低剂量右美托咪定对于老年糖尿病患者的影响分析
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摘要
目的探讨低剂量右美托咪定对于老年糖尿病患者的影响分析。方法选择2016年2月-2018年11月期间在本院择期全麻下接受骨科下肢手术的老年患者82例,根据患者病史和用药情况分为糖尿病右美托咪定组(D1,n=21),非糖尿病右美托咪定组(D2,n=21),糖尿病非右美托咪定组(C1,n=20)和非糖尿病非右美托咪定组(C2,n=20)。对比4组患者术后心肌损伤相关指标、苏醒时间及术后ICU治疗时间。结果 D1组MDA、CK-MB指标水平最高,显著高于D2组、C1组和C2组,而D2组MDA、CK-MB指标水平最低,显著低于D1组、C1组和C2组,差异具有统计学意义(P<0. 05)。结果低剂量右美托咪定应用于老年糖尿病患者手术麻醉中,可有效减轻患者心肌损伤,缩短苏醒时间,改善患者预后。
Objective To investigate the effect of low-dose dexmedetomidine on elderly patients with diabetes mellitus.Methods Eighty-two elderly patients undergoing orthopaedic lower extremity surgery under general anesthesia from February 2016 to November 2018 were selected and divided into diabetic dexmedetomidine group( D1,n = 21),non-diabetic dexmedetomidine group( D2,n=21),diabetic non-dexmedetomidine group( C1,n=20) and non-diabetic non-dexmedetomidine group( C2,n=20). Relevant indexes of myocardial injury,recovery time and ICU treatment time were compared among the four groups. Results The levels of MDA and CK-MB in D1 group were the highest,significantly higher than those in D2 group,C1 group and C2 group,while those in D2 group were the lowest,significantly lower than those in D1 group,C1 group and C2 group( P<0. 05). Conclusion Low dose dexmedetomidine can effectively alleviate myocardial injury,shorten recovery time and improve prognosis of elderly patients with diabetes mellitus during operation anesthesia.
Objective To investigate the effect of low-dose dexmedetomidine on elderly patients with diabetes mellitus.Methods Eighty-two elderly patients undergoing orthopaedic lower extremity surgery under general anesthesia from February 2016 to November 2018 were selected and divided into diabetic dexmedetomidine group( D1,n = 21),non-diabetic dexmedetomidine group( D2,n=21),diabetic non-dexmedetomidine group( C1,n=20) and non-diabetic non-dexmedetomidine group( C2,n=20). Relevant indexes of myocardial injury,recovery time and ICU treatment time were compared among the four groups. Results The levels of MDA and CK-MB in D1 group were the highest,significantly higher than those in D2 group,C1 group and C2 group,while those in D2 group were the lowest,significantly lower than those in D1 group,C1 group and C2 group( P<0. 05). Conclusion Low dose dexmedetomidine can effectively alleviate myocardial injury,shorten recovery time and improve prognosis of elderly patients with diabetes mellitus during operation anesthesia.
引文
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[5]索才让杰,王云.右美托咪定对糖尿病患者非心脏手术围术期心血管事件的影响[J].中国药业,2018,27(21):58.
[6]席彪,赵玉婷,李晓红.右美托咪定在2型糖尿病患者全身麻醉中的临床应用[J].糖尿病新世界,2017,20(23):117.
[2]董发慧.右美托咪定辅助镇静对行椎管内麻醉的2型糖尿病老年患者术后睡眠状态的影响体会[J].糖尿病新世界,2017,20(23):115.
[3]王秀云,赵斌江,赵斌江,等.右美托咪定区域麻醉镇静对糖尿病老年患者术后认知功能的影响[J].中华麻醉学杂志,2017,37(11):1296.
[4]孟勤凤.右美托咪定对糖尿病患者全麻诱导期间心率变异性的影响研究[J].糖尿病新世界,2018,21(4):90.
[5]索才让杰,王云.右美托咪定对糖尿病患者非心脏手术围术期心血管事件的影响[J].中国药业,2018,27(21):58.
[6]席彪,赵玉婷,李晓红.右美托咪定在2型糖尿病患者全身麻醉中的临床应用[J].糖尿病新世界,2017,20(23):117.