腹腔镜下卵巢打孔术对难治性多囊卵巢综合征患者激素水平变化及妊娠率的影响
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摘要
目的研究腹腔镜下卵巢打孔术(LOD)对难治性多囊卵巢综合征(PCOS)患者血清相关性激素水平变化及妊娠率的影响。方法选取2015年5月至2016年7月我院76例难治性PCOS患者作为研究对象,按术式不同分组,各38例。对照组采用阴道下卵泡穿刺术治疗,观察组采用LOD治疗。对比两组血清相关性激素水平[黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、睾酮(T)]及随访1年后妊娠率。结果两组治疗前LH、FSH、E2、T水平比较,差异无统计学意义(P>0.05);观察组治疗后LH、T水平低于对照组,差异有统计学意义(P<0.05);观察组妊娠率60.53%高于对照组36.84%,差异具有统计学意义(P<0.05)。结论 PCOS患者采用LOD治疗,可提高妊娠率,改善相关血清指标。
Objective To investigate the effect of laparoscopic ovarian drilling(LOD)on serum hormone levels and pregnancy rate in patients with refractory polycystic ovary syndrome(PCOS).Methods From May 2015 to July 2016,76 patients with refractory PCOS in our hospital were selected as study subjects,and were divided into different groups according to the operation type,with 38 cases in each group.The control group was treated by vaginal follicular puncture and the observation group was treated by LOD.Serum levels of related sex hormones(LH,FSH,E2,and T)were compared between two groups and the pregnancy rate after one year of follow-up.Results There was no significant difference in the levels of LH,FSH,E2 and T between the two groups before treatment(P>0.05).The levels of LH and T in the observation group were lower than those in the control group(P<0.05).The pregnancy rate of observation group was 60.53% higher than 36.84%of control group,the difference was statistically significant(P<0.05).Conclusions PCOS patients treated with LOD can improve the pregnancy rate and improve the relevant serum indexes.
Objective To investigate the effect of laparoscopic ovarian drilling(LOD)on serum hormone levels and pregnancy rate in patients with refractory polycystic ovary syndrome(PCOS).Methods From May 2015 to July 2016,76 patients with refractory PCOS in our hospital were selected as study subjects,and were divided into different groups according to the operation type,with 38 cases in each group.The control group was treated by vaginal follicular puncture and the observation group was treated by LOD.Serum levels of related sex hormones(LH,FSH,E2,and T)were compared between two groups and the pregnancy rate after one year of follow-up.Results There was no significant difference in the levels of LH,FSH,E2 and T between the two groups before treatment(P>0.05).The levels of LH and T in the observation group were lower than those in the control group(P<0.05).The pregnancy rate of observation group was 60.53% higher than 36.84%of control group,the difference was statistically significant(P<0.05).Conclusions PCOS patients treated with LOD can improve the pregnancy rate and improve the relevant serum indexes.
引文
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[2]薛娟,冯艳,白彩云,等.难治性多囊卵巢综合征患者采用腹腔镜下卵巢打孔术治疗临床应用价值探讨[J].中国性科学,2017,26(3):123-126.
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[4]徐姬妹.腹腔镜下卵巢打孔术联合克罗米芬对难治性多囊卵巢综合征不孕患者的治疗效果评价[J].中国妇幼保健,2016,31(18):3 799-3 801.
[5]蒋琼,张梅.腹腔镜下卵巢打孔术治疗难治性多囊卵巢综合征临床观察[J].海南医学,2016,27(3):475-477.