硫熏中药材品质及其毒理学研究进展
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摘要
硫磺熏蒸是我国传统中药材干燥的一种加工方法,该方法具有杀虫、防霉、防腐和增白等功效。近年来研究发现,硫磺熏蒸会导致中药材某些活性成分转化生成新的含硫衍生物,导致其在人体的代谢过程和药效发生改变,甚至引发毒性反应,存在安全隐患。本文在现有文献的基础上归纳总结硫元素的各种形态、硫磺熏蒸中药材化学成分的转化规律及其毒理学研究,为进一步评价硫熏工艺的合理性研究提供理论参考。
Sulfur fumigation is a traditional drying method to prevent Chinese medicine materials from insects,molds and erosion etc,and can be used to bleach them. In recent years,investigations have found that the certain active components of traditional Chinese medicine( TCM) can be transformed into sulfur-containing derivatives in the process of sulfur fumigation,resulting in changes of metabolism and pharmacodynamics in the body,and even production of toxic reactions. This paper comprehensively summarizes the various morphologies of sulfur elements,chemical transformation rules of TCM and the toxicological studies in sulfur-fumigation. The review would provide valuable references for further evaluating the rationality of sulfur fumigation process of TCM.
Sulfur fumigation is a traditional drying method to prevent Chinese medicine materials from insects,molds and erosion etc,and can be used to bleach them. In recent years,investigations have found that the certain active components of traditional Chinese medicine( TCM) can be transformed into sulfur-containing derivatives in the process of sulfur fumigation,resulting in changes of metabolism and pharmacodynamics in the body,and even production of toxic reactions. This paper comprehensively summarizes the various morphologies of sulfur elements,chemical transformation rules of TCM and the toxicological studies in sulfur-fumigation. The review would provide valuable references for further evaluating the rationality of sulfur fumigation process of TCM.
引文
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[2] X Jiang,L P Huang,S H Zheng et al. J. Sci. Food. Agric.,2013,93:2963~2972.
[3]康传志,杨婉珍,莫歌等.中国中药杂志,2018,43(2):242~247.
[4] K Pei,H Cai,X Liu et al. J. Sep. Sci.,2015,38(1):25~33.
[5]康传志,蒋靖怡,杨婉珍等.中国中药杂志,2018,43(2):248~253.
[6]马晓青,蔡皓,刘晓等.药物分析杂志,2011,31(6):1031~1034.
[7]王学成,伍振峰,万娜等.中国实验方剂学杂志,2018,24(03):36~40.
[8]唐进法,张书琦,王晓艳等.中国中药杂志,2018,43(9):1871~1879.
[9] J Liu,H Cai,X Liu et al. J. Chin. Med.,2011,36(13):1790~1793.
[10] H Zhang,J Chen,H Xiong et al. Org. Biomol. Chem.,2019,17(06):1~6.
[11] F K Tittel,H Wu,H Zheng et al. Optics Express,2017,25(26):32581~32590.
[12]李晓峰,陈梁,董拯等.化学分析计量,2016,25(3):101~105.
[13]刘红平,朱永恒,刘海泉等.食品科学,2017,38(16):228~233.
[14]张振兴.价值工程,2017,36(20):115~117.
[15]袁向辉.陕西中医药大学硕士学位,2011.
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[20] L Dan,H Duan,Y Ma et al. Anal. Chem.,2018,90(09):5719~5727.
[21]郑新元,徐美宝,吴娱等.药物分析杂志,2016,36(01):129~132.
[22] X X Cui,H H Yi,X L Tang et al. J. Chem. Technol.Biotechnol.,2018,93(3):720~729.
[23] V N Rad,M Anbia,M H Sadr. J. Environ. Sci-China.,2018,15(3):631~636.
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[27]武洁,徐亚运,孔铭等.中国实验方剂学杂志,2018,24(05):20~24.
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[36]金辉,吴平安,刘峰林等.甘肃中医学院学报,2012,29(5):73~76.
[37]尚展鹏,王菲,王子健等.质谱学报,2018,39(2):180~191.
[38]杜伟锋,张浩,岳显可等.中国药学杂志,2016,51(08):659~662.
[39] J D Xu,Q Mao,H Shen et al. J. Chromatogr. A.,2013,13(4):154~168.
[40]张丽,沈红,董河等.中医药学报,2017,45(3):103~107.
