新疆体检人群代谢综合征组分与高同型半胱氨酸血症的相关性
|
摘要
目的探讨体检人群代谢综合征(MS)组分与高同型半胱氨酸血症(HHcy)的相关性,为HHcy的防控提供科学依据。方法选择2017年1-10月新疆医科大学第一附属医院7 492例体检者为研究对象,进行问卷调查、体格检查及血生化检测。采用SPSS 22.0统计软件进行t检验及χ2检验。采用多因素逐步向前logistic回归分析HHcy患病的危险因素,采用单因素及多因素logistic回归分析MS组分数目与HHcy的相关性。结果在控制混杂因素后,多因素logistic回归分析结果显示,4项MS组分,即中心性肥胖(OR=1.35,95%CI:1.05～1.69)、高血糖(OR=1.24,95%CI:1.10～1.38)、高血压(OR=1.66,95%CI:1.46～1.83)和甘油三酯升高(OR=1.25,95%CI:1.02～1.52)是HHcy的危险因素(P<0.05,P<0.01)。1、2、3、4和5个MS组分的调查对象发生HHcy的风险分别是0个MS组分的调查对象的1.32倍(OR=1.32,95%CI:1.09～1.76)、1.94倍(OR=1.94,95%CI:1.63～2.99)、3.01倍(OR=3.01,95%CI:2.02～4.35)、4.47倍(OR=4.47,95%CI:2.76～5.71)和4.39倍(OR=4.39,95%CI:3.01～5.86)。结论中心性肥胖、高血糖、高血压、甘油三酯升高与新疆地区体检人群HHcy患病相关。MS人群应积极运动,养成良好的生活习惯和饮食习惯,降低血压、血糖、血脂水平,以控制同型半胱氨酸水平。
Objective To explore the correlation between metabolic syndrome(MS) components and hyperhomocysteinemia(HHcy)in residents with physical examination of Xinjiang area,and to provide the scientific evidence for the prevention of HHcy.Methods From January to October in 2017,7 492 residents with physical examination in the First Affiliated Hospital of Xinjiang Medical University served as the subjects. The investigation was performed by questionnaire,physical examination and blood biochemical test. The multivariate stepwise forward logistic regression was used to analyze the risk factors of HHcy. Univariate and multivariate logistic regression were used to analyze the correlation between the number of MS components and HHcy. Results After controlling the confounding factors,multivariate logistic regression analysis showed that four abnormal MS components,i.e.central obesity(OR=1.35,95%CI:1.05-1.69),hyperglycemia(OR=1.24,95%CI:1.10-1.38),hypertension(OR=1.66,95%CI:1.46-1.83) and elevated triglyceride(OR =1.25,95%CI:1.02-1.52) were risk factors for HHcy,P<0.05,P<0.01. And the risk of HHcy in one,two,three,four and five abnormal MS components groups was 1.32(OR=1.32,95%CI:1.09-1.76),1.94(OR=1.94,95%CI:1.63-2.99),3.01(OR=3.01,95%CI:2.02-4.35),4.47(OR=4.47,95%CI:2.76-5.71) and 4.39(OR=4.39,95%CI:3.01-5.86) folds than the zero abnormal MS component group. Conclusion Central obesity,hyperglycemia,hypertension,elevated triglyceride were correlated with the occurrence of HHcy in the residents with physical examination of Xinjiang area.MS residents should actively exercise,develop good habits and dietary habits to reduce blood pressure,blood sugar,blood lipid levels for controlling the homocysteine level.
Objective To explore the correlation between metabolic syndrome(MS) components and hyperhomocysteinemia(HHcy)in residents with physical examination of Xinjiang area,and to provide the scientific evidence for the prevention of HHcy.Methods From January to October in 2017,7 492 residents with physical examination in the First Affiliated Hospital of Xinjiang Medical University served as the subjects. The investigation was performed by questionnaire,physical examination and blood biochemical test. The multivariate stepwise forward logistic regression was used to analyze the risk factors of HHcy. Univariate and multivariate logistic regression were used to analyze the correlation between the number of MS components and HHcy. Results After controlling the confounding factors,multivariate logistic regression analysis showed that four abnormal MS components,i.e.central obesity(OR=1.35,95%CI:1.05-1.69),hyperglycemia(OR=1.24,95%CI:1.10-1.38),hypertension(OR=1.66,95%CI:1.46-1.83) and elevated triglyceride(OR =1.25,95%CI:1.02-1.52) were risk factors for HHcy,P<0.05,P<0.01. And the risk of HHcy in one,two,three,four and five abnormal MS components groups was 1.32(OR=1.32,95%CI:1.09-1.76),1.94(OR=1.94,95%CI:1.63-2.99),3.01(OR=3.01,95%CI:2.02-4.35),4.47(OR=4.47,95%CI:2.76-5.71) and 4.39(OR=4.39,95%CI:3.01-5.86) folds than the zero abnormal MS component group. Conclusion Central obesity,hyperglycemia,hypertension,elevated triglyceride were correlated with the occurrence of HHcy in the residents with physical examination of Xinjiang area.MS residents should actively exercise,develop good habits and dietary habits to reduce blood pressure,blood sugar,blood lipid levels for controlling the homocysteine level.
