腰椎脊柱推拿联合透明质酸钠治疗膝关节骨性关节炎患者的效果
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摘要
目的分析腰椎脊柱推拿联合透明质酸钠治疗膝关节骨性关节炎(KOA)患者的临床效果,及对血清S100A12、软骨寡聚基质蛋白(COMP)水平的影响。方法将2016年1月～2018年1月浙江中医药大学附属第三医院收治的100例KOA患者采用随机信封法分为观察组及对照组,各50例。对照组采用透明质酸钠治疗,观察组采用腰椎脊柱推拿联合透明质酸钠治疗。治疗后观察两组患者视觉模拟评分(VAS)、临床疗效、S100A12及COMP水平,并统计两组患者满意率。结果治疗后观察组总有效率显著高于对照组(P <0.05)。治疗后两组VAS评分均较治疗前显著降低(P <0.05),且观察组VAS评分显著低于对照组(P <0.05)。治疗后两组血中S100A12及COMP水平均显著降低(P <0.05),且观察组各指标水平显著低于对照组(P <0.05)。观察组患者满意率显著高于对照组(P <0.05)。结论采用腰椎脊柱推拿联合透明质酸钠治疗KOA患者可有效提高临床疗效和临床满意率,降低患者VAS评分和S100A12、COMP水平。
Objective To analyze the clinical efficacy of lumbar spine massage combined with Sodium Hyaluronate in the treatment of knee osteoarthritis(KOA) and its influence on serum S100 A12 and cartilage oligomeric matrix protein(COMP) levels. Methods One hundred cases of KOA patients admitted to the Third Affiliated Hospital of Zhejiang Chinese Medical University from January 2016 to January 2018 were divided into the observation group and the control group by random envelope method, with 50 cases in each group. The control group was treated with Sodium Hyaluronate,while the observation group was treated with lumbar spine massage combined with Sodium Hyaluronate. After treatment,the visual analogue scale(VAS), clinical efficacy, S100 A12 and COMP levels of the two groups were observed, and the satisfaction rates of the two groups were analyzed. Results After treatment, the total effective rate of observation group was significantly higher than that of control group(P < 0.05). After treatment, the VAS scores of the two groups were significantly lower than those before treatment(P < 0.05), and the VAS score of the observation group was significantly lower than that of control group(P < 0.05). After treatment, the levels of S100 A12 and COMP in the blood of the two groups were decreased significantly(P < 0.05), which of observation group were significantly lower than those of control group(P <0.05). The satisfaction rate of observation group was significantly higher than that of control group(P < 0.05). Conclusion The combination of lumbar spine massage and Sodium Hyaluronate in the treatment of KOA patients can improve the clinical efficacy and clinical satisfaction rate, reduce the patients′ VAS scores, S100 A12 and COMP levels.
Objective To analyze the clinical efficacy of lumbar spine massage combined with Sodium Hyaluronate in the treatment of knee osteoarthritis(KOA) and its influence on serum S100 A12 and cartilage oligomeric matrix protein(COMP) levels. Methods One hundred cases of KOA patients admitted to the Third Affiliated Hospital of Zhejiang Chinese Medical University from January 2016 to January 2018 were divided into the observation group and the control group by random envelope method, with 50 cases in each group. The control group was treated with Sodium Hyaluronate,while the observation group was treated with lumbar spine massage combined with Sodium Hyaluronate. After treatment,the visual analogue scale(VAS), clinical efficacy, S100 A12 and COMP levels of the two groups were observed, and the satisfaction rates of the two groups were analyzed. Results After treatment, the total effective rate of observation group was significantly higher than that of control group(P < 0.05). After treatment, the VAS scores of the two groups were significantly lower than those before treatment(P < 0.05), and the VAS score of the observation group was significantly lower than that of control group(P < 0.05). After treatment, the levels of S100 A12 and COMP in the blood of the two groups were decreased significantly(P < 0.05), which of observation group were significantly lower than those of control group(P <0.05). The satisfaction rate of observation group was significantly higher than that of control group(P < 0.05). Conclusion The combination of lumbar spine massage and Sodium Hyaluronate in the treatment of KOA patients can improve the clinical efficacy and clinical satisfaction rate, reduce the patients′ VAS scores, S100 A12 and COMP levels.
引文
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[17]Choi YH,Kwon SW,Moon JH,et al.Lateral Lumbar Interbody Fusion andin SituScrew Fixation for Rostral Adjacent Segment Stenosis of the Lumbar Spine[J].J Korean Neurosurg Soc,2017,60(6):755-762.
[18]刘一秀,阿良,刘哲.关节腔清理术联合透明质酸钠关节腔内注射治疗早中期膝骨关节炎的疗效分析[J].中国医科大学学报,2017,46(2):179-181.
