血尿酸和脑钠肽水平评估进展性缺血性脑卒中的价值分析
|
摘要
目的探讨血尿酸和脑钠肽水平评估进展性缺血性脑卒中的价值。方法选取该院于2016年10月至2017年10月收治的进展性缺血性脑卒中患者63例作为观察组,根据病情严重程度分为:轻型[美国国立卫生研究院卒中量表(NIHSS)评分<7分]、中型(NIHSS评分7～15分)、重型(NIHSS评分>15分)。另选取该院于2014年1月至2016年12月收治的非进展性缺血性脑卒中患者60例作为对照组。两组患者均于入院后采集空腹外周静脉血3mL,分离血清,采用酶联免疫吸附试验(ELISA法)测定脑钠肽水平,采用尿酸/过氧化物酶偶联法测定血尿酸水平。结果观察组血尿酸和脑钠肽水平明显高于对照组,差异有统计学意义(P<0.05);重型组血尿酸和脑钠肽水平高于轻型组和中型组,且中型组血尿酸和脑钠肽水平高于轻型组,差异均有统计学意义(P<0.05);血尿酸与脑钠肽联合检测的灵敏度和特异度高于血尿酸、脑钠肽单项指标检测,差异有统计学意义(P<0.05)。结论血尿酸和脑钠肽联合检测具有较高的灵敏度和特异度。
Objective To investigate the value of serum uric acid and brain natriuretic peptide in the evaluation of progressive ischemic stroke.Methods Totally 63 cases of progressive ischemic stroke patients in our hospital from October 2016 to October 2017 were selected as the observation group.According to the severity of the disease,the patients were divided into mild group[National Institute of Health Stroke Scale(NIHSS)score<7],medium group(NIHSS score 7-15)and severe(NIHSS score>15).Meanwhile,60 cases of nonprogressive ischemic stroke patients in the hospital from January 2014 and December 2016 were selected as the control group.After admission,3 mL fasting peripheral venous blood was collected in each subject in both groups,and the serum was isolated.Enzyme-linked immunosorbent assay(ELISA)was used to determine the level of brain natriuretic peptide and uric acid/eroxidase coupling method was used to determine the level of serum uric acid.Results The levels of serum uric acid and brain natriuretic peptide were significantly higher than those of the control group(P<0.05).The levels of natriuretic peptide and serum uric acid in severe group were significantly higher than those of mild group and medium group,and the levels of two indicators in medium group were significantly higher than those of mild group(P<0.05).In addition,the sensitivity and specificity of combined detection were significantly higher than the single index detection of serum uric acid and brain natriuretic peptid(P<0.05).Conclusion The combined detection of serum uric acid and brain natriuretic peptide have higher sensitivity and specificity.
Objective To investigate the value of serum uric acid and brain natriuretic peptide in the evaluation of progressive ischemic stroke.Methods Totally 63 cases of progressive ischemic stroke patients in our hospital from October 2016 to October 2017 were selected as the observation group.According to the severity of the disease,the patients were divided into mild group[National Institute of Health Stroke Scale(NIHSS)score<7],medium group(NIHSS score 7-15)and severe(NIHSS score>15).Meanwhile,60 cases of nonprogressive ischemic stroke patients in the hospital from January 2014 and December 2016 were selected as the control group.After admission,3 mL fasting peripheral venous blood was collected in each subject in both groups,and the serum was isolated.Enzyme-linked immunosorbent assay(ELISA)was used to determine the level of brain natriuretic peptide and uric acid/eroxidase coupling method was used to determine the level of serum uric acid.Results The levels of serum uric acid and brain natriuretic peptide were significantly higher than those of the control group(P<0.05).The levels of natriuretic peptide and serum uric acid in severe group were significantly higher than those of mild group and medium group,and the levels of two indicators in medium group were significantly higher than those of mild group(P<0.05).In addition,the sensitivity and specificity of combined detection were significantly higher than the single index detection of serum uric acid and brain natriuretic peptid(P<0.05).Conclusion The combined detection of serum uric acid and brain natriuretic peptide have higher sensitivity and specificity.
引文
[1] YEON J Y,SHIN H J.Nonprogressive unilateral intracranial arteriopathy in children with arterial ischemic stroke[J].J Korean Neurosurg Soc,2015,57(6):401-407.
[2]杜桂香.缺血性进展性脑卒中危险因素临床分析[J].中国实用神经疾病杂志,2015,19(3):11-13.