引文
[1]秦江梅,张艳春,张丽芳,等.典型城市居民慢性病患病率及患者疾病负担分析[J].中国公共卫生,2014,30(1):5-7.
[2]商鲁翔,满姗姗,张华,等.济南和青岛地区中老年心脑血管病高危人群同型半胱氨酸水平调查[J].中国慢性病预防与控制,2016,24(12):899-903.
[3]赵彦楠,杨博逸,孙贵范.同型半胱氨酸与主要慢性病关系研究进展[J].中国公共卫生,2015,31(2):241-245.
[4]何秉贤.同型半胱氨酸及其在心血管病中的意义和防治现状[J].中华高血压杂志,2016,24(4):317-319.
[5]冯胜强,叶平,骆雷鸣,等.北京市1680名社区居民血清同型半胱氨酸与代谢综合征关系的横断面研究[J].中华流行病学杂志,2012,33(3):256-259.
[6]李响,李淑红,李琳.成人血清同型半胱氨酸水平与代谢综合征及各组分的关系[J].中华临床营养杂志,2016,24(3):139-143.
[7]申秀敏,李亚峰,范雪梅,等.同型半胱氨酸与代谢综合征各因素的相关性研究[J].中国药物与临床,2013,13(11):1411-1415.
[8]中国成人血脂异常防治指南修订联合委员会.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志,2016,16(10):15-35.
[9]刘成,马翔,马依彤,等.新疆地区汉族、维吾尔族、哈萨克族成年人群超重和肥胖流行病学调查[J].中华流行病学杂志,2010,31(10):1139-1143.
[10] Sreckovic B,Sreckovic VD,Soldatovic I,et al. Homocysteine is a marker for metabolic syndrome and atherosclerosis[J]. Diabetes Metab Syndr,2017,11(3):179-182.
[11]徐祥凤,杨文东.中青年超重和肥胖与高血压及高同型半胱氨酸血症的相关性研究[J].实用心脑肺血管病杂志,2014,22(5):20-21.
[12]王雁,王伯忠,项巧珍,等.高强度运动对高同型半胱氨酸血症大鼠抗氧化和内皮功能的影响[J].浙江预防医学,2017,29(6):550-554.
[13]何菲,马儒林,牛强,等.新疆汉族和维吾尔族人群糖尿病流行现状调查及影响因素分析[J].中国糖尿病杂志,2015,23(1):3-6.
[14]张燕,王广,刘佳,等. H型高血压与胰岛素抵抗的关系研究[J].中国全科医学,2016,19(19):2271-2274.
[2]商鲁翔,满姗姗,张华,等.济南和青岛地区中老年心脑血管病高危人群同型半胱氨酸水平调查[J].中国慢性病预防与控制,2016,24(12):899-903.
[3]赵彦楠,杨博逸,孙贵范.同型半胱氨酸与主要慢性病关系研究进展[J].中国公共卫生,2015,31(2):241-245.
[4]何秉贤.同型半胱氨酸及其在心血管病中的意义和防治现状[J].中华高血压杂志,2016,24(4):317-319.
[5]冯胜强,叶平,骆雷鸣,等.北京市1680名社区居民血清同型半胱氨酸与代谢综合征关系的横断面研究[J].中华流行病学杂志,2012,33(3):256-259.
[6]李响,李淑红,李琳.成人血清同型半胱氨酸水平与代谢综合征及各组分的关系[J].中华临床营养杂志,2016,24(3):139-143.
[7]申秀敏,李亚峰,范雪梅,等.同型半胱氨酸与代谢综合征各因素的相关性研究[J].中国药物与临床,2013,13(11):1411-1415.
[8]中国成人血脂异常防治指南修订联合委员会.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志,2016,16(10):15-35.
[9]刘成,马翔,马依彤,等.新疆地区汉族、维吾尔族、哈萨克族成年人群超重和肥胖流行病学调查[J].中华流行病学杂志,2010,31(10):1139-1143.
[10] Sreckovic B,Sreckovic VD,Soldatovic I,et al. Homocysteine is a marker for metabolic syndrome and atherosclerosis[J]. Diabetes Metab Syndr,2017,11(3):179-182.
[11]徐祥凤,杨文东.中青年超重和肥胖与高血压及高同型半胱氨酸血症的相关性研究[J].实用心脑肺血管病杂志,2014,22(5):20-21.
[12]王雁,王伯忠,项巧珍,等.高强度运动对高同型半胱氨酸血症大鼠抗氧化和内皮功能的影响[J].浙江预防医学,2017,29(6):550-554.
[13]何菲,马儒林,牛强,等.新疆汉族和维吾尔族人群糖尿病流行现状调查及影响因素分析[J].中国糖尿病杂志,2015,23(1):3-6.
[14]张燕,王广,刘佳,等. H型高血压与胰岛素抵抗的关系研究[J].中国全科医学,2016,19(19):2271-2274.