从肾虚血瘀论治老年血管性痴呆的临床研究进展
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摘要
目的:通过查阅文献,对老年血管性痴呆从肾虚血瘀论治的临床研究进展进行述评。方法:通过检索中国知网、万方数据库和Pub Med中近10年相关文献,对文献中所记载的治疗血管性痴呆的中医药临床研究进行归纳、整理和分析。检索词分别为"中医药、肾虚血瘀、血管性痴呆、临床"和"Traditional Chinese Medicine,kidney deficiency and blood stasis,vascular dementia,clinic",检索式分别为"并"和"and"。结果:共检索到中文文献306篇,英文文献18篇,根据文献筛选标准剔除重复及不规范的文献,引用30篇文献。结论:肾虚血瘀是引起血管性痴呆的重要病机,补肾以益髓,活血以通络,从而可以改善血管性痴呆的认知水平和学习能力,其主要的作用机制与肾虚血瘀有关。
Objective: After review of the literature,to summarize the clinical research progress of traditional Chinese medicine treating vascular dementia by kidney deficiency and blood stasis. Methods: The author searched the literature from CNKI database,Articles database and Pub Med database of the last 10 years,generalizing and analyzing literature about clinical treatment research on vascular dementia by traditional Chinese medicine in recent years. The key words were"Traditional Chinese Medicine,kidney deficiency and blood stasis,vascular dementia,clinic"in Chinese and English. The retrieval type was"and"in Chinese and English. Results: A total of 306 articles in Chinese and 18 articles in English were obtained and 30 articles were included according to the literature selection criteria,removing repeated and non- standard articles. Conclusion: Kidney deficiency and blood stasisis are the important pathogenesis of causing vascular dementia,Bushen Yisui,Huoxue Tongluo,thus improving the level of recognize and learning ability on vascular dementia,the main mechanism related to the kidney deficiency and blood stasis.
Objective: After review of the literature,to summarize the clinical research progress of traditional Chinese medicine treating vascular dementia by kidney deficiency and blood stasis. Methods: The author searched the literature from CNKI database,Articles database and Pub Med database of the last 10 years,generalizing and analyzing literature about clinical treatment research on vascular dementia by traditional Chinese medicine in recent years. The key words were"Traditional Chinese Medicine,kidney deficiency and blood stasis,vascular dementia,clinic"in Chinese and English. The retrieval type was"and"in Chinese and English. Results: A total of 306 articles in Chinese and 18 articles in English were obtained and 30 articles were included according to the literature selection criteria,removing repeated and non- standard articles. Conclusion: Kidney deficiency and blood stasisis are the important pathogenesis of causing vascular dementia,Bushen Yisui,Huoxue Tongluo,thus improving the level of recognize and learning ability on vascular dementia,the main mechanism related to the kidney deficiency and blood stasis.
引文
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[15]李君,高维娟,路国兵,等.补阳还五汤对血管性痴呆大鼠海马Gh1R1蛋白及mRNA表达的影响[J].中国病理生理杂志,2010,26(5):90-96.
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[19]伍大华,姚婷,蒋军林,等.滋肾活血法治疗血管性痴呆肾阴虚血瘀证的临床研究[J].甘肃中医,2015,13(12):1372-1374.
[20]刘波,李应昆,袁斓.补肾活血化瘀验方治疗血管性痴呆的临床研究[J].成都中医药大学学报,2011,34(1):22-23.
[21]唐小芳.补肾活血方药治疗血管性痴呆疗效观察[J].新中医,2014,46(4):61-63.
[22]杨文文,杨慧艳,陈东晖,等.理气化痰祛瘀法治疗血管性痴呆临床观察[J].辽宁中医药大学学报,2012,14(2):146-147.
[23]于树夔.醒脑益智丸治疗血管性痴呆的临床研究[J].中华中医药杂志,2009,24(6):794-796.
[24]张伯礼,王永炎,陈汝兴,等.健脑益智颗粒治疗血管性痴呆的随机双盲临床研究[J].中国中西医结合杂志,2002,22(8):577-579.
[25]黄琳娜,安军民,苏同生,等.头针治疗血管性痴呆随机对照临床研究[J].上海针灸杂志,2010,29(2):79-82.
[26]楚佳梅,包烨华,邹超.头穴久留针对血管性痴呆病人认知和生活能力及P300的影响[J].针刺研究,2008,33(5):334-338.
[27]李思康,丁定明,刘茜.头针治疗血管性痴呆随机对照研究[J].上海针灸杂志,2012,31(11):806-808.
[28]王磊磊,陈晓朋,姬佳.电项针结合头针治疗血管性痴呆的临床观察[J].针灸临床杂志,2013,29(3):41-42.
[29]周薇,周仲瑜.头针加体针治疗血管性痴呆的临床观察[J].针灸临床杂志,2012,28(6):11-14.
[30]高千仞,陈甦,黄燕苹.头针疗法对脑卒中后轻度血管性痴呆的影响[J].实用中医药杂志,2013,29(11):890-891.