[19]李勇超.循环肿瘤细胞通过诱导系统性炎症及调控中性粒细胞的功能促进播散肿瘤细胞转移克隆的形成[D].武汉:华中科技大学,2017.
[20]黄杰华,康明,张彦,等.膝关节骨关节炎镜下清理术后联合应用得宝松、利多卡因及玻璃酸钠的疗效分析[J].中国医药科学,2017,7(14):15-17,48.
[21]Boyadjian H,Idowu O,Mosenthal W,et al.Comparing Bleeding vs Clotting Complications after Lumbar Spine Surgery[J].Spine J,2017,17(10):S100.
[2]邵玉霞,梅轶芳,张志毅.运动疗法在膝骨关节炎治疗中的研究进展[J].中华内科杂志,2017,56(2):147-149.
[3]Tiouririne M,Dixon AJ,Jr MF,et al.Imaging Performance of a Handheld Ultrasound System With Real-Time Computer-Aided Detection of Lumbar Spine Anatomy:A Feasibility Study[J].Invest Radiol,2017,52(8):447-455.
[4]袁学峰,任珩,刘雅静,等.补肾中药联合透明质酸钠治疗膝关节骨性关节炎疗效及对超敏C反应蛋白和炎症细胞因子的影响[J].现代中西医结合杂志,2018,27(7):775-778.
[5]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994.
[6]Bousquet PJ,Combescure C,Klossek JM,et al.Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis[J].Allergy Clin Immunol,2009,123(6):1349-1354.
[7]戎露江,夏永法,钱涛,等.富含血小板血浆联合骨髓间充质干细胞治疗骨性关节炎的WOMAC评分分析[J].浙江创伤外科,2017,22(2):294-295.
[8]Lv H,Chen W,Yuwen P,et al.Multivariate analysis of factors related to radiographic knee osteoarthritis based on the comparison between football players and matched nonsportsmen[J].Int Orthop,2018,42(4):1-9.
[9]Kaloria N,Bihani P,Bhatia P,et al.A Comparison of Regional Versus General Anesthesia for Lumbar Spine Surgery:An Untouched Aspect of the Meta-Analysis[J].JNeurosurg Anesthesiol,2018,30(2):191.
[10]韩大鹏,成小燕,欧阳桂林.髌骨软化症中西医治疗进展[J].长春中医药大学学报,2017,33(3):487-489.
[11]张建光,陈路,蔚芃,等.膝骨关节炎严重程度与脊柱-骨盆矢状面平衡的相关性[J].四川医学,2017,38(5):517-520.
[12]孙振新,杨矛,朱玲玲,等.中医药治疗膝骨关节炎研究进展[J].辽宁中医药大学学报,2017,19(1):111-114.
[13]Leslie WD,Shevroja E,Johansson H,et al.Risk-equivalent T-score adjustment for using lumbar spine trabecular bone score(TBS):the Manitoba BMD registry[J].Osteoporosis Int,2018,29(6):1-8.
[14]Hansen BB,Hansen P,Christensen AF,et al.Reliability of standing weight-bearing(0.25T)MR imaging findings and positional changes in the lumbar spine[J].Skeletal Radiol,2018,47(1):25-35.
[15]Weston EB,Khan SN,Marras WS.Wheelchair pushing and turning:lumbar spine and shoulder loads and recommended limits[J].Ergonomics,2017,60(12):1-36.
[16]粟迎春,雷小俊.关节腔内注射透明质酸钠联合塞来昔布治疗早中期膝关节骨关节炎的疗效分析[J].中华关节外科杂志:电子版,2017,11(2):89-93.
[17]Choi YH,Kwon SW,Moon JH,et al.Lateral Lumbar Interbody Fusion andin SituScrew Fixation for Rostral Adjacent Segment Stenosis of the Lumbar Spine[J].J Korean Neurosurg Soc,2017,60(6):755-762.
[18]刘一秀,阿良,刘哲.关节腔清理术联合透明质酸钠关节腔内注射治疗早中期膝骨关节炎的疗效分析[J].中国医科大学学报,2017,46(2):179-181.
[19]李勇超.循环肿瘤细胞通过诱导系统性炎症及调控中性粒细胞的功能促进播散肿瘤细胞转移克隆的形成[D].武汉:华中科技大学,2017.
[20]黄杰华,康明,张彦,等.膝关节骨关节炎镜下清理术后联合应用得宝松、利多卡因及玻璃酸钠的疗效分析[J].中国医药科学,2017,7(14):15-17,48.
[21]Boyadjian H,Idowu O,Mosenthal W,et al.Comparing Bleeding vs Clotting Complications after Lumbar Spine Surgery[J].Spine J,2017,17(10):S100.