三种CKD-EPI公式对膜性肾病患者肾小球滤过率评估的一致性评价
|
摘要
分析不同公式估算的膜性肾病患者肾小球滤过率(GFR)与肾动态GFR的一致性。通过检测膜性肾病患者血清肌酐(Scr)及胱抑素C(Cys-C)水平,评估三种公式估算的GFR与肾动态GFR一致性。三种公式对于不同性别估算的GFR值之间差异有统计学意义,CKD-EPI_(2012Scr-Cys-C)估算的GFR值显著高于CKD-EPI_(2009Scr)和CKDEPI_(2012Cys-C);三种CKD-EPI公式估算的GFR与肾动态GFR均具有相关性(P均<0. 05),CKD-EPI_(2012Scr-Cys-C)公式估算的GFR与肾动态GFR相关性较强,CKD-EPI_(2012Cys-C)公式次之,CKD-EPI_(2009Scr)公式最弱。CKD-EPI_(2012Scr-Cys-C)公式计算的GFR与肾动态GFR一致性优于CKD-EPI_(2009Scr)公式和CKD-EPI_(2012Cys-C)公式。CKD-EPI_(2012Scr-Cys-C)公式用于膜性肾病肾功能估算,与肾动态GFR具有更好的相关性和一致性。
To study the consistency of glomerular filtration rate estimated by three CKD-EPI formulas and renal dynamic GFR in patients with membranous nephropathy. The consistency of three formulas were evaluated by measuring the level of serum creatinine and cystatin C. The results show that three formulas for different genders,the GFR estimated by CKD-EPI_(2012Scr-Cys-C)were significantly higher than that by CKD-EPI_(2009Scr)and CKD-EPI_(2012Cys-C),the GFR estimated by three CKD-EPI formulas was correlated with the renal dynamic GFR( P even <0. 05),it shows the strongest correlation between GFR estimated by CKD-EPI_(2012Scr-Cys-C)and renal dynamic,the CKD-EPI_(2012Cys-C)formula is the second,and the CKDEPI_(2009Scr)formula is the weakest. The consistency of GFR estimated by CKD-EPI_(2012Scr-Cys-C)and renal dynamic GFR is superior to that of CKD-EPI_(2009Scr)and the CKD-EPI_(2012Cys-C). The CKD-EPI_(2012Scr-Cys-C)formula is used for the estimation of renal function in membranous nephropathy. It has a better correlation and consistency with renal dynamic GFR,and is closer to the actual situation of patients.
To study the consistency of glomerular filtration rate estimated by three CKD-EPI formulas and renal dynamic GFR in patients with membranous nephropathy. The consistency of three formulas were evaluated by measuring the level of serum creatinine and cystatin C. The results show that three formulas for different genders,the GFR estimated by CKD-EPI_(2012Scr-Cys-C)were significantly higher than that by CKD-EPI_(2009Scr)and CKD-EPI_(2012Cys-C),the GFR estimated by three CKD-EPI formulas was correlated with the renal dynamic GFR( P even <0. 05),it shows the strongest correlation between GFR estimated by CKD-EPI_(2012Scr-Cys-C)and renal dynamic,the CKD-EPI_(2012Cys-C)formula is the second,and the CKDEPI_(2009Scr)formula is the weakest. The consistency of GFR estimated by CKD-EPI_(2012Scr-Cys-C)and renal dynamic GFR is superior to that of CKD-EPI_(2009Scr)and the CKD-EPI_(2012Cys-C). The CKD-EPI_(2012Scr-Cys-C)formula is used for the estimation of renal function in membranous nephropathy. It has a better correlation and consistency with renal dynamic GFR,and is closer to the actual situation of patients.
引文
[1]章友康,李英.膜性肾病的诊断与治疗[J].中华肾病研究电子杂志,2013,2(1):5-10.
[2] MIRZA MK,KIM L,KADAMBI PV,et al. Membranous nephronpathy transplanted in the donor kidney:observations of resolving glomerulopathy in serial allograft biopsies[J]. Nephrol Dial Transplant,2014,29(12):2343-7.
[3] LEVEY AS,STEVENS LA,SCHMID CH,et al. A new equation to estimate glomerular filtration rate[J]. Ann Intern Med,2009,150(9):597-604.
[4] INKER LA,SCHMID CH,TIGHIOUART H,et al. Estimating glomerular filtration rate from serum creatinine and cystatin C[J].N Engl J Med,2012,367(1):20-9.
[5]朱玮玮,倪杰,许嵘,等.三种肾小球滤过率估算方程的适应性比较[J].海南医学,2017,28(1):96-8.
[6]国秀芝.基于血清肌酐和胱抑素C的肾小球滤过率评估方程在我国患者中的应用研究[M].北京协和医学院,2013.
[7]郑春苏,邹燕,黄湘宁,等.乳胶增强免疫透射比浊法检测胱抑素C的技术性能评价[J].中国医学装备,2012,9(6):5-8.
[6]张文,王刚,李宁忱,等.三种肾小球滤过率预测公式在肾脏肿瘤患者肾功能评估中的应用[J].微创泌尿外科杂志,2015,4(2):99-102.
[7]程莹,李宁娜,游志清,等.三种CKD-EPI公式与改良MDRD公式诊断糖尿病肾病一致性分析[J].中国全科医学,2016,19(29):3584-8.
[8]陈卉. Bland-Altman分析在临床测量方法一致性评价中的应用[J].中国卫生统计,2007,24(3):308-9,15.
[9] STEVENS LA,LEVEY AS. Measurement of kidney function[J].Med Clin North Am,2005,89(3):457-73.
[10]何平.胱抑素C的检测及临床应用[J].检验医学与临床,2013,10(8):1002-4.
[2] MIRZA MK,KIM L,KADAMBI PV,et al. Membranous nephronpathy transplanted in the donor kidney:observations of resolving glomerulopathy in serial allograft biopsies[J]. Nephrol Dial Transplant,2014,29(12):2343-7.
[3] LEVEY AS,STEVENS LA,SCHMID CH,et al. A new equation to estimate glomerular filtration rate[J]. Ann Intern Med,2009,150(9):597-604.
[4] INKER LA,SCHMID CH,TIGHIOUART H,et al. Estimating glomerular filtration rate from serum creatinine and cystatin C[J].N Engl J Med,2012,367(1):20-9.
[5]朱玮玮,倪杰,许嵘,等.三种肾小球滤过率估算方程的适应性比较[J].海南医学,2017,28(1):96-8.
[6]国秀芝.基于血清肌酐和胱抑素C的肾小球滤过率评估方程在我国患者中的应用研究[M].北京协和医学院,2013.
[7]郑春苏,邹燕,黄湘宁,等.乳胶增强免疫透射比浊法检测胱抑素C的技术性能评价[J].中国医学装备,2012,9(6):5-8.
[6]张文,王刚,李宁忱,等.三种肾小球滤过率预测公式在肾脏肿瘤患者肾功能评估中的应用[J].微创泌尿外科杂志,2015,4(2):99-102.
[7]程莹,李宁娜,游志清,等.三种CKD-EPI公式与改良MDRD公式诊断糖尿病肾病一致性分析[J].中国全科医学,2016,19(29):3584-8.
[8]陈卉. Bland-Altman分析在临床测量方法一致性评价中的应用[J].中国卫生统计,2007,24(3):308-9,15.
[9] STEVENS LA,LEVEY AS. Measurement of kidney function[J].Med Clin North Am,2005,89(3):457-73.
[10]何平.胱抑素C的检测及临床应用[J].检验医学与临床,2013,10(8):1002-4.