中药复方治疗脾虚痰湿型多囊卵巢综合征疗效观察
|
摘要
目的观察中药复方治疗脾虚痰湿型多囊卵巢综合征(PCOS)的有效性,为中医药治疗PCOS提供客观依据。方法根据鹿特丹标准及中医脾虚痰湿证诊断标准纳入60例脾虚痰湿型PCOS患者,口服同一中药复方治疗3个月经周期。治疗前后,观察纳入患者的性激素、血糖、胰岛素、HOMA-IR、TG、TC、HDL-C、LDL-C、APOA、APOB、LPA、体重、BMI、腰围、臀围、WHR和多毛、痤疮、黑棘皮、溢脂的改善情况以及排卵率。结果中药治疗3个月经周期后,患者LH/FSH、T、AND、SHBG、FINS、TG、HDL-C、体重、BMI、腰围、臀围、溢脂百分率和多毛评分较治疗前明显改善,差异均有统计学意义(P<0.05,P<0.01)。根据血清孕酮的结果判断排卵情况,计算每个月经周期的排卵率分别为25.00%,38.33%,56.67%,总排卵率为40.00%。结论中药复方对脾虚痰湿型PCOS患者的性激素水平、糖脂代谢、人体测量学指标和排卵功能有改善作用。
Objective To observe the effectiveness of compound herbal medicine formula in the treatment of polycystic ovary syndrome(PCOS) differentiated as spleen deficiency and phlegm damp so as to provide the objective evidence for the treatment of PCOS in TCM. Methods According to the Rotterdam consensus criteria and the diagnostic criteria of spleen deficiency and phlegm damp syndrome in TCM,60 patients of PCOS of spleen deficiency and phlegm damp syndrome in TCM were included. The patients were treated with the same compound herbal medicine formula for oral administration for 3 menstrual cycles. Before and after treatment,the sex hormone,blood glucose,insulin,HOM-IR,TG,TC,HDL-C,LDL-C,APOA,APOB,LPA,body weight,BMI,waistline,hipline,WHR,hirsutism,acne,acanthosis-nigricans and seborrhea as well ovulation rate were observed. Results After treated with herbal medicine for 3 menstrual cycles,LH/FSH,T,AND,SHBG,FINS,TG,HDL-C,body weight,BMI,waistline,hipline and seborrhea percentage as well as hirsutism score were all remarkably improved as compared with those before treatment,indicating the significant differences(P < 0. 05,P < 0. 01). The serum progesterone result was taken to justify the ovulation.The ovulation rates were 25. 00%,38. 33% and 56. 67% separately in each month. The total ovulation rate was 40. 00%. Conclusion The compound herbal medicine formula improves in the sex hormone level,glucolipid metabolism,anthropometric indexes and ovulation function in the patients of PCOS of spleen deficiency and phlegm damp pattern in TCM.
Objective To observe the effectiveness of compound herbal medicine formula in the treatment of polycystic ovary syndrome(PCOS) differentiated as spleen deficiency and phlegm damp so as to provide the objective evidence for the treatment of PCOS in TCM. Methods According to the Rotterdam consensus criteria and the diagnostic criteria of spleen deficiency and phlegm damp syndrome in TCM,60 patients of PCOS of spleen deficiency and phlegm damp syndrome in TCM were included. The patients were treated with the same compound herbal medicine formula for oral administration for 3 menstrual cycles. Before and after treatment,the sex hormone,blood glucose,insulin,HOM-IR,TG,TC,HDL-C,LDL-C,APOA,APOB,LPA,body weight,BMI,waistline,hipline,WHR,hirsutism,acne,acanthosis-nigricans and seborrhea as well ovulation rate were observed. Results After treated with herbal medicine for 3 menstrual cycles,LH/FSH,T,AND,SHBG,FINS,TG,HDL-C,body weight,BMI,waistline,hipline and seborrhea percentage as well as hirsutism score were all remarkably improved as compared with those before treatment,indicating the significant differences(P < 0. 05,P < 0. 01). The serum progesterone result was taken to justify the ovulation.The ovulation rates were 25. 00%,38. 33% and 56. 67% separately in each month. The total ovulation rate was 40. 00%. Conclusion The compound herbal medicine formula improves in the sex hormone level,glucolipid metabolism,anthropometric indexes and ovulation function in the patients of PCOS of spleen deficiency and phlegm damp pattern in TCM.
