Mondo蛋白在肿瘤相关代谢中的研究进展
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摘要
转录因子Mondo蛋白家族包括MondoA和ChREBP(MondoB)两个家族成员,是葡萄糖介导的基因转录调控的关键调控因子,可直接调控糖酵解和脂肪酸生成相关基因的表达,在细胞代谢与能量平衡中发挥重要作用。细胞代谢改变是肿瘤的重要特征之一,为肿瘤细胞生长及恶性进展创造了有利条件。近年来,研究发现,Mondo蛋白在肿瘤细胞糖酵解、脂肪酸合成和谷氨酰胺利用等代谢通路中发挥着重要作用,而且Mondo蛋白调控肿瘤细胞的代谢,其在肿瘤细胞生长、增殖和侵袭等过程中的作用值得肿瘤研究者关注。因此,更好地认识Mondo蛋白调控肿瘤细胞代谢的机制,将为癌症的治疗提供新的方向。本文对Mondo蛋白家族成员的分子特征、表达调控、组织特异性功能及其在肿瘤代谢重编程和细胞增殖中的最新研究进行综述,为肿瘤的防治提供新思路。
The Mondo protein family, as transcription regulators, include two members: MondoA and ChREBP(MondoB), which are key regulators for glucose-mediated gene transcription that can directly regulate the expression of genes related to glycolysis and lipogenesis, and play an important role in cell metabolism and energy balance. Cellular metabolic alteration is one of the important characteristics of tumors, and creates favorable conditions for tumor cell growth and malignant progression. Recent studies have shown that Mondo proteins played important roles in metabolic pathways such as glycolysis, fatty acid synthesis, and glutamine utilization in tumor cells. And the role of Mondo proteins in the growth, proliferation and invasion of tumor cells by regulating the metabolism of tumor cells is worth of cancer researchers' attention. Further understanding of the mechanism that Mondo proteins regulate tumor metabolism will provide new directions for the treatment of cancer. This paper reviews the molecular characteristics, expression regulation, tissuespecific function of Mondo protein family members and their latest research in metabolic reprogramming and proliferation of tumor cells, which may provide novel ideas for the prevention and treatment of and tumors.
The Mondo protein family, as transcription regulators, include two members: MondoA and ChREBP(MondoB), which are key regulators for glucose-mediated gene transcription that can directly regulate the expression of genes related to glycolysis and lipogenesis, and play an important role in cell metabolism and energy balance. Cellular metabolic alteration is one of the important characteristics of tumors, and creates favorable conditions for tumor cell growth and malignant progression. Recent studies have shown that Mondo proteins played important roles in metabolic pathways such as glycolysis, fatty acid synthesis, and glutamine utilization in tumor cells. And the role of Mondo proteins in the growth, proliferation and invasion of tumor cells by regulating the metabolism of tumor cells is worth of cancer researchers' attention. Further understanding of the mechanism that Mondo proteins regulate tumor metabolism will provide new directions for the treatment of cancer. This paper reviews the molecular characteristics, expression regulation, tissuespecific function of Mondo protein family members and their latest research in metabolic reprogramming and proliferation of tumor cells, which may provide novel ideas for the prevention and treatment of and tumors.
引文
[1]吴彤,骆严.糖代谢重编程与肿瘤生长.生命的化学,2018,38(3):383-388
[2]Kishton RJ,Rathmell JC.Novel therapeutic targets of tumor metabolism.Cancer J,2015,21(2):62-69
[3]Ma L,Tsatsos NG,Towle HC.Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.JBiol Chem,2005,280(12):12019-12027
[4]Stoeckman AK,Ma L,Towle HC.Mlx is the functional heteromeric partner of the carbohydrate response elementbinding protein in glucose regulation of lipogenic enzyme genes.J Biol Chem,2004,279(15):15662-15669
[5]Havula E,Hietakangas V.Glucose sensing by ChREBP/MondoA-Mlx transcription factors.Semin.Cell Dev Biol,2012,23(6):640-647
[6]Richards P,Ourabah S,Montagne J,et al.MondoA/ChREBP:The usual suspects of transcriptional glucose sensing;Implication in pathophysiology.Metab Clin Exp,2017,70(1):133-151
