河北省某三甲医院2005年-2017年甲状腺疾病住院手术患者构成变化分析
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摘要
目的了解河北省某三甲医院13年间甲状腺疾病手术患者构成的变化,分析甲状腺恶性肿瘤病理学特点,探究甲状腺疾病的变化趋势。方法收集2005年-2017年河北省某三甲医院行甲状腺手术并取得病理结果患者的临床资料,回顾性分析患者基本情况,比较不同特征人群、不同年份甲状腺疾病和甲状腺恶性肿瘤构成变化。结果 13年间甲状腺疾病手术患者明显增加,结节性甲状腺肿、甲状腺恶性肿瘤增长明显。甲状腺恶性肿瘤构成比增加,从2005年的11.5%到2017年的40.4%。其中乳头状癌持续增高,尤其是微小乳头状癌的构成比明显增高,2005年微小乳头状癌占甲状腺疾病比例仅为11.8%,2017年达72.5%。结论甲状腺疾病住院手术患者病种及甲状腺恶性肿瘤病理类型构成发生了变化;甲状腺恶性肿瘤的构成比呈上升趋势,尤其是微小乳头状癌。应加强对甲状腺微小乳头状癌的认识,进一步寻找相关危险因素及预防措施。
Objective To understand the changes in the composition of patients with thyroid disease during the13 years in Hebei General hospital,analyze the pathological features of thyroid carcinoma,and explore the trends of thyroid disease. Methods The clinical data of patients with thyroid surgery and pathological results in Hebei General Hospital from 2005 to 2017 were collected. The basic conditions of patients were retrospectively analyzed. The constituent ratio of thyroid diseases and thyroid carcinoma in different characteristics and different years were compared. Results The number of thyroid disease surgery in our hospital increased significantly during the 13 years,and the growth of nodular goiter and thyroid carcinoma was obvious. The composition ratio of thyroid carcinoma increased from 11.5% in 2005 to 40.4% in 2017. Papillary thyroid carcinoma continues to increase, especially the constituent ratio of thyroid micropapillary carcinoma is significantly increased.In 2005, the constituent ratio of thyroid micropapillary carcinoma in thyroid disease was only 11.8%, and it was 72.5% in 2017. Conclusion The constituent of thyroid diseases and thyroid carcinoma have changed;the constituent ratio is on the rise,especially in thyroid micropapillary carcinoma.The understanding of thyroid micropapillary carcinoma should be strengthened to further explore relevant risk factors and preventive measures.
Objective To understand the changes in the composition of patients with thyroid disease during the13 years in Hebei General hospital,analyze the pathological features of thyroid carcinoma,and explore the trends of thyroid disease. Methods The clinical data of patients with thyroid surgery and pathological results in Hebei General Hospital from 2005 to 2017 were collected. The basic conditions of patients were retrospectively analyzed. The constituent ratio of thyroid diseases and thyroid carcinoma in different characteristics and different years were compared. Results The number of thyroid disease surgery in our hospital increased significantly during the 13 years,and the growth of nodular goiter and thyroid carcinoma was obvious. The composition ratio of thyroid carcinoma increased from 11.5% in 2005 to 40.4% in 2017. Papillary thyroid carcinoma continues to increase, especially the constituent ratio of thyroid micropapillary carcinoma is significantly increased.In 2005, the constituent ratio of thyroid micropapillary carcinoma in thyroid disease was only 11.8%, and it was 72.5% in 2017. Conclusion The constituent of thyroid diseases and thyroid carcinoma have changed;the constituent ratio is on the rise,especially in thyroid micropapillary carcinoma.The understanding of thyroid micropapillary carcinoma should be strengthened to further explore relevant risk factors and preventive measures.
引文
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[14]关海霞,单忠艳,米小轶,等.普遍食盐碘化前后甲状腺癌发病变化的11年病理资料分析[J].中国医科大学学报,2006,35(3):284-285.
[15]Sehestedt T,Knudsen N,Perrild H,et al.Iodine intake and incidence of thyroid cancer in Denmark[J].Clin Endocrinol(Oxf),2006,65(2):229-233.
[2]Jemal A,Siegel R,Xu J,et al.Cancer statistics,2010[J].CACancer J Clin,2010,60(5):277-300.
[3]Chen A Y,Jemal A,Ward E M.Increasing incidence of differentiated thyroid cancer in the United States,1988-2005[J].Cancer,2009,115(16):3801-3807.
[4]Sipos J A,Mazzaferri E L.Thyroid cancer epidemiology and prognostic variables[J].Clin Oncol(R Coll Radiol),2010,22(6):395-404.
[5]孙嘉伟,许晓君,蔡秋茂,等.中国甲状腺癌发病趋势分析[J].中国肿瘤,2013,22(09):690-693.
[6]师金,梁迪,李道娟,等.河北省2014年恶性肿瘤发病与死亡情况分析[J].肿瘤,2018,38(04):329-338.
[7]李晓静,蒋玲,娄萍萍.甲状腺癌临床及病理学特点的回顾性分析[J].中华内分泌代谢杂志,2013,29(12):1010-1014.
[8]Ron E,Brenner A.Non-malignant thyroid diseases after a wide range of radiation exposures[J].Radiat Res,2010,174(6):877-888.
[9]Stewart F A,Akleyev A V,Hauerjensen M,et al.ICRPPUBLICATION 118:ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs-Threshold Doses for Tissue Reactions in a Radiation Protection Context[J].Ann Icrp,2012,41(1-2):1-322.
[10]韩晴,黄汉林.广州市区部分三甲医院放射工作人员甲状腺异常及影响因素调查[J].中国职业医学,2015,42(02):141-146.
[11]Jin J,McHenry C R.Thyroid incidentaloma[J].Best Pract Res Clin Endocrinol Metab,2012,26(1):83-96.
[12]Kitahara C M,Platz E A,Park Y,et al.Body fat distribution,weight change during adulthood,and thyroid cancer risk in the NIH‐AARP Diet and Health Study[J].International Journal of Cancer,2012,130(6):1411-1419.
[13]Renehan A G,Tyson M,Egger M,et al.Body-mass index and incidence of cancer:a systematic review and metaanalysis of prospective observational studies[J].Lancet,2008,371(9612):569-578.
[14]关海霞,单忠艳,米小轶,等.普遍食盐碘化前后甲状腺癌发病变化的11年病理资料分析[J].中国医科大学学报,2006,35(3):284-285.
[15]Sehestedt T,Knudsen N,Perrild H,et al.Iodine intake and incidence of thyroid cancer in Denmark[J].Clin Endocrinol(Oxf),2006,65(2):229-233.