不同剂量阿托伐他汀治疗急性脑梗死患者的临床疗效比较
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摘要
目的探讨不同剂量阿托伐他汀治疗急性脑梗死患者的临床疗效。方法选择2016年1月至2018年1月我院收治的100例急性脑梗死患者,随机分为两组各50例。观察组给予20 mg阿托伐他汀治疗,对照组给予10 mg阿托伐他汀治疗。比较两组的炎性因子水平、神经功能、颈动脉斑块面积及内膜中层厚度(IMT),以及复发率。结果治疗后,观察组的IL-6、 MMP-9及hs-CRP水平均显著低于对照组(P <0.05)。治疗后,观察组的神经功能评分为(4.06±2.13)分,显著低于对照组的(7.62±2.11)分(P <0.05)。治疗后,观察组的颈动脉斑块面积及IMT均显著优于对照组(P <0.05)。观察组的复发率为0.00%,显著低于对照组的12.00%(P <0.05)。结论 20 mg阿托伐他汀治疗急性脑梗死患者的效果优于10 mg阿托伐他汀,可有效降低患者的炎性因子水平及复发率,缩小斑块面积,减轻神经功能损伤,促进患者转归。
Objective To explore the clinical efficacy of different doses of atorvastatin for the treatment of patients with acute cerebral infarction. Methods 100 cases of patients with acute cerebral infarction admitted to our hospital from January 2016 to January 2018 were selected and randomly divided into two groups equally. The control group was treated with 10 mg atorvastatin, and the observation group was treated with 20 mg atorvastatin. The levels of inflammatory factors, neurological function, carotid plaque area and intima-media thickness(IMT), and recurrence rate were compared between two groups. Results After treatment, the levels of IL-6, MMP-9 and hs-CRP of observation group were significantly lower than those of control group(P <0.05). After treatment, the score of neurological function of observation group was(4.06 ± 2.13) points, significantly lower than(7.62 ± 2.11) points of control group(P <0.05). After treatment, the carotid plaque area and IMT of observation group were significantly better than those of control group(P <0.05). The recurrence rate of observation group was 0.00%, significantly lower than 12.00% of control group(P <0.05). Conclusions 20 mg atorvastatin has better effect than 10 mg atorvastatin for the treatment of patients with acute cerebral infarction, which can effectively reduce the levels of inflammatory factors and recurrence rate, reduce plaque area, reduce nerve function damage, and promote the outcome of patients.
Objective To explore the clinical efficacy of different doses of atorvastatin for the treatment of patients with acute cerebral infarction. Methods 100 cases of patients with acute cerebral infarction admitted to our hospital from January 2016 to January 2018 were selected and randomly divided into two groups equally. The control group was treated with 10 mg atorvastatin, and the observation group was treated with 20 mg atorvastatin. The levels of inflammatory factors, neurological function, carotid plaque area and intima-media thickness(IMT), and recurrence rate were compared between two groups. Results After treatment, the levels of IL-6, MMP-9 and hs-CRP of observation group were significantly lower than those of control group(P <0.05). After treatment, the score of neurological function of observation group was(4.06 ± 2.13) points, significantly lower than(7.62 ± 2.11) points of control group(P <0.05). After treatment, the carotid plaque area and IMT of observation group were significantly better than those of control group(P <0.05). The recurrence rate of observation group was 0.00%, significantly lower than 12.00% of control group(P <0.05). Conclusions 20 mg atorvastatin has better effect than 10 mg atorvastatin for the treatment of patients with acute cerebral infarction, which can effectively reduce the levels of inflammatory factors and recurrence rate, reduce plaque area, reduce nerve function damage, and promote the outcome of patients.
引文
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[5]南毛球,曹雄彬,宫丽,等.不同剂量阿托伐他汀对老年急性脑梗死患者血清脂联素和趋化素水平的影响[J].中华老年心脑血管病杂志, 2017, 19(2):175-178.
[6]宋昌鹏,王成凯.不同剂量阿托伐他汀对脑梗死患者临床疗效的影响[J].西南国防医药, 2017, 27(2):151-153.
[7]李立,王骐,张娜,等.不同剂量阿托伐他汀钙治疗急性脑梗死的疗效及其相关因素的影响[J].西部医学, 2018, 30(6):839-842, 846.
[2]卫生部疾病控制司.中国脑血管病防治指南[J].中国现代神经疾病杂志, 2007, 7(2):17-18.
[3]周永,林森,赵连东.不同剂量阿托伐他汀对急性脑梗死患者超敏C反应蛋白S100B蛋白水平及神经功能缺损的影响[J].安徽医学, 2015, 36(9):1100-1102.
[4]任蓓,张爱香,沙娟娟,等.不同剂量阿托伐他汀钙对脑梗死患者血清炎症因子及颈动脉斑块的影响[J].药物评价研究, 2017, 40(6):812-815.
[5]南毛球,曹雄彬,宫丽,等.不同剂量阿托伐他汀对老年急性脑梗死患者血清脂联素和趋化素水平的影响[J].中华老年心脑血管病杂志, 2017, 19(2):175-178.
[6]宋昌鹏,王成凯.不同剂量阿托伐他汀对脑梗死患者临床疗效的影响[J].西南国防医药, 2017, 27(2):151-153.
[7]李立,王骐,张娜,等.不同剂量阿托伐他汀钙治疗急性脑梗死的疗效及其相关因素的影响[J].西部医学, 2018, 30(6):839-842, 846.