自拟培土固本方治疗脾肾两虚型CGN的临床分析
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摘要
目的探讨自拟培土固本方治疗脾肾两虚型慢性肾小球肾炎(chronic glomerulonephritis,CGN)的临床疗效,为临床用药提供参考。方法选取符合诊断标准的100例CGN患者,随机分为治疗组和对照组,各50例。对照组接受西药对症处理,观察组在对照组基础上加以服用自拟培土固本方进行临床疗效对比分析。结果治疗6个月后,治疗组临床显效18例,有效25例,无效7例,总有效率为86. 00%;对照组显效15例,有效22例,无效13例,总有效率74. 00%,两组比较存在显著性差异(P <0. 05)。结论自拟培土固本方治疗脾肾两虚型CGN疗效显著。
Objective: To explore the clinical efficacy of self-made Peitou Guben Prescription in the treatment of chronic glomerulonephritis( CGN) with deficiency of both spleen and kidney,so as to provide reference for clinical medication. Method: 100 cases of CGN patients who met the diagnostic criteria were randomly divided into treatment group and control group,50 cases each. The control group received symptomatic treatment of Western medicine,while the observation group took self-made Peitu Guben Prescription on the basis of the control group for comparative analysis of clinical efficacy. Result: After 6 months of treatment,18 cases were clinically effective in the treatment group,25 cases were effective,7 cases were ineffective,and the total effective rate was 86. 00%. In the control group,15 cases were markedly effective,22 cases were effective,13 cases were ineffective,and the total effective rate was 74. 00%. There was a significant difference between the two groups( P < 0. 05). Conclusion: The self-made Peitou Guben Formula has a significant effect on CGN with both spleen and kidney deficiency.
Objective: To explore the clinical efficacy of self-made Peitou Guben Prescription in the treatment of chronic glomerulonephritis( CGN) with deficiency of both spleen and kidney,so as to provide reference for clinical medication. Method: 100 cases of CGN patients who met the diagnostic criteria were randomly divided into treatment group and control group,50 cases each. The control group received symptomatic treatment of Western medicine,while the observation group took self-made Peitu Guben Prescription on the basis of the control group for comparative analysis of clinical efficacy. Result: After 6 months of treatment,18 cases were clinically effective in the treatment group,25 cases were effective,7 cases were ineffective,and the total effective rate was 86. 00%. In the control group,15 cases were markedly effective,22 cases were effective,13 cases were ineffective,and the total effective rate was 74. 00%. There was a significant difference between the two groups( P < 0. 05). Conclusion: The self-made Peitou Guben Formula has a significant effect on CGN with both spleen and kidney deficiency.
引文
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[8]周英武,彭桂英,葛东宇,等.人参皂苷Rg1对BALB/c小鼠免疫调节作用的实验研究[J].中华中医药志,2011,26(5):1232-1234.
[9]王志江,魏国栋,马思缇.地黄多糖的化学和药理作用研究进展[J].中国实验方剂学杂志,2015,21(16):231-235.
[2]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:158-159.
[3]叶任高,李幼姬,刘冠贤.肾脏病学[M]. 2版.北京:人民卫生出版社,2007:189-190.
[4]刘少军,顾勇,蒋殷睿.黄芪对慢性肾炎大鼠肾脏水通道蛋白的影响[J].中国中西医结合肾脏病杂志,2004,5(11):627-630.
[5]赵爱青,马存根,赵森.丹参注射液对单侧输尿管梗大鼠肾脏的保护[J].山西医药杂志,2007,36(9):785-787.
[6]梁学清,李丹丹,黄忠威.茯苓研究进展[J].河南科技大学学报,2012,30(2):154-156.
[7]段启,许冬谨,刘传祥.白术的研究进展[J].中草药,2014,10(5):13-16.
[8]周英武,彭桂英,葛东宇,等.人参皂苷Rg1对BALB/c小鼠免疫调节作用的实验研究[J].中华中医药志,2011,26(5):1232-1234.
[9]王志江,魏国栋,马思缇.地黄多糖的化学和药理作用研究进展[J].中国实验方剂学杂志,2015,21(16):231-235.