[7]Nath A,Chan C.Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers.Sci Rep,2016,6(1):18669
[8]Dang CV.Web of the extended Myc network captures metabolism for tumorigenesis.Cancer Cell,2015,27(2):160-162
[9]Singh P,Irwin DM.Contrasting patterns in the evolution of vertebrate MLX interacting protein(MLXIP)and MLX interacting protein-like(MLXIPL)genes.PLoSOne,2016,11(2):e149682
[10]Ge Q,Nakagawa T,Wynn RM,et al.Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein(ChREBP).JBiol Chem,2011,286(32):28119-28127
[11]Yu FX,Luo Y.Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules.PLoSOne,2009,4(12):e8397
[12]崔潞晴,黄德玉,陆启荣,等.转录因子MondoA在糖代谢中的研究进展.动物医学进展,2018,39(3):97-102
[13]Davies MN,O'Callaghan BL,Towle HC.Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.J Biol Chem,2008,283(35):24029-24038
[14]Sans CL,Satterwhite DJ,Stoltzman CA,et al.MondoA-Mlx heterodimers are candidate sensors of cellular energy status:mitochondrial localization and direct regulation of glycolysis.Mol Cell Biol,2006,26(13):4863-4871
[15]Ma L,Sham YY,Walters KJ,et al.A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription.Nucleic Acids Res,2007,35(1):35-44
[16]Kabashima T,Kawaguchi T,Wadzinski BE,et al.Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.Proc Natl Acad Sci USA,2003,100(9):5107-5112
[17]Dentin R,Tomas-Cobos L,Foufelle F,et al.Glucose 6-phosphate,rather than xylulose 5-phosphate,is required for the activation of ChREBP in response to glucose in the liver.J Hepatol,2012,56(1):199-209
[18]Li MV,Chen W,Harmancey RN,et al.Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein(ChREBP).Biochem Biophys Res Commun,2010,395(3):395-400
[19]Stoltzman CA,Kaadige MR,Peterson CW,et al.MondoAsenses non-glucose sugars:regulation of thioredoxininteracting protein(TXNIP)and the hexose transport curb.J Biol Chem,2011,286(44):38027-38034
[20]Petrie JL,Al-Oanzi ZH,Arden C,et al.Glucose induces protein targeting to glycogen in hepatocytes by fructose2,6-bisphosphate-mediated recruitment of MondoA to the promoter.Mol Cell Biol,2013,33(4):725-738
[21]麦青,张雁.肿瘤代谢异质性的研究进展.中国细胞生物学学报,2017,40(6):786-795
[22]周鑫,王义平,徐莺莺,等.细胞代谢异常与肿瘤发生发展.生命的化学,2016,36(6):739-744
[23]Warburg O.On the origin of cancer cells.Science,1956,123(3191):309-314
[24]Hensley CT,Faubert B,Yuan Q,et al.Metabolic heterogeneity in human lung tumors.Cell,2016,164(4):681-694
[25]Hakimi AA,Reznik E,Lee CH,et al.An integrated metabolic atlas of clear cell renal cell carcinoma.Cancer Cell,2016,29(1):104-116
[26]Currie E,Schulze A,Zechner R,et al.Cellular fatty acid metabolism and cancer.Cell Metab,2013,18(2):153-161
[27]Stoltzman CA,Peterson CW,Breen KT,et al.Glucose sensing by MondoA:Mlx complexes:a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.Proc Natl Acad Sci USA,2008,105(19):6912-6917
[28]莫与琳,杨亚军,崔燎.TXNIP介导的氧化应激在疾病中的作用机制.中国药理学通报,2018,34(1):16-19
[29]Yu FX,Chai TF,He H,et al.Thioredoxin-interacting protein(Txnip)gene expression:sensing oxidative phosphorylation status and glycolytic rate.J Biol Chem,2010,285(33):25822-25830
[30]Wilde BR,Ayer DE.Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis.Br J Cancer,2015,113(11):1529-1533
[31]Shen L,O'Shea J M,Kaadige M R,et al.Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.Proc Natl Acad Sci USA,2015,112(17):5425-5430
[32]Parmenter TJ,Kleinschmidt M,Kinross KM,et al.Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis.Cancer Discov,2014,4(4):423-433
[33]Carroll PA,Diolaiti D,McFerrin L,et al.Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.Cancer Cell,2015,27(2):271-285
[34]Iizuka K.The transcription factor carbohydrate-response element-binding protein(ChREBP):A possible link between metabolic disease and cancer.Biochim Biophys Acta Mol Basis Dis,2017,1863(2):474-485
