妊娠期甲状腺过氧化物酶抗体与甲状腺功能变化的分析
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摘要
目的 探究妊娠期甲状腺过氧化物酶抗体与甲状腺功能的变化并对其分析。方法 选取2015年1月—2017年12月期间在该院进行甲状腺功能检查的妊娠期女性120例,根据TPO抗体的阴阳性状态将孕妇分为参照组(TPO抗体阴性)与研究组(TPO抗体阳性),观察并对比两组孕妇在妊娠期期间其甲状腺激素与游离甲状腺素的变化。结果 通过对两组孕妇的甲状腺功能变化情况进行回顾性分析可知,研究组孕妇的甲状腺疾病的发病率(40.00%)明显高于参照组(6.70%),差异有统计学意义(χ~2=18.63,P<0.05);且研究组孕妇亚临床甲亢发病人数随孕期的增加而增长,差异有统计学意义(χ~2=8.17,P<0.05)。结论 妊娠期进行甲状腺过氧化物酶抗体检测,能够起到防治亚临床甲亢的效果,对孕期妇女具有重要的意义。
Objective To explore the changes of thyroid peroxidase antibody and thyroid function during pregnancy and analyze them.Methods A total of 120 pregnant women who underwent thyroid function examination in our hospital from January 2015 to December2017 were selected. According to the negative and positive status of TPO antibody, pregnant women were divided into control group(TPO antibody negative) and research group(TPO antibody positive). The changes of thyroid hormone and free thyroxine were ob-served and compared between the two groups during pregnancy. Results By retrospective analysis of thyroid function changes in the two groups of pregnant women, the incidence of thyroid disease in pregnant women in the study group(40.00%) was significantly high-er than the reference group(6.70%), the difference was statistically significant(χ~2=18.63, P<0.05); and the number of subclinical hyperthyroidism in the study group increased with the increase of pregnancy, the difference was statistically significant( χ~2=8.17, P<0.05).Conclusion Thyroperoxidase antibody detection during pregnancy can play a role in the prevention and treatment of subclinical hyper-thyroidism, and has important significance for pregnant women.
Objective To explore the changes of thyroid peroxidase antibody and thyroid function during pregnancy and analyze them.Methods A total of 120 pregnant women who underwent thyroid function examination in our hospital from January 2015 to December2017 were selected. According to the negative and positive status of TPO antibody, pregnant women were divided into control group(TPO antibody negative) and research group(TPO antibody positive). The changes of thyroid hormone and free thyroxine were ob-served and compared between the two groups during pregnancy. Results By retrospective analysis of thyroid function changes in the two groups of pregnant women, the incidence of thyroid disease in pregnant women in the study group(40.00%) was significantly high-er than the reference group(6.70%), the difference was statistically significant(χ~2=18.63, P<0.05); and the number of subclinical hyperthyroidism in the study group increased with the increase of pregnancy, the difference was statistically significant( χ~2=8.17, P<0.05).Conclusion Thyroperoxidase antibody detection during pregnancy can play a role in the prevention and treatment of subclinical hyper-thyroidism, and has important significance for pregnant women.
引文
[1]张晓洁,张立涛,黎青,等.南京地区中晚期妊娠妇女甲状腺激素参考值范围的初步调查及甲状腺功能分析[J].国际检验医学杂志,2018,39(23):2884-2888.
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[7]赵丽杰,郭飒,田兴芳,等.L-T4替代治疗对妊娠期亚临床甲状腺功能减退孕妇血清抵抗素、同型半胱氨酸的影响[J].中国现代医学杂志,2018,28(30):62-66.
[8]Negro R,Formoso G,Mangieri T,et al.Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroiddisease:effects on obstetrical complications[J].J Clin En-docrinol Metab,2006,91(7):2587-2591.
[9]李芳芹,冯艳涛.血清TSH,TH水平在妊娠早期的变化分析[J].现代检验医学杂志,2014,29(5):147-148,151.
[10]Lin L,Zhang XL,Long Y.Analysis of thyroid peroxidaseant ibody in early pregnancy[J].Genet Mol Res,2014,13(3):5107-5114.
[2]王岩萍.甲状腺功能减退对妊娠糖尿病发病率及妊娠结局的影响[J/OL].河南医学研究,2018(21):1.20181212.0936.030.html.
[3]白雪利,肖雪梅.探究促甲状腺激素水平与妊娠期代谢综合征的关系[J].中国医药指南,2018,16(34):30-31.
[4]王艳,李阳,查文慧,等.妊娠期甲状腺功能减退症与妊娠期高血压疾病相关性研究进展[J].中国实验诊断学,2018,22(11):2038-2040.
[5]陈荣.探究甲状腺功能检测在妊娠妇女中的应用效果[J].世界最新医学信息文摘,2018,18(92):133-134.
[6]李丽.不同妊娠期孕妇甲状腺激素水平的变化情况探究[J].中外医学研究,2018,16(32):52-53.
[7]赵丽杰,郭飒,田兴芳,等.L-T4替代治疗对妊娠期亚临床甲状腺功能减退孕妇血清抵抗素、同型半胱氨酸的影响[J].中国现代医学杂志,2018,28(30):62-66.
[8]Negro R,Formoso G,Mangieri T,et al.Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroiddisease:effects on obstetrical complications[J].J Clin En-docrinol Metab,2006,91(7):2587-2591.
[9]李芳芹,冯艳涛.血清TSH,TH水平在妊娠早期的变化分析[J].现代检验医学杂志,2014,29(5):147-148,151.
[10]Lin L,Zhang XL,Long Y.Analysis of thyroid peroxidaseant ibody in early pregnancy[J].Genet Mol Res,2014,13(3):5107-5114.