血清NGF、MT-1E水平变化与乳腺癌病理学特征的关系
摘要
目的探讨血清神经生长因子(NGF)、金属硫蛋白1E(MT-1E)水平变化与乳腺癌病理学特征的关系。方法选取乳腺癌90例(乳腺癌组)、乳腺良性疾病90例(良性组),ELISA法检测血清NGF、MT-1E,并根据肿瘤直径、组织学分级、TNM分期、淋巴结转移情况进行分层比较。结果乳腺癌组血清NGF、MT-1E水平均高于良性组(P均<0. 05)。乳腺癌组不同组织学分级、TNM分期、肿瘤直径及是否发生淋巴结转移患者血清NGF水平比较,差异均无统计学意义;乳腺癌组组织学分级G3级、TNM分期Ⅲ期、发生淋巴结转移患者血清MT-1E水平高于组织学分级G1+G2级、TNM分期Ⅰ期+Ⅱ期、未发生淋巴结转移者(P均<0. 05),不同肿瘤直径患者血清MT-1E水平差异无统计学意义。结论乳腺癌患者血清NGF、MT-1E水平升高,MT-1E与乳腺癌恶性程度增加有关;二者在乳腺癌的发生、发展中起重要作用。
引文
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[3]王华,高宇哲,魏娜,等.乳腺癌患者血清中金属硫蛋白-1E的表达及意义[J].广东医学,2018,39(9):1385-1388.
[4]刘凤娟,仝进毅.神经生长因子和血管内皮生长因子在上皮性卵巢癌中表达及意义研究[J].中国实用妇科与产科杂志,2017,33(9):985-987.
[5]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2015版)[J].中国癌症杂志,2015,25(9):692-754.
[6]Seidman AD,Bordeleau L,Fehrenbacher L,et al. National cancer institute breast cancer steering committee working group report on meaningful and appropriate end points for clinical trials in metastatic breast cancer[J]. J Clin Oncol,2018,36(8):228-242.
[7]Pundavela J,Roselli S,Faulkner S,et al. Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer[J].Mol Oncol,2015,9(8):1626-1635.
[8]魏西军,王清路,李俏俏,等.金属硫蛋白2A基因沉默对乳腺癌细胞Cpy6B2表达的影响[J].山东医药,2015,55(14):19-21.
[9]王华,高宇哲,魏娜,等.金属硫蛋白-2A在乳腺癌中的表达及临床意义[J].中华实验外科杂志,2017,34(12):2276.
[10]Tomellini E,Touil Y,Lagadec C,et al. Nerve growth factor and prongf simultaneously promote symmetric self-renewal,quiescence,and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment[J]. Stem Cells,2015,33(2):342-353.
[11]何伟明,吴庆金,何玉清.女性肿瘤标志物联合检测的研究现状及其应用前景[J].中国肿瘤生物治疗杂志,2018,25(2):192-197.
[12]黄小彦,池瑞霞,刘铭,等.几种三阴性乳腺癌标志物的临床病理意义[J].中华病理学杂志,2017,46(1):2-8.
[13]刘宇,王君,邹黎黎.神经生长因子及其受体作为乳腺恶性肿瘤分子标记物的可行性[J].海南医学,2017,28(3):443-446.
[14]张季,李杨,杨思原,等.乳腺癌患者血清神经生长因子和低亲和力受体p75表达水平的变化及其意义[J].中国普通外科杂志,2017,26(11):1498-1501.
[15]张美玲,董恒进.乳腺癌基因分型与血清肿瘤标志物表达的相关性分析[J].中国现代应用药学,2017,34(1):111-115.