[35]Tong X,Zhao F,Mancuso A,et al.The glucose-responsive transcription factor ChREBP contributes to glucosedependent anabolic synthesis and cell proliferation.Proc Natl Acad Sci USA,2009,106(51):21660-21665
[36]Kaushik AK,Shojaie A,Panzitt K,et al.Inhibition of the hexosamine biosynthetic pathway promotes castrationresistant prostate cancer.Nat Commun,2016,7(5):11612
[37]Airley RE,McHugh P,Evans AR,et al.Role of carbohydrate response element-binding protein(ChREBP)in generating an aerobic metabolic phenotype and in breast cancer progression.Br J Cancer,2014,110(3):715-723
[38]Wang XL,Wen XF,Li RB,et al.Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer.Tumour Biol,2014,35(8):8143-8148
[39]Zeng H,Gu H,Chen C,et al.ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.Oncotarget,2016,7(25):38347-38358
[40]Jiang L,Xiao L,Sugiura H,et al.Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition.Oncogene,2015,34(30):3908-3916
[41]Jeong Y S,Kim D,Lee Y S,et al.Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.PLoS One,2011,6(7):e22544
[42]李博.肿瘤糖代谢紊乱的研究进展和探索.中山大学学报(医学科学版),2017,38(2):222-228
[43]萨日娜,武会娟.脂代谢通路及脂代谢异常在癌症中的研究现状.肿瘤防治研究,2016,43(10):907-912
[44]张国华,戴洪伟,卢建雄.转录因子ChREBP在葡萄糖诱导生脂中的作用.中国生物化学与分子生物学报,2016,32(3):245-252
[45]张明捷,陈寒蓓.转录因子碳水化合物反应元件结合蛋白研究进展.中国疗养医学,2018,27(8):800-805
[46]Peterson CW,Ayer DE.An extended Myc network contributes to glucose homeostasis in cancer and diabetes.Front Biosci(Landmark Ed),2011,16(6):2206-2223
[47]Ghasemi A,Aghajani H,Fallah S,et al.C771G(His-241Gln)polymorphism of MLXIPL gene,TG levels and coronary artery disease:a case control study.Anatol JCardiol,2015,15(1):8-12
[48]Aung LH,Yin RX,Wu JZ,et al.Association between the MLX interacting protein-like,BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels.Sci Rep,2014,4(7):5565.
[49]Seifi M,Ghasemi A,Namipashaki A,et al.Is C771Gpolymorphism of MLX interacting protein-like(MLXIPL)gene a novel genetic risk factor for non-alcoholic fatty liver disease?Cell Mol Biol(Noisy-le-grand),2014,60(3):37-42
[50]Alobeidy BF,Li C,Alzobair AA,et al.The association study between twenty one polymorphisms in seven candidate genes and coronary heart diseases in Chinese Han population.PLoS One,2013,8(6):e66976
[51]Kaadige MR,Looper RE,Kamalanaadhan S,et al.Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity.Proc Natl Acad Sci USA,2009,106(35):14878-14883
[52]刘红茹,范夏婧,崔艳芬.谷氨酰胺在肿瘤中异常代谢的研究进展.肿瘤,2017,37(11):1224-1230
[53]Sanchez EL,Carroll PA,Thalhofer AB,et al.Latent KSHV infected endothelial cells are glutamine addicted and require glutaminolysis for survival.PLOS Pathogens,2015,11(7):e1005052
[54]Qu X,Sun J,Zhang Y,et al.c-Myc-driven glycolysis via TXNIP suppression is dependent on glutaminase-MondoA axis in prostate cancer.Biochem Biophys Res Commun,2018,504(2):415-421
[55]耿西林,张煜,李晖,等.碳水化合物反应元件结合蛋白在肝癌中表达与作用.中国普通外科杂志,2016,25(7):1005-1010
[56]陈寒蓓,林宁,苏青.糖化终末产物对人结肠癌HCT116细胞中ChREBP表达的影响.同济大学学报(医学版),2018,39(3):30-35
[57]Wang H,Dolezal JM,Kulkarni S,et al.Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice.JBiol Chem,2018,293(38):14740-14757
[58]Kaadige MR,Yang J,Wilde BR,et al.MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.Mol Cell Biol,2015,35(1):101-110
[59]Elgort MG,O'Shea JM,Jiang Y,et al.Transcriptional and translational downregulation of thioredoxin interacting protein is required for metabolic reprogramming during G(1).Genes Cancer,2010,1(9):893-907
[2]Kishton RJ,Rathmell JC.Novel therapeutic targets of tumor metabolism.Cancer J,2015,21(2):62-69
[3]Ma L,Tsatsos NG,Towle HC.Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.JBiol Chem,2005,280(12):12019-12027
[4]Stoeckman AK,Ma L,Towle HC.Mlx is the functional heteromeric partner of the carbohydrate response elementbinding protein in glucose regulation of lipogenic enzyme genes.J Biol Chem,2004,279(15):15662-15669
