功能化纳米粒在脑靶向递药中应用的研究进展
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摘要
血脑屏障的存在,导致药物不能有效到达靶部位发挥作用,极大地影响神经系统药物的发展和进步。纳米技术已被证明是用于脑靶向治疗的一种有效工具,尤其在脑肿瘤和神经退行性疾病中应用甚广。功能化纳米粒通过表面修饰等提高药物的顺应性,在药物原来的治疗基础上,达到更加精准的靶向性,高效率在靶部位聚集,起到治疗作用。本文主要综述功能化纳米粒及其功能化策略,总结了影响功能化纳米粒脑靶向运输的因素,同时对功能化的纳米粒在脑部疾病治疗中的优势和应用进行阐述,为其相关研究提供参考。
The existence of the blood-brain barrier results in the drug failing to reach the target site effectively and exerting a great influence on the development and progress of the nervous system drug.Nanotechnology has been proven to be an effective tool for brain-targeted therapy,especially in brain tumors and neurodegenerative diseases. The functionalized nanoparticles improve drug compliance through surface modification and the like,and on the basis of the original treatment of the drug,achieve more precise targeting and high efficiency of aggregation at the target site and play a therapeutic role.This paper reviewed the functional nanoparticles and their functionalization strategies,as well as the advantage and application in diagnosis and treatment of brain diseases.This review provided a reference for the study of the treatment of brain disease.
The existence of the blood-brain barrier results in the drug failing to reach the target site effectively and exerting a great influence on the development and progress of the nervous system drug.Nanotechnology has been proven to be an effective tool for brain-targeted therapy,especially in brain tumors and neurodegenerative diseases. The functionalized nanoparticles improve drug compliance through surface modification and the like,and on the basis of the original treatment of the drug,achieve more precise targeting and high efficiency of aggregation at the target site and play a therapeutic role.This paper reviewed the functional nanoparticles and their functionalization strategies,as well as the advantage and application in diagnosis and treatment of brain diseases.This review provided a reference for the study of the treatment of brain disease.
引文
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[12]李学娟,张雪梅,王蒙,等.肿瘤穿透肽修饰的载姜黄素PLGA纳米粒的制备及肿瘤靶向性评价[J].中国新药杂志,2016,25(6):692-698.
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[18]徐雄波,潘育方,黄志军,等.鼻腔给药尼莫地平纳米乳的制备及脑组织靶向性初步评价[J].中国药学杂志,2012,47(8):594-597.
[2]王立,梁爽,吕江维,等.从纳米给药系统角度探讨阿尔茨海默病的治疗策略[J].药学研究,2017,26(5):287-291.
[3]刘洋,蒋晨.纳米药物递释系统的脑靶向研究进展[J].药学学报,2013,48(10):1532-1543.
[4]张瑞华,李丽琴,王陈,等.石杉碱甲聚乳酸-乙醇酸纳米粒的制备、表征及其小鼠活体成像脑靶向分布[J].国际药学研究杂志,2014,41(2):221-226.
[5] GAO H,QIAN J,CAO S,et al.Precise gliomatargeting of and penetration by aptamer and peptide dual functioned nanoparticles[J]. Biomaterials,2012,33(20):5115-5123.
[6]肖衍宇,陈曦,邹浪,等.乳铁蛋白修饰纳米脂质载体的制备及其脑靶向性评价[J].中国药学杂志,2013,48(20):1755-1760.
[7]李天傲,许东航,高建青.无机纳米粒克服肿瘤多药耐药的研究进展[J].中国药学杂志,2016,51(16):1360-1363.
[8]李伟男,孙佳琳,管庆霞,等.逆转肿瘤多药耐药性的普朗尼克靶向药物传递系统[J].中国药学杂志,2016,51(15):1270-1273.
[9] XUEQIN W,HUIRU Z,HONGJUAN J,et al.Highly Efficient Labeling of Human Lung Cancer Cells Using Cationic Poly-l-lysine-Assisted Magnetic Iron Oxide Nanoparticles[J]. Nano-Micro Lett,2015,7(4):374-384.
[10]王倩,王康,梁欢,等.用于疫苗输送的功能化磷酸钙纳米载体的制备[J].中国科学,2016,46(9):891-899.
[11]张彦军,刘秀辉,卢娟娟,等.基于聚酰胺-胺功能化碳纳米管负载钯纳米粒子的过氧化氢传感器[J].分析化学,2016,44(9):1402-1409.
[12]李学娟,张雪梅,王蒙,等.肿瘤穿透肽修饰的载姜黄素PLGA纳米粒的制备及肿瘤靶向性评价[J].中国新药杂志,2016,25(6):692-698.
[13]黄元,陶言,李瑞,等.中枢神经系统药物脑部递送体内评价方法[J].中国新药杂志,2016,25(9):1013-1017.
[14] MARIA J G,CARLOS F,SUSANA M,et al. Tailoring Lipid and Polymeric Nanoparticles as siRNA Carriers towards the Blood-Brain Barrier-from Targeting to Safe Administration[J].J Neuroimmune Pharm,2017,12(1):107-119.
[15] MALKA S,ANAT S,KOBY B,et al.The effect of nanoparticle size on the probability to cross the blood-brain barrier:an in-vitro endothelial cell model[J]. J Nanobiotech,2015,13(1):19-25.
[16] LOCKMAN P,KOZIARA J,MUMPER R,et al.Nanoparticle surface charges alter blood-brain barrier integrity and permeability[J].J Drug Target,2004,12(9-10):635-641.
[17] WANG D,GAO Y,YUN L.Advances on brain-targetednasal delivery system[J].Chin New Drug J,2005,14(2):135-140.
[18]徐雄波,潘育方,黄志军,等.鼻腔给药尼莫地平纳米乳的制备及脑组织靶向性初步评价[J].中国药学杂志,2012,47(8):594-597.