中性粒细胞/淋巴细胞比值、前白蛋白对CAP患者入住ICU风险的临床应用
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摘要
①目的探讨中性粒细胞/淋巴细胞比值、前白蛋白对于预测社区获得性肺炎(CAP)患者入住重症监护室(ICU)风险的临床应用。②方法回顾性分析在华北理工大学附属医院入住的150例CAP成年患者,根据患者是否入住ICU,分为入住ICU组、非入住ICU组;分别比较各组患者入院当天中性粒细胞/淋巴细胞比值、前白蛋白情况,应用受试者工作特征曲线(ROC曲线)评价中性粒细胞/淋巴细胞比值、前白蛋白水平对于CAP患者的诊断效能。③结果与非入住ICU组相比,入住ICU组患者中性粒细胞/淋巴细胞比值增高,而前白蛋白水平降低;中性粒细胞/淋巴细胞比值、前白蛋白预测入住ICU风险的ROC曲线下面积分别为0.82(95%CI 0.74,0.89)、0.79(95%CI 0.71,0.88)。中性粒细胞/淋巴细胞比值暴露水平越高、前白蛋白暴露水平越低,CAP患者入住ICU风险越高(OR=0.5,0.04)。差异均有统计学意义(P<0.05)。④结论中性粒细胞/淋巴细胞比值增高、前白蛋白降低,CAP患者入住ICU的危险性增高。
Objective To explore the clinical application of neutrophil-to-lymphocyte ratio and prealbumin in predicting ICU risk in CAP patients.Methods Retrospective analysis of 150 adult CAP patients who were admitted to the affiliated hospital of north China university of technology.The neutrophil-to-lymphocyte ratio and proalbumin in each group were compared on the day of admission,and the diagnostic efficacof neutrophil-to-lymphocyte ratio and proalbumin level in CAP patients was evaluated by the subject's ROC curve.Results Compared with the non-ICU group,the neutrophil-to-lymphocyte ratio in the ICU group increased,while the level of pre-albumin decreased.The area under the ROC curve of neutrophil-to-lymphocyte ratio and pre-albumin predicted the risk of ICU admission was 0.82(95%CI 0.74, 0.89) and 0.79(95%CI 0.71,0.88),respectively.The higher the level of neutrophil-to-lymphocyte ratio exposure and the lower the level of pre-albumin exposure,the higher the risk of ICU admission in CAP patients(OR=0.5,0.04).The differences were statistically significant(P<0.05).Conclusion Increased neutrophil-to-lymphocyte ratio,decreased prealbumin, and increased risk of ICU admission in CAP patients.
Objective To explore the clinical application of neutrophil-to-lymphocyte ratio and prealbumin in predicting ICU risk in CAP patients.Methods Retrospective analysis of 150 adult CAP patients who were admitted to the affiliated hospital of north China university of technology.The neutrophil-to-lymphocyte ratio and proalbumin in each group were compared on the day of admission,and the diagnostic efficacof neutrophil-to-lymphocyte ratio and proalbumin level in CAP patients was evaluated by the subject's ROC curve.Results Compared with the non-ICU group,the neutrophil-to-lymphocyte ratio in the ICU group increased,while the level of pre-albumin decreased.The area under the ROC curve of neutrophil-to-lymphocyte ratio and pre-albumin predicted the risk of ICU admission was 0.82(95%CI 0.74, 0.89) and 0.79(95%CI 0.71,0.88),respectively.The higher the level of neutrophil-to-lymphocyte ratio exposure and the lower the level of pre-albumin exposure,the higher the risk of ICU admission in CAP patients(OR=0.5,0.04).The differences were statistically significant(P<0.05).Conclusion Increased neutrophil-to-lymphocyte ratio,decreased prealbumin, and increased risk of ICU admission in CAP patients.
引文
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[2] 董杰.ICU重症社区获得性肺炎临床特征和预后因素分析及预测模型的建立[D].广州:广州医学院,2011
[3] 冯成.NLR和D一二聚体在社区获得性肺炎病情及预后评估中的价值[D].温州:温州医学院,2011
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[5] 蔡川奇,林志鸿,蔺佩鸿,等.血清白蛋白和前白蛋白对老年肺炎病情的预测价值[J].中国老年学杂志,2014,34(1):103-105