老年冠心病急性发作期病人血清同型半胱氨酸与LPL基因多态性相关分析
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摘要
目的探讨老年冠心病急性发作期病人血清同型半胱氨酸(Hcy)与脂蛋白脂肪酶(LPL)基因多态性的关系。方法选取2015年1月—2016年3月在我院治疗的冠心病病人84例(观察组),同时选取健康者53名作为对照组,检测两组LPL基因位点rs11570892多态性以及血清Hcy、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平。结果观察组Hcy和TG分别为(20.10±6.43)μmol/L和(1.81±0.93)mmol/L,明显高于对照组,而HDL-C为(0.81±0.21)mmol/L,明显低于对照组,差异有统计学意义(P<0.05);观察组和对照组LPL rs11570892位点基因型及等位基因分布比较差异无统计学意义(P>0.05);观察组GG型病人TG为(2.13±0.41)mmol/L,明显高于AA和GA型病人,而HDL-C为(0.71±0.18)mmol/L,明显高于AA和GA型病人,差异比较有统计学意义(P<0.05);不同基因型血清Hcy、TC和LDL-C比较差异无统计学意义(P>0.05)。结论 LPL基因多态性与老年冠心病急性发作期血清Hcy无关,其可能与病人血脂水平有关。
Objective To investigate the correlation between serum homocysteine(Hcy)and Lipoprotein lipase(LPL)gene polymorphism in elderly patients with acute coronary heart disease.Methods Eighty-four patients with coronary heart disease in our hospital from January 2015 to March 2016 were as observation group.Fifty-three healthy individuals were as controls.The polymorphism of LPL gene locus rs11570892 and serum Hcy,total cholesterol(TC),triglyceride(TG),low density lipoproteincholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)levels were detected.Results The levels of Hcy and TG were(20.10±6.43)mmol/L and(1.81±0.93)mmol/L in observation group,which was significantly higher than that in control group(P <0.05).HDLC level was(0.81±0.21)mmol/L,which was significantly lower than that in control group(P <0.05).There was no difference in LPL rs11570892 locus genotype and allele between two groups(P >0.05).TG level in observation group with GG patients was significantly higher than that in patients with AA and GA(P <0.05).HDL-C level in observation group with GG patients was significantly higher than that in patients with AA and GA(P <0.05).There was no difference in serum Hcy,TC and LDL-C among patients with different genotypes(P >0.05).Conclusion LPL gene polymorphism was not associated with serum Hcy in elderly patients with acute coronary heart disease,which may be related to the serum lipid level.
Objective To investigate the correlation between serum homocysteine(Hcy)and Lipoprotein lipase(LPL)gene polymorphism in elderly patients with acute coronary heart disease.Methods Eighty-four patients with coronary heart disease in our hospital from January 2015 to March 2016 were as observation group.Fifty-three healthy individuals were as controls.The polymorphism of LPL gene locus rs11570892 and serum Hcy,total cholesterol(TC),triglyceride(TG),low density lipoproteincholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)levels were detected.Results The levels of Hcy and TG were(20.10±6.43)mmol/L and(1.81±0.93)mmol/L in observation group,which was significantly higher than that in control group(P <0.05).HDLC level was(0.81±0.21)mmol/L,which was significantly lower than that in control group(P <0.05).There was no difference in LPL rs11570892 locus genotype and allele between two groups(P >0.05).TG level in observation group with GG patients was significantly higher than that in patients with AA and GA(P <0.05).HDL-C level in observation group with GG patients was significantly higher than that in patients with AA and GA(P <0.05).There was no difference in serum Hcy,TC and LDL-C among patients with different genotypes(P >0.05).Conclusion LPL gene polymorphism was not associated with serum Hcy in elderly patients with acute coronary heart disease,which may be related to the serum lipid level.
引文
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[15]Zvyagina MV,Mal GS,Bushueva OY,et al.Estmating the effectiveness of hypolipidemic therapy with rosuvastatin in paients with coronary heart disesse depnding on the genotype of lipoprotein lipase[J].Eksperimentalnaia I Klinicheskaia Farmakologiia,2016,25(5):102-104.
[2]邓远琼,张志娟,李宏翔,等.血管内皮功能及同型半胱氨酸对冠心病的预测价值研究[J].中国全科医学,2013,42(37):3672-3675.
[3]康健,赵兴山,丁幼楠.同型半胱氨酸对老年女性冠心病患者的影响[J].重庆医学,2014,26(35):4820-4822.
[4]李汉颖.血清同型半胱氨酸与LPL基因多态性在冠心病风险中的相关分析[J].医学理论与实践,2015,22(12):1588-1589.
[5]李研研,王洪云,马龙乐,等.LPL基因突变与高甘油三酯血症相关性研究进展[J].中华临床医师杂志(电子版),2014,25(2):331-336.
[6]Kolovou GD,Kolovou V,Panagiotakos DB,et al.Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index[J].Hormones(Athens),2015,14(3):376-382.
[7]李杨,沈洁,申亚丽,等.高同型半胱氨酸血症在冠心病患者中的意义[J].中国医科大学学报,2014,26(10):885-888.
[8]于哲新,李虹伟,顾复生,等.北京市大兴区西红门社区居民冠心病危险因素变化分析[J].中国全科医学,2015,42(28):3452-3455.
[9]张双元,张艳菊,李志斐.冠心病患者血清Hcy、GGT水平变化及其意义[J].山东医药,2015,42(26):64-65.
[10]章火祥,沈月爽,陈建明,等.外周血同型半胱氨酸和游离脂肪酸水平与冠心病的关系[J].中国动脉硬化杂志,2014,25(8):831-834.
[11]杨驭媒,翟亚茹,刘小琦,等.血清同型半胱氨酸水平及CPS1基因多态性与冠心病的相关性分析[J].中国分子心脏病学杂志,2014,22(5):1098-1102.
[12]王佳琪,王阳,徐海明,等.老年冠心病患者同型半胱氨酸水平与血脂相关性[J].中国老年学杂志,2015,25(5):1284-1286.
[13]Hamid M,Ahmed S,Salah A,et al.Association of lipoprotein lipase gene with coronary heart disease in Sudanese population[J].Journal of Epidemiology&Global Health,2015,26(5):90-92.
[14]Jelassi A,Jguirim I,Slimani A,et al.Association between variants of lipoprotein lipase and coronary heart disease in a Tunisian population[J].Pathol Biol(Paris),2012,60(3):180-184.
[15]Zvyagina MV,Mal GS,Bushueva OY,et al.Estmating the effectiveness of hypolipidemic therapy with rosuvastatin in paients with coronary heart disesse depnding on the genotype of lipoprotein lipase[J].Eksperimentalnaia I Klinicheskaia Farmakologiia,2016,25(5):102-104.