抗菌类西药临床应用的不良反应研究
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摘要
目的分析抗菌类西药临床应用的不良反应。方法随机抽取该院2017年6月—2018年8月期间收治的抗菌类西药治疗患者300例,回顾患者临床资料,统计抗菌类药物不良反应的发生。结果 63例抗菌类西药不良反应,男性65.08%,女性34.92%;以≥40岁人群为主;多见头孢菌素类、喹诺酮类及β-内酰胺类药物;给药途径多见静脉滴注、口服;单一用药63.49%,联合用药36.51%;不良反应多累及皮肤及附件、消化系统、神经系统;排在前5位药物为左氧氟沙星、哌拉西林/三唑巴坦钠、哌拉西林/舒巴坦、五水头孢唑林钠、头孢哌酮/舒巴坦。结论抗菌类西药使用期间,临床应严格按照说明书,对症用药。
Objective To analyze the adverse reactions of clinical application of antibacterial western medicine. Methods A total of 300 patients with antibacterial western medicine treated in our hospital from June 2017 to August 2018 were randomly selected. The clinical data of patients were reviewed and the occurrence of adverse reactions of antibacterial drugs was counted. Results 63 cases of antibacterial western medicine adverse reactions, male 65.08%, female 34.92%; mainly ≥40 years old; more common cephalosporins, quinolones and β-lactam drugs; intravenous route infusion more common oral;63.49% single drug, 36.51% combined; adverse reactions mostly affect the skin and accessories, digestive system, nervous system; the top five drugs are levofloxacin, piperacillin/tazobactam sodium, piperacillin/Sulbactam, cefazolin sodium pentahydrate, cefoperazone/sulbactam. Conclusion During the use of antibacterial western medicine, the clinical should be strictly in accordance with the instructions, symptomatic medication.
Objective To analyze the adverse reactions of clinical application of antibacterial western medicine. Methods A total of 300 patients with antibacterial western medicine treated in our hospital from June 2017 to August 2018 were randomly selected. The clinical data of patients were reviewed and the occurrence of adverse reactions of antibacterial drugs was counted. Results 63 cases of antibacterial western medicine adverse reactions, male 65.08%, female 34.92%; mainly ≥40 years old; more common cephalosporins, quinolones and β-lactam drugs; intravenous route infusion more common oral;63.49% single drug, 36.51% combined; adverse reactions mostly affect the skin and accessories, digestive system, nervous system; the top five drugs are levofloxacin, piperacillin/tazobactam sodium, piperacillin/Sulbactam, cefazolin sodium pentahydrate, cefoperazone/sulbactam. Conclusion During the use of antibacterial western medicine, the clinical should be strictly in accordance with the instructions, symptomatic medication.
引文
[1]肖文静.60例头孢菌素类抗菌药物与其他药物联合应用致不良反应[J].中国医院用药评价与分析,2016,16(4):549-551.
[2]李艳.抗菌类西药临床应用的不良反应研究[J].数理医药学杂志,2016, 29(2):248-249.
[3]王晓璐,刘阳,车云秀,等.某三甲医院2015—2017年抗菌类西药临床应用不良反应探究[J].临床军医杂志,2017,45(8):776-778.
[4]池善留.265例抗菌药物致不良反应报告[J].中国医院用药评价与分析,2016, 16(10):1412-1415.
[5]杨亚蕾.临床应用抗菌药物的不良反应观察[J].中国继续医学教育,2017,9(9):201-203.
[6]完晓建,杜洪玲.不合理使用抗菌药物致不良反应的原因分析[J].中国药物经济学, 2016,11(5):24-25.
[7]乐可佳,钟晗,施芳红.112例抗菌药物不良反应分析[J].医药导报,2016,35(s1):169-171.
[8]郑丽娜,李云霞,吴静.抗菌药物不良反应分析[J].中华医院感染学杂志,2016, 26(10):2378-2380.
[9]吕长淮. 159例氟喹诺酮类抗菌药物不良反应调查[J].中国医院用药评价与分析, 2016, 16(4):551-553.
[10]刘磊,岳彬.我院2012~2014年抗菌药物不良反应分布及相关因素分析[J].西南国防医药,2015,25(11):1219-1221.
[2]李艳.抗菌类西药临床应用的不良反应研究[J].数理医药学杂志,2016, 29(2):248-249.
[3]王晓璐,刘阳,车云秀,等.某三甲医院2015—2017年抗菌类西药临床应用不良反应探究[J].临床军医杂志,2017,45(8):776-778.
[4]池善留.265例抗菌药物致不良反应报告[J].中国医院用药评价与分析,2016, 16(10):1412-1415.
[5]杨亚蕾.临床应用抗菌药物的不良反应观察[J].中国继续医学教育,2017,9(9):201-203.
[6]完晓建,杜洪玲.不合理使用抗菌药物致不良反应的原因分析[J].中国药物经济学, 2016,11(5):24-25.
[7]乐可佳,钟晗,施芳红.112例抗菌药物不良反应分析[J].医药导报,2016,35(s1):169-171.
[8]郑丽娜,李云霞,吴静.抗菌药物不良反应分析[J].中华医院感染学杂志,2016, 26(10):2378-2380.
[9]吕长淮. 159例氟喹诺酮类抗菌药物不良反应调查[J].中国医院用药评价与分析, 2016, 16(4):551-553.
[10]刘磊,岳彬.我院2012~2014年抗菌药物不良反应分布及相关因素分析[J].西南国防医药,2015,25(11):1219-1221.