[41] S L Li,S Hong,L Y Zhu et al. J. Chromatogr. A.,2012,31(12):31~45.
[42] B Ma,W L Kan,H Zhu et al. J. Ethnopharmcol.,2017,195:222~230.
[43] A L Guo,L M Chen,Y M Wang et al. Molecules,2014,19(10):16640~16655.
[44]李成义,魏学明,王明伟等.中国现代中药,2010,12(12):11~13.
[45] X Q Ma,A K Leung,C L Chan et al. Analyst,2014,139(2):505~516.
[46] P Y Hayes,R Lehmann,K Penman et al. Tetrahed. Lett.,2005,46(15):2615~2618.
[47] S L Li,J Z Song,F F Choi et al. J. Pharm. Biomed. Anal.,2009,49(2):253~266.
[48] M Kong,H H Liu,J Xu et al. J. Pharm. Biomed. Anal.,2014,98(10):424~433.
[49] M Kong,H H Liu,J Wu et al. J. Ethnopharmacol.,2018,212:95~105.
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[51] X Y Li,J D Xu,J Xu et al. Anal. Methods-UK.,2016,8(5):1034~1043.
[52] Y J Bai,J D Xu,M Kong et al. Food. Res. Int.,2015,76:387~394.
[53] Y X Zhan,P Yao,W C Bi et al. Phytomedicine,2014,21(11):1318~1324.
[54] H Cai,G Cao,L Li et al. Molecules,2013,18(2):1368~1382.
[55] Z Y Li,H M Gao,J Sun et al. Helv. Chim. Acta.,2012,95(7):1144~1151.
[56]郭爱丽.中国中药杂志,2014,39(9):1639~1643.
[57] J B S Braveman. J. Sci. Food. Agric.,2010,4(11):540~547.
[58]席啸虎,王世伟,仝立国等.中国医院药学杂志,2017,37(11):613~616.
[59]席啸虎,刘瑢,刘霞.中草药,2017,48(7):1327~1333.
[60]吴晓毅,巢志茂,王梦缘等.中国中医药信息杂志,2014,21(8):85~88.
[61] X H Wang,P S Xie,C W Lam et al. J. Pharm. Biomed.Anal.,2009,49(5):1221~1225.
[62]卢晓琳,蒋运斌,袁茂华等.中药与临床,2015,6(5):39~43.
[63]靳灿灿,李会军.中成药,2014,36(8):1706~1710.
[64] S Wang,L J Hao,J J Zhu et al. Phytomedicine,2014,21(5):773~779.
[65] X Y Xing,Z H Sun,M H Yang et al. Molecules,2018,23(10):2609.
[66] C Z Kang,Z Dan,L P Kang et al. Front. Plant. Sci.,2018,(1):790~802.
[67] X Q Ma,S M Li,T Su et al. Chin. Med-UK,2016,11(1):32~44.
[68]王亚君,郭巧生,杨秀伟等.中国中药杂志,2007,32(9):808~813.
[69] K Ding,G Cao,Z Xu et al. Nat. Prod. Commun.,2014,9(9):1357~1358.
[70] J W Zhao,C Y Zheng,H Wei et al. Chem-Biol. Interact.,2018,292:84~93.
[71] M H Yuan,Z G Yan,L Yuan et al. J. Ethnopharmacol.,2019,234:76~84.
[72]陈仁山,蒋淼,陈思敏等.中药与临床,2010,1(1):58~61.
[73] B Duan,L Huang,S Chen. Phytomedicine,2012,19(6):562~568.
[74]康传志,杨婉珍,周利等.中国中药杂志,2018,43(2):254~260.
[75] J He,Y He,C Zhang. Molecules,2017,22(9):1402.
[76] Z L Zhan,A P Deng,L P Kang et al. J. Pharm. Biomed.Anal.,2018,156:340~348.
[77] L He,Z Zhang,Y Liu et al. Food. Res. Int.,2018,108:226~236.
[78] L Zhang,H Shen,J Xu et al. Food. Chem.,2017,246:202~210.
[79] D Liu,F Galvanin,Y Yu. AAPS. PharmSciTech.,2018,19(2):1~10.
[80] M H Mirjalili,P Salehi,M M Vala et al. Ind. J. Plant.Physiol.,2019,(4):1~8.