不同腧穴配伍灸法联合美沙拉嗪治疗溃疡性结肠炎的平行对照研究
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摘要
目的探讨不同腧穴配伍灸法联合美沙拉嗪治疗溃疡性结肠炎的临床有效性及差异性。方法选择溃疡性结肠炎患者105例,随机分为治疗组、对照1组、对照2组,每组35例。3组均给予美沙拉嗪肠溶片治疗,灸法均采用隔药饼灸法,对照1组给予辨证取穴(天枢、大肠俞、足三里、丰隆);对照2组给予子午流注取穴;治疗组给予神阙八阵取穴。观察3组患者治疗前后细胞因子水平、中医症状、大肠黏膜积分变化。结果治疗后治疗组与对照1组、对照2组在细胞因子(Hs-CRP、IL-6、TNF-α)水平、中医症状积分(腹痛、腹泻、脓血便)、大肠黏膜积分方面比较,差异有统计学意义(P<0.05);治疗组、对照1组、对照2组临床疗效总有效率比较差异有统计学意义(P<0.05)。结论神阙八阵取穴灸法联合美沙拉嗪能明显改善溃疡性结肠炎的细胞因子水平及大肠黏膜情况,缓解临床症状,具有明显的优越性。
Objective To explore the clinical efficacy and different acupoints compatibility of moxibustion combined with beauty of salad in the treatment of ulcerative colitis. Methods A total of 105 patients with ulcerative colitis were randomly divided into treatment group,control group( n = 1) and control group( n = 35)( n = 2). The 3 groups were given basic treatment of oral 3/,Mesalazin Enteric-coated Tablets 1 g,are used in herbal cake separated moxibustion moxibustion,the control group was given 1 dialectical acupoints( Tianshu,Zusanli,Feng Long); the control group 2 given Ziwuliuzhu acupuncture; the treatment group was given acupoint Shenque eight array. The 3 groups of patients before and after treatment of cytokines,TCM symptoms,change in colorectal mucosal score. Results after treatment,the treatment group and the control group 1 and control group 2 on cytokines( Hs-CRP,IL-6,TNF-alpha) level,TCM symptoms( abdominal pain,diarrhea,pus and blood stool),colorectal mucosa score,there was significant difference( P < 0. 05); the treatment group and the control group 1,2 groups of photos the total curative rate were 91. 43%,80%,77. 14%,there was statistically significant difference( P < 0. 05). Conclusion Shenque acupoints moxibustion combined with the eight array of salad can significantly improve the level of cytokines in ulcerative colitis and colorectal mucosa,alleviate the clinical symptoms,has obvious superiority.
Objective To explore the clinical efficacy and different acupoints compatibility of moxibustion combined with beauty of salad in the treatment of ulcerative colitis. Methods A total of 105 patients with ulcerative colitis were randomly divided into treatment group,control group( n = 1) and control group( n = 35)( n = 2). The 3 groups were given basic treatment of oral 3/,Mesalazin Enteric-coated Tablets 1 g,are used in herbal cake separated moxibustion moxibustion,the control group was given 1 dialectical acupoints( Tianshu,Zusanli,Feng Long); the control group 2 given Ziwuliuzhu acupuncture; the treatment group was given acupoint Shenque eight array. The 3 groups of patients before and after treatment of cytokines,TCM symptoms,change in colorectal mucosal score. Results after treatment,the treatment group and the control group 1 and control group 2 on cytokines( Hs-CRP,IL-6,TNF-alpha) level,TCM symptoms( abdominal pain,diarrhea,pus and blood stool),colorectal mucosa score,there was significant difference( P < 0. 05); the treatment group and the control group 1,2 groups of photos the total curative rate were 91. 43%,80%,77. 14%,there was statistically significant difference( P < 0. 05). Conclusion Shenque acupoints moxibustion combined with the eight array of salad can significantly improve the level of cytokines in ulcerative colitis and colorectal mucosa,alleviate the clinical symptoms,has obvious superiority.
引文
[1]谢晶日,李泽洋.针灸治疗溃疡性结肠炎研究进展[J].针灸临床杂志,2013,29(10):69-71.
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[11]中华医学会消化病学分会炎症性肠病学组.我国炎症性肠病诊断与治疗的共识意见[J].内科理论与实践,2013,8(1):61-75.
[12]洪宗国.艾灸溯源[J].中南名族大学学报:自热科学版,2014,33(4):47-51.
[13]苏婷,石显方.溃疡性结肠炎的中医药治疗进展[J].光明中医,2013,28(9):1977-1980.
[14]徐锡年.从易学河图洛书探讨中医学阴阳理论方法论体系[J].上海中医药大学学报,2007,21(3):15-18.
[15]季光明,曲夷.经络平衡特点探究[J].山东中医杂志,2014,33(9):716-718.
[2]沈洪,朱磊.重视溃疡性结肠炎的中西医结合治疗[J].中国中西医结合消化杂志,2016,24(8):571-574.
[3]张运希,汤建光,苏东平.中药内服加灌肠治疗溃疡性结肠炎临床研究[J].光明中医,2016,30(5):1225-1226.
[4]刘进,李丹,杨雪山.溃疡性结肠炎中医综合疗法概况[J].世界中西医结合杂志,2009,4(10):753-755.
[5]中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见[J].中华内科杂志,2012,51(10):818-831.
[6]中华中医药学会脾胃病分会.溃疡性结肠炎中医诊疗共识(2009)[J].中国中西医结合杂志,2010,30(5):527-532.
[7]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:129-134.
[8]申治富,余思奕,胡幼平.杵针疗法的理论及临床运用[J].上海针灸杂志,2015,36(6):575-578.
[9]石学敏.针灸学[M].北京:中国医药科技出版社,2007:250.
[10]漆浩,董晔.子午流注、灵龟飞腾八法大全[M].北京:中国医药科技出版社,1993:224.
[11]中华医学会消化病学分会炎症性肠病学组.我国炎症性肠病诊断与治疗的共识意见[J].内科理论与实践,2013,8(1):61-75.
[12]洪宗国.艾灸溯源[J].中南名族大学学报:自热科学版,2014,33(4):47-51.
[13]苏婷,石显方.溃疡性结肠炎的中医药治疗进展[J].光明中医,2013,28(9):1977-1980.
[14]徐锡年.从易学河图洛书探讨中医学阴阳理论方法论体系[J].上海中医药大学学报,2007,21(3):15-18.
[15]季光明,曲夷.经络平衡特点探究[J].山东中医杂志,2014,33(9):716-718.