慢性酒精依赖患者脑多模态磁共振研究进展
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摘要
慢性酒精依赖(chronic alcohol dependence, CAD)是一种慢性迁延、易复发且高患病率的成瘾性疾病。随着磁共振成像技术的发展和广泛应用,逐渐揭示出CAD患者脑形态差异和脑功能异常改变,对深入了解其发病机制、病理生理学基础及临床疗效评价具有重要意义。本文对CAD患者脑多模态磁共振研究进展进行综述。
Chronic alcohol dependence is an addictive disease characterized by chronic procrastination, easy recurrence and high prevalence. With the development of magnetic resonance imaging technology and its widespread application, it is found that the patients` cerebral morphological differences and brain function abnormity with CAD are significant for gaining insight of its pathogenesis, pathology and clinical curative effect evaluation. Here, we reviewed the progress of brain multimodality MRI in CAD patients.
Chronic alcohol dependence is an addictive disease characterized by chronic procrastination, easy recurrence and high prevalence. With the development of magnetic resonance imaging technology and its widespread application, it is found that the patients` cerebral morphological differences and brain function abnormity with CAD are significant for gaining insight of its pathogenesis, pathology and clinical curative effect evaluation. Here, we reviewed the progress of brain multimodality MRI in CAD patients.
引文
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[9] Clark CP, Brown GG, Eyler LT, et al. Decreased perfusion in young alcohol-dependent women as compared with age-matched controls [J]. The American Journal of Drug and Alcohol Abuse, 2007, 33(1): 13-19.
[10] Mon A, Durazzo TC, Gazdzinski S. The impact of chronic cigarette smoking on recovery from cortical gray matter perfusion deficits in alcohol dependence: longitudinal arterial spin labeling MRI [J]. Alcoholism, Clinical and Experimental Research, 2009, 33(8): 1314-1321.
[11] Rickenbacher E, Greve DN, Azma S, et al. Effects of alcohol intoxication and gender on cerebral perfusion: an arterial spin labeling study [J]. Alcohol (Fayetteville, N.Y.), 2011, 45(8): 725-737.
[12] Bauer J, Pedersen A, Scherbaum N, et al. Craving in alcohol-dependent patients after detoxification is related to glutamatergic dysfunction in the nucleus accumbens and the anterior cingulate cortex [J]. Neuropsychopharmacology, 2013, 38(3): 1401-1408.
[13] Frischknecht U, Hermann D, Tunc-Skarka N, et al. Negative association between MR-spectroscopic glutamate markers and gray matter volume after alcohol withdrawal in the hippocampus: a translational study in humans and rats [J]. Alcoholism: Clinical and Experimental Research, 2017, 41(2): 323-333.
[14] Cheng H, Kellar D, Lake A, et al. Effects of alcohol cues on MRS glutamate levels in the anterior cingulate [J]. Alcohol and Alcoholism, 2018, 53(3): 209-215.
[15] Bagga D, Khushu S, Modi S, et al. Impaired visual information processing in alcohol-dependent subjects: a proton magnetic resonance spectroscopy study of the primary visual cortex [J].Journal of Studies On Alcohol and Drugs, 2014, 75(5): 817-826.
[16] Prisciandaro JJ, Schacht JP, Prescot AP, et al. Associations between recent heavy drinking and dorsal anterior cingulate N-acetylaspartate and glutamate concentrations in non-treatment-seeking individuals with alcohol dependence [J]. Alcoholism, Clinical and Experimental Research, 2016, 40(3): 491-496.
[17] 陈乾,陈楠,李坤成.脊髓损伤后大脑网络连接变化的功能MRI研究进展[J].医学影像学杂志,2017,27(12):2399-2401.
[18] Hong JY, Müller-Oehring EM, Pfefferbaum A, et al. Aberrant blood-oxygen-level-dependent signal oscillations across frequency bands characterize the alcoholic brain [J]. Addiction Biology, 2018, 23(2): 824-835.
[2] Rando K, Hong KI, Bhagwagar Z, et al. Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study [J]. The American Journal of Psychiatry, 2011, 168(2): 183-192.