引文
[1]Rotterdam ESHRE/ASRM-Sponsored PCOS consensus work-shop group.Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syn-drome(PCOS)[J].Hum Reprod,2004,19(1):41-47.
[2]张春兰,侯丽辉,李妍,等.侯丽辉教授治疗多囊卵巢综合征经验总结[J].四川中医,2015,33(8):12-15.
[3]孟小钰,王桂媛,王颖,等.不同中医证型多囊卵巢综合征患者临床特点分析:基于临床科研信息一体化平台[J].实用妇科内分泌杂志,2015,2(2):36-39.
[4]陈宇,任健,刘家义,等.燥湿化痰药治疗多囊卵巢综合征痰湿证的机制研究[J].山东中医杂志,2013,32(5):307-308.
[5]李晓倩,沈山梅,毕艳,等.健脾化痰方对大鼠胰岛素抵抗及慢性炎症因子的影响[J].中华中医药学刊,2013,31(11):2541-2544.
[6]Fu J,Wang Z,Huang L,et al.Review of the botanical characteristics,phytochemistry,and pharmacology of Astragalus membranaceus(Huangqi)[J].Phytotherapy Research,2014,28(9):1275-1283.
[7]Zhang K,Pugliese M,Pugliese A,et al.Biological active ingredients of traditional Chinese herb Astragalus membranaceus on treatment of diabetes:a systematic review[J].Mini Rev Med Chem,2015,15(4):315-329.
[8]严荣.丹参酮药用进展分析[J].亚太传统医药,2013,9(12):85-86.
[9]Kim CK,Kim M,Oh SD,et al.Effects of Atractylodes macrocephala Koidzumi rhizome on 3T3-L1 adipogenesis and an animal model of obesity[J].J Ethnopharmacol,2011,137(1):396-402.
[10]苗华,张旭.茯苓结合有氧运动对大鼠基于代谢组学表征的血脂紊乱相关指标的影响[J].中国运动医学杂志,2013,32(11):1013-1017.
[11]李慧,杨中林.橙皮苷降血脂作用的试验研究[J].中医药学报,2010,38(1):23-24.
[2]张春兰,侯丽辉,李妍,等.侯丽辉教授治疗多囊卵巢综合征经验总结[J].四川中医,2015,33(8):12-15.
[3]孟小钰,王桂媛,王颖,等.不同中医证型多囊卵巢综合征患者临床特点分析:基于临床科研信息一体化平台[J].实用妇科内分泌杂志,2015,2(2):36-39.
[4]陈宇,任健,刘家义,等.燥湿化痰药治疗多囊卵巢综合征痰湿证的机制研究[J].山东中医杂志,2013,32(5):307-308.
[5]李晓倩,沈山梅,毕艳,等.健脾化痰方对大鼠胰岛素抵抗及慢性炎症因子的影响[J].中华中医药学刊,2013,31(11):2541-2544.
[6]Fu J,Wang Z,Huang L,et al.Review of the botanical characteristics,phytochemistry,and pharmacology of Astragalus membranaceus(Huangqi)[J].Phytotherapy Research,2014,28(9):1275-1283.
[7]Zhang K,Pugliese M,Pugliese A,et al.Biological active ingredients of traditional Chinese herb Astragalus membranaceus on treatment of diabetes:a systematic review[J].Mini Rev Med Chem,2015,15(4):315-329.
[8]严荣.丹参酮药用进展分析[J].亚太传统医药,2013,9(12):85-86.
[9]Kim CK,Kim M,Oh SD,et al.Effects of Atractylodes macrocephala Koidzumi rhizome on 3T3-L1 adipogenesis and an animal model of obesity[J].J Ethnopharmacol,2011,137(1):396-402.
[10]苗华,张旭.茯苓结合有氧运动对大鼠基于代谢组学表征的血脂紊乱相关指标的影响[J].中国运动医学杂志,2013,32(11):1013-1017.
[11]李慧,杨中林.橙皮苷降血脂作用的试验研究[J].中医药学报,2010,38(1):23-24.