[5]Havula E,Hietakangas V.Glucose sensing by ChREBP/MondoA-Mlx transcription factors.Semin.Cell Dev Biol,2012,23(6):640-647
[6]Richards P,Ourabah S,Montagne J,et al.MondoA/ChREBP:The usual suspects of transcriptional glucose sensing;Implication in pathophysiology.Metab Clin Exp,2017,70(1):133-151
[7]Nath A,Chan C.Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers.Sci Rep,2016,6(1):18669
[8]Dang CV.Web of the extended Myc network captures metabolism for tumorigenesis.Cancer Cell,2015,27(2):160-162
[9]Singh P,Irwin DM.Contrasting patterns in the evolution of vertebrate MLX interacting protein(MLXIP)and MLX interacting protein-like(MLXIPL)genes.PLoSOne,2016,11(2):e149682
[10]Ge Q,Nakagawa T,Wynn RM,et al.Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein(ChREBP).JBiol Chem,2011,286(32):28119-28127
[11]Yu FX,Luo Y.Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules.PLoSOne,2009,4(12):e8397
[12]崔潞晴,黄德玉,陆启荣,等.转录因子MondoA在糖代谢中的研究进展.动物医学进展,2018,39(3):97-102
[13]Davies MN,O'Callaghan BL,Towle HC.Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.J Biol Chem,2008,283(35):24029-24038
[14]Sans CL,Satterwhite DJ,Stoltzman CA,et al.MondoA-Mlx heterodimers are candidate sensors of cellular energy status:mitochondrial localization and direct regulation of glycolysis.Mol Cell Biol,2006,26(13):4863-4871
[15]Ma L,Sham YY,Walters KJ,et al.A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription.Nucleic Acids Res,2007,35(1):35-44
[16]Kabashima T,Kawaguchi T,Wadzinski BE,et al.Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.Proc Natl Acad Sci USA,2003,100(9):5107-5112
[17]Dentin R,Tomas-Cobos L,Foufelle F,et al.Glucose 6-phosphate,rather than xylulose 5-phosphate,is required for the activation of ChREBP in response to glucose in the liver.J Hepatol,2012,56(1):199-209
[18]Li MV,Chen W,Harmancey RN,et al.Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein(ChREBP).Biochem Biophys Res Commun,2010,395(3):395-400
[19]Stoltzman CA,Kaadige MR,Peterson CW,et al.MondoAsenses non-glucose sugars:regulation of thioredoxininteracting protein(TXNIP)and the hexose transport curb.J Biol Chem,2011,286(44):38027-38034
[20]Petrie JL,Al-Oanzi ZH,Arden C,et al.Glucose induces protein targeting to glycogen in hepatocytes by fructose2,6-bisphosphate-mediated recruitment of MondoA to the promoter.Mol Cell Biol,2013,33(4):725-738
[21]麦青,张雁.肿瘤代谢异质性的研究进展.中国细胞生物学学报,2017,40(6):786-795
[22]周鑫,王义平,徐莺莺,等.细胞代谢异常与肿瘤发生发展.生命的化学,2016,36(6):739-744
[23]Warburg O.On the origin of cancer cells.Science,1956,123(3191):309-314
[24]Hensley CT,Faubert B,Yuan Q,et al.Metabolic heterogeneity in human lung tumors.Cell,2016,164(4):681-694
[25]Hakimi AA,Reznik E,Lee CH,et al.An integrated metabolic atlas of clear cell renal cell carcinoma.Cancer Cell,2016,29(1):104-116
[26]Currie E,Schulze A,Zechner R,et al.Cellular fatty acid metabolism and cancer.Cell Metab,2013,18(2):153-161
[27]Stoltzman CA,Peterson CW,Breen KT,et al.Glucose sensing by MondoA:Mlx complexes:a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.Proc Natl Acad Sci USA,2008,105(19):6912-6917
[28]莫与琳,杨亚军,崔燎.TXNIP介导的氧化应激在疾病中的作用机制.中国药理学通报,2018,34(1):16-19
[29]Yu FX,Chai TF,He H,et al.Thioredoxin-interacting protein(Txnip)gene expression:sensing oxidative phosphorylation status and glycolytic rate.J Biol Chem,2010,285(33):25822-25830
[30]Wilde BR,Ayer DE.Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis.Br J Cancer,2015,113(11):1529-1533
[31]Shen L,O'Shea J M,Kaadige M R,et al.Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.Proc Natl Acad Sci USA,2015,112(17):5425-5430
[32]Parmenter TJ,Kleinschmidt M,Kinross KM,et al.Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis.Cancer Discov,2014,4(4):423-433
