富血小板血浆和透明质酸注射在治疗膝关节轻中度骨关节炎中的疗效对比
摘要
目的对比富血小板血浆(PRP)和透明质酸(HA)注射治疗膝关节轻、中度骨关节炎的临床疗效。方法选取膝关节轻中度骨关节炎患者100例,随机分为PRP组和HA组,各50例。PRP组抽取外周静脉血50 ml制备PRP 8 ml注入膝关节腔,HA组关节腔内注射2.5 ml HA。记录两组注射后不良反应情况,采用Ontario与McMaster大学骨关节炎指数(WOMAC)评分评定膝关节功能恢复情况,采用疼痛视觉模拟评分(VAS)评估疼痛缓解情况。结果两组1、3、6及12个月VAS评分差异均有统计学意义(均<0.05);两组12个月时日常活动评分差异有统计学意义(<0.05)。结论 PRP注射治疗膝关节骨关节炎在疼痛缓解和部分功能改善方面具有优势,可作为对常规治疗无效的骨关节炎患者的一种治疗选择。
引文
[1] Michael JWP, Schlüter-Brust KU, Eysel P.The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee[J].Dtsch Arztebl Int, 2010,107(9):152-162.
[2] Bannuru RR, Vaysbrot EE, Sullivan MC,et al. Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis:a systematic review and meta-analysis[J].Semin Arthritis Rheum,2014,43(5):593-599.
[3] Van Buul GM, Koevoet WL, Kops N, et a1. Platelet-rich plastma releasateinhibits inflammatory processes in osteoarthritic chondrocytes[J].Am J SportsMed,2011,39(11):2362-2370.
[4] Handl M, Amler E, Br?un K, et al. Positive effect of oral supplement at ion with glycosaminoglycans and antioxidants on theregeneration ofosteochondral defectsin the knee joint[J].Physiol Res,2007, 56(2):243-249.
[5] Xie XT, Zhang CQ, Tuan RS. Biology of platelet-rich plasma and its clinical application in cartilage repair[J].Arthritis Res Ther,2014,16(1):204.
[6] Cerza F, Carol S, Carcangiu A, et a1.Comparinson between hyaluronic acidandplatelet-rich plasma intra-articular infiltration in the treatment of gonarthrosis[J]. Am J Sports Med,2012,40(12):2822-2827.
[7] Filardo G, Kon E, Di Martino A, et al. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology:study design and preliminary results of a randomized controlled trial[J].BMC Musculoskelet Disord, 2012,13(1):229.
[2] Bannuru RR, Vaysbrot EE, Sullivan MC,et al. Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis:a systematic review and meta-analysis[J].Semin Arthritis Rheum,2014,43(5):593-599.
[3] Van Buul GM, Koevoet WL, Kops N, et a1. Platelet-rich plastma releasateinhibits inflammatory processes in osteoarthritic chondrocytes[J].Am J SportsMed,2011,39(11):2362-2370.
[4] Handl M, Amler E, Br?un K, et al. Positive effect of oral supplement at ion with glycosaminoglycans and antioxidants on theregeneration ofosteochondral defectsin the knee joint[J].Physiol Res,2007, 56(2):243-249.
[5] Xie XT, Zhang CQ, Tuan RS. Biology of platelet-rich plasma and its clinical application in cartilage repair[J].Arthritis Res Ther,2014,16(1):204.
[6] Cerza F, Carol S, Carcangiu A, et a1.Comparinson between hyaluronic acidandplatelet-rich plasma intra-articular infiltration in the treatment of gonarthrosis[J]. Am J Sports Med,2012,40(12):2822-2827.
[7] Filardo G, Kon E, Di Martino A, et al. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology:study design and preliminary results of a randomized controlled trial[J].BMC Musculoskelet Disord, 2012,13(1):229.