[2]王一洲,刘宇,赵强.中医药治疗血管性痴呆的研究进展[J].四川中医,2013,31(1):144-146.
[3]Brayne C,Stephan BC,Matthews FE.A European perspective on population studies of dementia[J].Alzheimers Dement,2011,7(1):3-9.
[4]Dong MJ,Peng B,Lin XT,et al.The prevalence of dementia in the People's Repu-blic of China:a systematic analysis of 1980-2004studies[J].Age Ageing,2007,36(6):619-624.
[5]张岗,王发渭.血管性痴呆的中医研究新进展[J].时珍国医国药,2010,21(3):769-771.
[6]田金洲,刘中垣.老年痴呆的中医药研究思路[J].中国医药学报,2000,15(5):72-74.
[7]吴力萍,陶连方.补肾益气化瘀胶囊治疗血管性痴呆临床研究[J].医学研究杂志,2009,38(1):100-102.
[8]闰淑荣.老年人体质及用药规律浅识[J].实用中医内科杂志,2006,20(1):97-98.
[9]宋先红,况时祥.脑通汤对血管性痴呆大鼠海马神经元凋亡基因Bcl-2、Bax及Bcl-2/Bax比例变化的影响[J].时珍国医国药,2014,25(11):2567-2570.
[10]张树森,况时祥,肖雁,等.脑通胶囊对血管性痴呆大鼠海马丙二醛、超氧化物歧化酶及突触超微结构的影响[J].时珍国医国药,2012,23(6):1436-1438.
[11]张吉仲,彭成,谢晓芳.益智五海胶囊对血管性痴呆模型大鼠的海马Ach、Ach E及大脑皮层5-HT、NE、DA的影响[J].华西药学杂志,2010,25(5):627-628.
[12]杨春壮,马英,张春军,等.补肾醒脑方对血管性痴呆大鼠学习能力及组织内乙酰胆碱酯酶含量的影响[J].中医研究,2011,24(12):10-12.
[13]李菲,郭蕾,乔之龙.补肾益智汤对老年痴呆模型大鼠治疗作用的实验研究[J].时珍国医国药,2010,21(2):315-317.
[14]杨文明,王时光,鲍远程,等.智脑胶囊对血管性痴呆模型大鼠行为学及脑组织NO、ET、CGRP含量的影响[J].中国实验方剂学杂志,2008,14(1):29-32.
[15]李君,高维娟,路国兵,等.补阳还五汤对血管性痴呆大鼠海马Gh1R1蛋白及mRNA表达的影响[J].中国病理生理杂志,2010,26(5):90-96.
[16]李君,钱涛,高维娟,等.补阳还五汤对血管性痴呆大鼠行为学和海马神经元形态学的影响[J].中西医结合心脑血管病杂志,2010,8(1):69-71.
[17]刘玲玲,张博,吕素君.肾虚血瘀在血管性痴呆中的地位及意义[J].河北中医,2006,28(1):77-78.
[18]郝卫平.补阳还五汤加味治疗血管性痴呆38例疗效观察[J].中国实用医药,2009,14(4):164-165.
[19]伍大华,姚婷,蒋军林,等.滋肾活血法治疗血管性痴呆肾阴虚血瘀证的临床研究[J].甘肃中医,2015,13(12):1372-1374.
[20]刘波,李应昆,袁斓.补肾活血化瘀验方治疗血管性痴呆的临床研究[J].成都中医药大学学报,2011,34(1):22-23.
[21]唐小芳.补肾活血方药治疗血管性痴呆疗效观察[J].新中医,2014,46(4):61-63.
[22]杨文文,杨慧艳,陈东晖,等.理气化痰祛瘀法治疗血管性痴呆临床观察[J].辽宁中医药大学学报,2012,14(2):146-147.
[23]于树夔.醒脑益智丸治疗血管性痴呆的临床研究[J].中华中医药杂志,2009,24(6):794-796.
[24]张伯礼,王永炎,陈汝兴,等.健脑益智颗粒治疗血管性痴呆的随机双盲临床研究[J].中国中西医结合杂志,2002,22(8):577-579.
[25]黄琳娜,安军民,苏同生,等.头针治疗血管性痴呆随机对照临床研究[J].上海针灸杂志,2010,29(2):79-82.
[26]楚佳梅,包烨华,邹超.头穴久留针对血管性痴呆病人认知和生活能力及P300的影响[J].针刺研究,2008,33(5):334-338.
[27]李思康,丁定明,刘茜.头针治疗血管性痴呆随机对照研究[J].上海针灸杂志,2012,31(11):806-808.
[28]王磊磊,陈晓朋,姬佳.电项针结合头针治疗血管性痴呆的临床观察[J].针灸临床杂志,2013,29(3):41-42.
[29]周薇,周仲瑜.头针加体针治疗血管性痴呆的临床观察[J].针灸临床杂志,2012,28(6):11-14.
[30]高千仞,陈甦,黄燕苹.头针疗法对脑卒中后轻度血管性痴呆的影响[J].实用中医药杂志,2013,29(11):890-891.