[3]冯睿龙,朱沂.急性缺血性脑卒中的磁共振影像学研究进展[J].实用医学杂志,2015,31(3):341-343.
[4]丁俊丽,贺婕,李兰,等.进展性缺血性脑卒中的危险因素[J].中国老年学杂志,2015,35(11):3004-3005.
[5]张健芳,蒋亚斌.尿酸对急性缺血性卒中神经保护作用的研究进展[J].广东医学,2016,37(20):3142-3145.
[6]张国华.脑钠肽用于预测缺血性脑卒中功能预后的价值[J].中国老年保健医学,2014,29(6):112-113.
[7]解红,刘学政,刘新桥.进展性缺血性脑卒中的发病机制和危险因素研究进展[J].中西医结合心脑血管病杂志,2016,14(6):612-614.
[8]冯翠玲,闫俊强,白树风.进展性缺血性脑卒中与糖代谢异常的关系[J].医学综述,2016,22(5):925-928.
[9]解红,刘学政,刘新桥.进展性缺血性脑卒中的发病机制和危险因素研究进展[J].中西医结合心脑血管病杂志,2016,14(6):612-614.
[10]康玲,王战英.进展性缺血性脑卒中相关危险因素分析[J].中国实用神经疾病杂志,2015,13(6):80-81.
[11]范宇威,代大伟,吴珊珊,等.缺血性脑卒中二级预防研究进展[J].现代生物医学进展,2015,15(12):2382-2385.
[12]吴智鑫.B型脑钠肽对急性缺血性脑卒中患者TOAST病因学分型的应用进展[J].岭南急诊医学杂志,2012,17(5):399-400.
[13]方麒林,刘团结,丁联斌,等.急性缺血性脑卒中患者血浆脑钠肽水平与神经功能缺失的关系[J].临床内科杂志,2012,29(10):692-695.
[14]吉章阁.血清尿酸浓度与缺血性脑卒中关系的研究进展[J].医学综述,2013,19(4):617-621.
[15]唐立鸿,康劲,薛玉梅.高尿酸血症与缺血性脑卒中的相关研究进展[J].中华老年心脑血管病杂志,2014,15(8):893-894.
[2]杜桂香.缺血性进展性脑卒中危险因素临床分析[J].中国实用神经疾病杂志,2015,19(3):11-13.
[3]冯睿龙,朱沂.急性缺血性脑卒中的磁共振影像学研究进展[J].实用医学杂志,2015,31(3):341-343.
[4]丁俊丽,贺婕,李兰,等.进展性缺血性脑卒中的危险因素[J].中国老年学杂志,2015,35(11):3004-3005.
[5]张健芳,蒋亚斌.尿酸对急性缺血性卒中神经保护作用的研究进展[J].广东医学,2016,37(20):3142-3145.
[6]张国华.脑钠肽用于预测缺血性脑卒中功能预后的价值[J].中国老年保健医学,2014,29(6):112-113.
[7]解红,刘学政,刘新桥.进展性缺血性脑卒中的发病机制和危险因素研究进展[J].中西医结合心脑血管病杂志,2016,14(6):612-614.
[8]冯翠玲,闫俊强,白树风.进展性缺血性脑卒中与糖代谢异常的关系[J].医学综述,2016,22(5):925-928.
[9]解红,刘学政,刘新桥.进展性缺血性脑卒中的发病机制和危险因素研究进展[J].中西医结合心脑血管病杂志,2016,14(6):612-614.
[10]康玲,王战英.进展性缺血性脑卒中相关危险因素分析[J].中国实用神经疾病杂志,2015,13(6):80-81.
[11]范宇威,代大伟,吴珊珊,等.缺血性脑卒中二级预防研究进展[J].现代生物医学进展,2015,15(12):2382-2385.
[12]吴智鑫.B型脑钠肽对急性缺血性脑卒中患者TOAST病因学分型的应用进展[J].岭南急诊医学杂志,2012,17(5):399-400.
[13]方麒林,刘团结,丁联斌,等.急性缺血性脑卒中患者血浆脑钠肽水平与神经功能缺失的关系[J].临床内科杂志,2012,29(10):692-695.
[14]吉章阁.血清尿酸浓度与缺血性脑卒中关系的研究进展[J].医学综述,2013,19(4):617-621.
[15]唐立鸿,康劲,薛玉梅.高尿酸血症与缺血性脑卒中的相关研究进展[J].中华老年心脑血管病杂志,2014,15(8):893-894.