前列舒通联合坦洛新治疗良性前列腺增生症的临床研究
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摘要
目的综合分析前列舒通胶囊联合坦洛新治疗良性前列腺增生症的临床治疗效果。方法选取我院2014年6月至2017年8月收治的200例良性前列腺增生症患者为研究对象,按随机对照法分为实验组(前列舒通联合坦洛新治疗组)和对照组(坦洛新治疗组),两组各100例。结果连续治疗12周后,实验组IPSS评分从治疗前的(18.5±2.41)分减少到(13.1±2.73)分(P<0.05),前列腺体积从治疗前的(46.18±3.62)下降至(29.03±3.15)(P<0.05),QOL评分从治疗前的(4.3±0.6)分下降至(2.7±0.2)分(P<0.05),最大尿流率(Qmax)从治疗前的(11.35±1.07)上升至(14.63±2.35)(P<0.05),对照组前列腺体积从治疗前的(45.74±4.12)下降至(42.18±3.95)(P>0.05)。前列舒通联合坦洛新能进一步改善IPSS评分、QOL、Qmax,并能减少前列腺体积。评分实验组不良反应发生率7%,对照组5%,两组不良反应发生率比较差异无统计学意义(P>0.05),两组均未发生尿潴留。结论前列舒通联合坦洛新治疗BPH安全有效,疗效优于单用坦洛新。
Objective To analyze clinical effect of Prostate Soothing Capsule combined with tamsulosin in treatment of benign prostatic hyperplasia comprehensively. Methods Choose 200 cases benign prostatic hyperplasia patients admitted to our hospital from June 2014 to August 2017 as study objects, divide them into experimental group(Prostate Soothing Capsule combined with tamsulosin treatment group) and control group(tamsulosin treatment group)randomly, 100 cases in each group. Results After 12 weeks of continuous treatment, IPSS scores of experimental group decreased from(18.5±2.41) before treatment to(13.1±2.73),(P<0.05), prostate volume decreased from(46.18±3.62) to(29.03±3.15),(P<0.05), QOL scores decreased from(4.3±0.6) before treatment to(2.7±0.2),(P<0.05), and maximum urinary flow rate(Qmax) decreased from(11.35±1.07) before treatment to(14.63±2.35),(P<0.05). Prostate volume in control group decreased from(45.74±4.12) before treatment to(42.18±3.95),(P>0.05). Alprostadil combined with tamsulosin can improve IPSS scores, QOL, Qmax, and reduce prostate volume further. Adverse reactions incidence was 7% in experimental group and 5% in control group. Adverse reactions incidence difference showed no statistical significance between two groups(P>0.05). No urinary retention occurred in two groups. Conclusion Alprostadil combined with tamsulosin is safe and effective in treatment of BPH, whose curative effect is better than tamsulosin only.
Objective To analyze clinical effect of Prostate Soothing Capsule combined with tamsulosin in treatment of benign prostatic hyperplasia comprehensively. Methods Choose 200 cases benign prostatic hyperplasia patients admitted to our hospital from June 2014 to August 2017 as study objects, divide them into experimental group(Prostate Soothing Capsule combined with tamsulosin treatment group) and control group(tamsulosin treatment group)randomly, 100 cases in each group. Results After 12 weeks of continuous treatment, IPSS scores of experimental group decreased from(18.5±2.41) before treatment to(13.1±2.73),(P<0.05), prostate volume decreased from(46.18±3.62) to(29.03±3.15),(P<0.05), QOL scores decreased from(4.3±0.6) before treatment to(2.7±0.2),(P<0.05), and maximum urinary flow rate(Qmax) decreased from(11.35±1.07) before treatment to(14.63±2.35),(P<0.05). Prostate volume in control group decreased from(45.74±4.12) before treatment to(42.18±3.95),(P>0.05). Alprostadil combined with tamsulosin can improve IPSS scores, QOL, Qmax, and reduce prostate volume further. Adverse reactions incidence was 7% in experimental group and 5% in control group. Adverse reactions incidence difference showed no statistical significance between two groups(P>0.05). No urinary retention occurred in two groups. Conclusion Alprostadil combined with tamsulosin is safe and effective in treatment of BPH, whose curative effect is better than tamsulosin only.
引文
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[5]窦科,狄文佳,熊伟,等.前列舒通胶囊用于前列腺增生合并慢性非细菌性前列腺炎的研究[J].现代中西医结合杂志,2011,20(9):65-66.
[6]付旭军,胡庆华,程金儒,等.前列舒通胶囊联合酚苄明治疗老年良性前列腺增生74例疗效观察[J].中国药业,2015,11(2):34-35.
[2]轩立华.前列舒通胶囊治疗湿热瘀阻型前列腺炎[J].吉林中医药,2015(9):914-917.
[3]张会波,石涛.盐酸坦索罗辛治疗中小体积BPH的疗效观察(附38例报告)[J].临床泌尿外科杂志,2008,23(12):952.
[4]杨振辉,陈祥.前列舒通胶囊联合坦洛新治疗慢性无菌性前列腺炎临床观察[J].中医临床研究,2017,9(13):114-115.
[5]窦科,狄文佳,熊伟,等.前列舒通胶囊用于前列腺增生合并慢性非细菌性前列腺炎的研究[J].现代中西医结合杂志,2011,20(9):65-66.
[6]付旭军,胡庆华,程金儒,等.前列舒通胶囊联合酚苄明治疗老年良性前列腺增生74例疗效观察[J].中国药业,2015,11(2):34-35.