[33]Carroll PA,Diolaiti D,McFerrin L,et al.Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.Cancer Cell,2015,27(2):271-285
[34]Iizuka K.The transcription factor carbohydrate-response element-binding protein(ChREBP):A possible link between metabolic disease and cancer.Biochim Biophys Acta Mol Basis Dis,2017,1863(2):474-485
[35]Tong X,Zhao F,Mancuso A,et al.The glucose-responsive transcription factor ChREBP contributes to glucosedependent anabolic synthesis and cell proliferation.Proc Natl Acad Sci USA,2009,106(51):21660-21665
[36]Kaushik AK,Shojaie A,Panzitt K,et al.Inhibition of the hexosamine biosynthetic pathway promotes castrationresistant prostate cancer.Nat Commun,2016,7(5):11612
[37]Airley RE,McHugh P,Evans AR,et al.Role of carbohydrate response element-binding protein(ChREBP)in generating an aerobic metabolic phenotype and in breast cancer progression.Br J Cancer,2014,110(3):715-723
[38]Wang XL,Wen XF,Li RB,et al.Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer.Tumour Biol,2014,35(8):8143-8148
[39]Zeng H,Gu H,Chen C,et al.ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.Oncotarget,2016,7(25):38347-38358
[40]Jiang L,Xiao L,Sugiura H,et al.Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition.Oncogene,2015,34(30):3908-3916
[41]Jeong Y S,Kim D,Lee Y S,et al.Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.PLoS One,2011,6(7):e22544
[42]李博.肿瘤糖代谢紊乱的研究进展和探索.中山大学学报(医学科学版),2017,38(2):222-228
[43]萨日娜,武会娟.脂代谢通路及脂代谢异常在癌症中的研究现状.肿瘤防治研究,2016,43(10):907-912
[44]张国华,戴洪伟,卢建雄.转录因子ChREBP在葡萄糖诱导生脂中的作用.中国生物化学与分子生物学报,2016,32(3):245-252
[45]张明捷,陈寒蓓.转录因子碳水化合物反应元件结合蛋白研究进展.中国疗养医学,2018,27(8):800-805
[46]Peterson CW,Ayer DE.An extended Myc network contributes to glucose homeostasis in cancer and diabetes.Front Biosci(Landmark Ed),2011,16(6):2206-2223
[47]Ghasemi A,Aghajani H,Fallah S,et al.C771G(His-241Gln)polymorphism of MLXIPL gene,TG levels and coronary artery disease:a case control study.Anatol JCardiol,2015,15(1):8-12
[48]Aung LH,Yin RX,Wu JZ,et al.Association between the MLX interacting protein-like,BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels.Sci Rep,2014,4(7):5565.
[49]Seifi M,Ghasemi A,Namipashaki A,et al.Is C771Gpolymorphism of MLX interacting protein-like(MLXIPL)gene a novel genetic risk factor for non-alcoholic fatty liver disease?Cell Mol Biol(Noisy-le-grand),2014,60(3):37-42
[50]Alobeidy BF,Li C,Alzobair AA,et al.The association study between twenty one polymorphisms in seven candidate genes and coronary heart diseases in Chinese Han population.PLoS One,2013,8(6):e66976
[51]Kaadige MR,Looper RE,Kamalanaadhan S,et al.Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity.Proc Natl Acad Sci USA,2009,106(35):14878-14883
[52]刘红茹,范夏婧,崔艳芬.谷氨酰胺在肿瘤中异常代谢的研究进展.肿瘤,2017,37(11):1224-1230
[53]Sanchez EL,Carroll PA,Thalhofer AB,et al.Latent KSHV infected endothelial cells are glutamine addicted and require glutaminolysis for survival.PLOS Pathogens,2015,11(7):e1005052
[54]Qu X,Sun J,Zhang Y,et al.c-Myc-driven glycolysis via TXNIP suppression is dependent on glutaminase-MondoA axis in prostate cancer.Biochem Biophys Res Commun,2018,504(2):415-421
[55]耿西林,张煜,李晖,等.碳水化合物反应元件结合蛋白在肝癌中表达与作用.中国普通外科杂志,2016,25(7):1005-1010
[56]陈寒蓓,林宁,苏青.糖化终末产物对人结肠癌HCT116细胞中ChREBP表达的影响.同济大学学报(医学版),2018,39(3):30-35
[57]Wang H,Dolezal JM,Kulkarni S,et al.Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice.JBiol Chem,2018,293(38):14740-14757
[58]Kaadige MR,Yang J,Wilde BR,et al.MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.Mol Cell Biol,2015,35(1):101-110
[59]Elgort MG,O'Shea JM,Jiang Y,et al.Transcriptional and translational downregulation of thioredoxin interacting protein is required for metabolic reprogramming during G(1).Genes Cancer,2010,1(9):893-907