[3] Ruiz SM, Oscar-Berman M, Sawyer KS, et al. Drinking history associations with regional white matter volumes in alcoholic men and women [J]. Alcoholism, Clinical and Experimental Research, 2013, 37(1): 110-122.
[4] Alhassoon OM, Sorg SF, Taylor MJ, et al. Callosal white matter microstructural recovery in abstinent alcoholics: a longitudinal diffusion tensor imaging study [J]. Alcoholism, Clinical and Experimental Research, 2012, 36(11): 1922-1931.
[5] Monnig MA, Caprihan A, Yeo RA, et al. Diffusion tensor imaging of white matter networks in individuals with current and remitted alcohol use disorders and comorbid conditions [J]. Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors, 2013, 27(2): 455-465.
[6] Trivedi R, Bagga D, Bhattacharya D, et al. White matter damage is associated with memory decline in chronic alcoholics: a quantitative diffusion tensor tractography study [J]. Behavioural Brain Research, 2013, 250(6): 192-198.
[7] Bagga D, Sharma A, Kumari A, et al. Decreased white matter integrity in fronto-occipital fasciculus bundles: relation to visual information processing in alcohol-dependent subjects [J]. Alcohol (Fayetteville, N.Y.), 2014, 48(1): 43-53.
[8] Durazzo TC, Gazdzinski S, Mon A. Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment [J]. Alcohol (Fayetteville, N.Y.), 2010, 44(3): 201-210.
[9] Clark CP, Brown GG, Eyler LT, et al. Decreased perfusion in young alcohol-dependent women as compared with age-matched controls [J]. The American Journal of Drug and Alcohol Abuse, 2007, 33(1): 13-19.
[10] Mon A, Durazzo TC, Gazdzinski S. The impact of chronic cigarette smoking on recovery from cortical gray matter perfusion deficits in alcohol dependence: longitudinal arterial spin labeling MRI [J]. Alcoholism, Clinical and Experimental Research, 2009, 33(8): 1314-1321.
[11] Rickenbacher E, Greve DN, Azma S, et al. Effects of alcohol intoxication and gender on cerebral perfusion: an arterial spin labeling study [J]. Alcohol (Fayetteville, N.Y.), 2011, 45(8): 725-737.
[12] Bauer J, Pedersen A, Scherbaum N, et al. Craving in alcohol-dependent patients after detoxification is related to glutamatergic dysfunction in the nucleus accumbens and the anterior cingulate cortex [J]. Neuropsychopharmacology, 2013, 38(3): 1401-1408.
[13] Frischknecht U, Hermann D, Tunc-Skarka N, et al. Negative association between MR-spectroscopic glutamate markers and gray matter volume after alcohol withdrawal in the hippocampus: a translational study in humans and rats [J]. Alcoholism: Clinical and Experimental Research, 2017, 41(2): 323-333.
[14] Cheng H, Kellar D, Lake A, et al. Effects of alcohol cues on MRS glutamate levels in the anterior cingulate [J]. Alcohol and Alcoholism, 2018, 53(3): 209-215.
[15] Bagga D, Khushu S, Modi S, et al. Impaired visual information processing in alcohol-dependent subjects: a proton magnetic resonance spectroscopy study of the primary visual cortex [J].Journal of Studies On Alcohol and Drugs, 2014, 75(5): 817-826.
[16] Prisciandaro JJ, Schacht JP, Prescot AP, et al. Associations between recent heavy drinking and dorsal anterior cingulate N-acetylaspartate and glutamate concentrations in non-treatment-seeking individuals with alcohol dependence [J]. Alcoholism, Clinical and Experimental Research, 2016, 40(3): 491-496.
[17] 陈乾,陈楠,李坤成.脊髓损伤后大脑网络连接变化的功能MRI研究进展[J].医学影像学杂志,2017,27(12):2399-2401.
[18] Hong JY, Müller-Oehring EM, Pfefferbaum A, et al. Aberrant blood-oxygen-level-dependent signal oscillations across frequency bands characterize the alcoholic brain [J]. Addiction Biology, 2018, 23(2): 824-835.