健脾利湿清热解毒汤联合西药治疗糜烂型口腔扁平苔藓(脾虚湿盛)随机平行对照研究
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摘要
[目的]观察健脾利湿清热解毒汤联合西药治疗糜烂型口腔扁平苔藓(脾虚湿盛)疗效。[方法]使用随机平行对照方法,将76例门诊患者按就诊顺序号抽签方法随机分为两组。对照组38例,强的松15mg/次,3次/d;维生素B1,10mg/次,3次/d;维甲酸软膏,局部涂擦患处。治疗组38例健脾利湿清热解毒汤(党参、茯苓、薏苡仁、白及、厚朴、车前子、蒲公英各10g,黄芪20g,甘草3g),水煎300mL,早晚饭后30min服用;西药治疗同对照组。连续治疗1个月为1疗程。观测临床表现、中医证候、口腔黏膜白色损害、不良反应。治疗1疗程(1个月),判定疗效。随访1年,观测复发率。[结果]治疗组痊愈25例,显效10例,无效3例,总有效率92.10%;对照组痊愈17例,显效11例,无效10例,总有效率73.68%;治疗组疗效优于对照组(P<0.05)。中医证候两组均有改善,治疗组改善优于对照组(P<0.01)。随访1年,复发率两组无明显差异(P>0.05)。[结论]健脾利湿清热解毒汤联合西药治疗糜烂型口腔扁平苔藓(脾虚湿盛)疗效满意,无严重不良反应,值得推广。
[Objective] To observe the clinical efficacy of the treatment of spleen deficiency dampness exuberancy erosive oral lichen planus with traditional Chinese prescription. [Method] 76 patients with spleen deficiency dampness exuberancy erosive oral lichen planus were observed and randomly divided into two groups. The patients in control group(38 cases) were treated with tretinoin ointment and vitamin B_1; The patients in therapy group(38 cases) were used traditional Chinese prescription additional to western routine therapy. The curative effectiveness was assessed after one month treatment. The recurrence rate was assessed after one year. [Result] The effective rate in therapy group is 89.5%; the effective rate in control group is 73.7%. The effective rate in therapy group increased significantly compared with the control group(P<0.01). For the syndrome of traditional Chinese medicine, the patients in two groups both improved, but the patients in therapy group improved significantly compared with the control group(P<0.01). And the recurrence rate shows no significant differences between two groups(P>0.05). [Conclusion] Traditional Chinese Prescription treatment for spleen deficiency dampness exuberancy erosive oral lichen planus shows effective in treatment.
[Objective] To observe the clinical efficacy of the treatment of spleen deficiency dampness exuberancy erosive oral lichen planus with traditional Chinese prescription. [Method] 76 patients with spleen deficiency dampness exuberancy erosive oral lichen planus were observed and randomly divided into two groups. The patients in control group(38 cases) were treated with tretinoin ointment and vitamin B_1; The patients in therapy group(38 cases) were used traditional Chinese prescription additional to western routine therapy. The curative effectiveness was assessed after one month treatment. The recurrence rate was assessed after one year. [Result] The effective rate in therapy group is 89.5%; the effective rate in control group is 73.7%. The effective rate in therapy group increased significantly compared with the control group(P<0.01). For the syndrome of traditional Chinese medicine, the patients in two groups both improved, but the patients in therapy group improved significantly compared with the control group(P<0.01). And the recurrence rate shows no significant differences between two groups(P>0.05). [Conclusion] Traditional Chinese Prescription treatment for spleen deficiency dampness exuberancy erosive oral lichen planus shows effective in treatment.
引文
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[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2015-02-01].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]中华口腔医学会口腔黏膜病专业委员会.口腔扁平苔藓诊疗指南(试行)[J].中华口腔医学杂志,2012,47(7):399-401.
[4]熊大经.实用中医耳鼻喉口齿科学[M].上海:上海科技出版社,2001:442-443.
[5]谢冰,熊春蓉,周红梅.口腔扁平苔藓疗效评价体系浅析[J].临床口腔医学杂志,2011,27(5):317-318.
[6]孙玉亮,赵今.口腔扁平苔藓治疗研究的循证医学评价[J].口腔医学研究,2009,25(3):383-385.
[7]陈谦明.口腔黏膜病学[M].4版.北京:人民卫生出版社,2017:103-110.
[8]刘春玲,陈懿德,王婕,等.扁平苔藓外周血T细胞及亚群的研究[J].中国皮肤性病学杂志,2008,10(6):330-331.
[9]李秉琦,周红梅.口腔扁平苔藓的治疗方法及方案[J].临床口腔医学杂志,1994,10(3):186-188.
[10]周刚,樊明文.口腔扁平苔藓的临床治疗[J].口腔医学研究,2004,20(1):99-100.
[11]郑云鹏,顾恒.糖皮质激素与骨质疏松[J].中华皮肤科杂志,2015,48(7):177-181.
[12]朱翠娣.口腔扁平苔藓的中医辨证与免疫功能微循环的关系探讨[J].口腔医学杂志,1998,9(3):148-149.
[13]高学敏.中药学[M].北京:中国中医药出版社,2007.
[14]胡芳,李健,万燕燕.中西医结合治疗口腔扁平苔藓64例临床观察[J].世界中西医结合杂志,2012,7(6):490-491.