长链非编码RNA 在自身免疫性疾病中的研究进展
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摘要
长链非编码RNA(lncRNA)是一类长度超过200 nt的非编码RNA。lncRNA可在生命活动的多个水平调控基因表达从而影响生物学过程。lncRNA与免疫细胞活动密切相关,能够通过调控免疫细胞分化发育以及免疫细胞效应功能参与自身免疫性疾病的发生发展。
Long non-coding RNAs(lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. Studies have shown that lncRNAs participate in chromatin modification and pre/post-transcriptional regulation to regulate the expression of multiple genes. In recent years, studies have shown that lncRNAs play critical roles inthe development of autoimmune diseases by regulating the differentiation and function of immune cells.
Long non-coding RNAs(lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. Studies have shown that lncRNAs participate in chromatin modification and pre/post-transcriptional regulation to regulate the expression of multiple genes. In recent years, studies have shown that lncRNAs play critical roles inthe development of autoimmune diseases by regulating the differentiation and function of immune cells.
引文
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[19] Spurlock CF, Tossberg JT, Matlock BK, et al. Methotrexate inhibits NF-kappaB activity via long intergenic (noncoding) RNA-p21 induction [J]. Arthritis Rheumatol, 2014, 66: 2947-2957.
[20] Ye Z, Xu J, Li S, et al. LncIL7R promotes the growth of fibroblastlike synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis [J]. Mol Med Rep, 2017, 15: 1412-1418.
[21] Julia A, Lopez-Longo FJ, Perez Venegas JJ, et al. Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus [J]. Arthritis Res Ther, 2018, 20: 100.
[22] Lucafo M, De Iudicibus S, Di Silvestre A, et al. Long noncoding RNA GAS5: a novel marker involved in glucocorticoid response [J]. Curr Mol Med, 2015, 15: 94-99.
[23] Denton CP, Khanna D. Systemic sclerosis [J]. Lancet, 2017, 390: 1685-1699.
[24] Wang Z, Jinnin M, Nakamura K, et al. Long non-coding RNA TSIX is upregulated in scleroderma dermal fibro-blasts and controls collagen mRNA stabilization [J]. Exp Dermatol, 2016, 25: 131-136.
[25] Zhang F, Liu G, Wei C, et al. Linc-MAF-4 regulates Th1/Th2 differentiation and is associated with the pathogenesis of multiple sclerosis by targeting MAF [J]. FASEB J, 2017, 31: 519-525.
[2] Bonasio R, Shiekhattar R. Regulation of transcription by long noncoding RNAs [J]. Annu Rev Genet, 2014, 48: 433-455.
[3] Iyer MK, Niknafs YS, Malik R, et al. The landscape of long noncoding RNAs in the human transcriptome [J]. Nat Genet, 2015, 47: 199-208.
[4] Tani H, Mizutani R, Salam KA, et al. Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals [J]. Genome Res, 2012, 22: 947-956.
[5] Wu GC, Pan HF, Leng RX, et al. Emerging role of long noncoding RNAs in autoimmune diseases [J]. Autoimmun Rev, 2015, 14: 798-805.
[6] Atianand MK, Fitzgerald KA. Long non-coding RNAs and control of gene expression in the immune system [J]. Trends mol med, 2014, 20: 623-631.
[7] Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development [J]. Nat Rev Genet, 2014, 15: 7-21.
[8] Pontier DB, Gribnau J. Xist regulation and function explored [J]. Hum Genet, 2011, 130: 223-236.
[9] Wang LP, Wang JP, Wang XP. HOTAIR contributes to the growth of liver cancer via targeting miR-217 [J]. Oncol Lett, 2018, 15: 7963-7972.
[10] Loewer S, Cabili MN, Guttman M, et al. Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells [J]. Nat Genet, 2010, 42: 1113-1117.
[11] Li Y, Syed J, Sugiyama H. RNA-DNA Triplex Formation by Long Noncoding RNAs [J]. Cell Chem Biol, 2016, 23: 1325-1333.
[12] Lee N, Moss WN, Yario TA, et al. EBV noncoding RNA binds nascent RNA to drive host PAX5 to viral DNA [J]. Cell, 2015, 160: 607-618.
[13] Morchikh M, Cribier A, Raffel R, et al. HEXIM1 and NEAT1 long non-coding RNA form a multi-subunit com-plex that regulates DNA-mediated innate immune response [J]. Mol Cell, 2017, 67: 387-399.
[14] Aune TM, Crooke PS, Patrick AE, et al. Expression of long non-coding RNAs in autoimmunity and linkage to enhancer function and autoimmune disease risk genetic variants [J]. J Autoimmun, 2017, 81:99-109.
[15] Xia M, Liu J, Liu S, et al. Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity [J]. Nat Commun, 2017, 8:15818.
[16] Huang W, Thomas B, Flynn RA, et al. DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions [J]. Nature, 2015, 528: 517-522.
[17] McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis [J]. N Eng J Med, 2011, 365: 2205-2219.
[18] Song J, Kim D, Han J, et al. PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis [J]. Clin Exp Med, 2015, 15: 121-126.
[19] Spurlock CF, Tossberg JT, Matlock BK, et al. Methotrexate inhibits NF-kappaB activity via long intergenic (noncoding) RNA-p21 induction [J]. Arthritis Rheumatol, 2014, 66: 2947-2957.
[20] Ye Z, Xu J, Li S, et al. LncIL7R promotes the growth of fibroblastlike synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis [J]. Mol Med Rep, 2017, 15: 1412-1418.
[21] Julia A, Lopez-Longo FJ, Perez Venegas JJ, et al. Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus [J]. Arthritis Res Ther, 2018, 20: 100.
[22] Lucafo M, De Iudicibus S, Di Silvestre A, et al. Long noncoding RNA GAS5: a novel marker involved in glucocorticoid response [J]. Curr Mol Med, 2015, 15: 94-99.
[23] Denton CP, Khanna D. Systemic sclerosis [J]. Lancet, 2017, 390: 1685-1699.
[24] Wang Z, Jinnin M, Nakamura K, et al. Long non-coding RNA TSIX is upregulated in scleroderma dermal fibro-blasts and controls collagen mRNA stabilization [J]. Exp Dermatol, 2016, 25: 131-136.
[25] Zhang F, Liu G, Wei C, et al. Linc-MAF-4 regulates Th1/Th2 differentiation and is associated with the pathogenesis of multiple sclerosis by targeting MAF [J]. FASEB J, 2017, 31: 519-525.