]刘长永.甲状旁腺激素和阿仑膦酸钠对男性骨质疏松患者骨密度的影响[J].中国老年学杂志,2015,35(7):1972-1973.
[10]原发性骨质疏松症诊疗指南(2017)[J].临床医学研究与实践,2017,2(31):201.
[11]徐进,荣海钦,王东,等.人甲状旁腺激素相关蛋白片段对骨质疏松大鼠股骨和腰椎骨密度的影响[J].中国老年学杂志,2006(1):51-54.
[12]Kaback LA,Soung do Y,Naik A,et al.Teriparatide(1-34 human PTH)regulation of osterix during fracture repair[J].J Cell Biochem,2008,105(1):219-226.
[13]中华医学会骨科学分会骨质疏松学组.骨质疏松性骨折诊疗指南[J].中华骨科杂志,2017,37(1):1-10.
[14]贾永建,宋洁富,荆志振.腰椎间盘退变和骨密度的相关性分析[J].中国骨质疏松杂志,2016,22(4):471-474.
[15]Yang Z,Griffith JF,Leung PC,et al.Effect of osteoporosis on morphology and mobility of the lumbar spine[J].Spine(Phila Pa 1976),2009,34(3):E115-E121.
[16]Howe KS,Iwaniec UT,Turner RT.The effects of low dose parathyroid hormone on lumbar vertebrae in a rat model for chronic alcohol abuse[J].Osteoporos Int,2011,22(4):1175-1181.
[17]Sehmisch S,Erren M,Rack T,et al.Short-term effects of parathyroid hormone on rat lumbar vertebrae[J].Spine(Phila Pa 1976),2009,34(19):2014-2021.
[18]刘桓江.PTH(1-34)对豚鼠自发性腰椎间盘退变的影响[D].唐山:河北联合大学,2014.
[19]O’Connell GD,Vresilovic EJ,Elliott DM.Human intervertebral disc internal strain in compression:the effect of disc region,loading position,and degeneration[J].J Orthop Res,2011,29(4):547-555.
[20]Gregory DE,Callaghan J P.A comparison of uniaxial and biaxial mechanical properties of the annulus fibrosus:a porcine model[J].J Biomech Eng,2011,133(2):024503.
[21]肖扬,王万春.细胞因子与骨质疏松症[J].中国临床康复,2006(32):126-129.
[22]尚琦松,黄擘,盛文辉,等.炎性因子TNF-α及IL-18与椎间盘退变的相关性研究[J].中国矫形外科杂志,2009,17(5):385-387.
[23]Lugo L,Villalvilla A,Gómez R,et al.Effects of PTH[1-34]on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis[J].Osteoarthritis Cartilage,2012,20(12):1619-1630.
[24]Studer RK,Vo N,Sowa G,et al.Human nucleus pulposus cells react to IL-6:independent actions and amplification of response to IL-1 and TNF-α[J].Spine(Phila Pa 1976),2011,36(8):593-599.
[25]Jia H,Ma J,Lv J,et al.Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity[J].Sci Rep,2016,6:27521.
[26]夏铎.腰痹舒对兔椎间盘退变髓核组织TNF-α、MMP-1及TIMP-1表达的影响[D].衡阳:南华大学,2013.
[27]Kohyama K,Saura R,Doita M,et al.Intervertebral disc cell apoptosis by nitric oxide:biological understanding of intervertebral disc degeneration[J].Kobe J Med Sci,2000,46(6):283-295.
[28]Rannou F,Richette P,Benallaoua M,et al.Cyclic tensile stretch modulates proteoglycan production by intervertebral disc annulus fibrosus cells through production of nitrite oxide[J].J Cell Biochem,2003,90(1):148-157.
[29]Weiler C,Nerlich AG,Schaaf R,et al.Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc[J].Eur Spine J,2010,19(10):1761-1770.
[30]彭宝淦,施杞,沈培芝,等.软骨终板钙化与椎间盘退变关系的实验研究[J].中华外科杂志,1999,37(10):613-616.
[31]丁寅.骨质疏松与椎间盘退变对椎体软骨终板损伤影响的大鼠实验研究[D].广州:南方医科大学,2013.
[32]Madiraju P,Gawri R,Wang H,et al.Mechanism of parathyroid hormone-mediated suppression of calcification markers in human intervertebral disc cells[J].Eur Cell Mater,2013,25:268-283.
[33]田野,徐莹,付勤.甲状旁腺素促进小鼠软骨细胞成软骨和抑制其终末期分化的实验研究[J].中国组织化学与细胞化学杂志,2013,22(5):421-425.
[34]Sakai D.Future perspectives of cell-based therapy for intervertebral disc disease[J].Eur Spine J,2008,17(Suppl 4):452-458.
[35]Pereira CL,Teixeira GQ,Ribeiro-Machado C,et al.Mesenchymal stem/stromal cells seeded on cartilaginous endplates promote intervertebral disc regeneration through extracellular matrix remodeling[J].Sci Rep,2016,6:33836.
[36]Kamper M,Paulsson M,Zaucke F.Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the IhhPTHrP feedback loop[J].Cell Tissue Res,2017,367(2):359-367.
[37]Hwang PY,Jing L,Michael KW,et al.N-cadherinmediated signaling regulates cell phenotype for nucleus pulposus cells of the intervertebral disc[J].Cell Mol Bioeng,2015,8(1):51-62.
[38]Moon HJ,Joe H,Kwon TH,et al.Notochordal cells influence gene expression of inflammatory mediators of annulus fibrosus cells in proinflammatory cytokines stimulation[J].J Korean Neurosurg Soc,2010,48(1):1-7.
[39]Erwin WM,Islam D,Inman RD,et al.Notochordal cells protect nucleus pulposus cells from degradation and apoptosis:implications for the mechanisms of intervertebral disc degeneration[J].Arthritis Res Ther,2011,13(6):R215.
[40]Risbud MV,Shapiro IM.Notochordal cells in the adult intervertebral disc:new perspective on an old question[J].Crit Rev Eukaryot Gene Expr,2011,21(1):29-41.
[41]Park EY,Park JB.High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells[J].Int Orthop,2013,37(12):2507-2514.