微生物多糖透明质酸生物医用水凝胶研究
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摘要
微生物多糖透明质酸水凝胶作为具有多样生物活性非人工合成高分子材料,因其在药物缓释、组织修复等领域的出色性能,近年已成为天然生物医用材料研究热点之一。但透明质酸水凝胶尚存在降解时间较短、力学性能不佳等缺陷,而无法实现对不同类型组织的良好修复。因此,为赋予透明质酸更优材料应用性能及生物功能,以透明质酸为原料制备具有卓越力学性能、适当降解速率的水凝胶研究具有重要理论和实践意义。本文从生物医用角度对近年采用化学交联及物理作用制备改性透明质酸水凝胶的研究进行综述,提出用于组织工程领域透明质酸水凝胶医用材料未来发展中亟待解决的问题,进而为透明质酸水凝胶应用研究提供有价值的参考。
引文
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[9] FAKHARI A,BERKLAND C.Applications and emerging trends of hyaluronic acid in tissue engineering,as a dermal filler and in osteoarthritis treatment [J].Acta Biomater,2013,9(7):7081-7092.
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[18] PARK K M,YANG J A,JUNG H,et al.In situ supramolecular assembly and modular modification of hyaluronic acid hydrogels for 3D cellular engineering [J].Acs Nano,2012,6(4):2960.
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[27] YAN X,YANG X,TONG X,et al.A method to accelerate the gelation of disulfide-crosslinked hydrogels [J].Chin J Polymer Sci,2015,33(1):118-127.
[28] ZHANG Y,ROSSI F,PAPA S,et al.Non-invasive in vitro and in vivo monitoring of degradation of fluorescently labeled hyaluronan hydrogels for tissue engineering applications [J].Acta Biomater,2016,30:188-198.
[29] FUKUOKA T,UYAMA H,KOBAYASHI S.Polymerization of polyfunctional macromolecules:synthesis of a new class of high molecular weight poly(amino acid)s by oxidative coupling of phenol-containing precursor polymers[J].Biomacromolecules,2004,5(3):977.
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[33] TAVSANLI B,OKAY O.Mechanically strong hyaluronic acid hydrogels with an interpenetrating network structure [J].Eur Polym J,2017,94:175-189.
[34] KHEIRABADI M,SHI L,BAGHERI R,et al.In situ forming interpenetrating hydrogels of hyaluronic acid hybridized with iron oxide nanoparticles [J].Biomater Sci,2015,3(11):1466-1474.
[35] ZHANG Y,HEHER P,HILBORN J,et al.Hyaluronic acid-fibrin interpenetrating double network hydrogel prepared in situ by orthogonal disulfide cross-linking reaction for biomedical applications [J].Acta Biomaterialia,2016,38:23-32.
[36] OLDINSKI R A,RUCKH T T,STAIGER M P,et al.Dynamic mechanical analysis and biomineralization of hyaluronan-polyethylene copolymers for potential use in osteochondral defect repair [J].Acta Biomater,2011,7(3):1184-1191.
[37] PéREZ-GARNES M,MONLE N-PRADAS M.Poly(methacrylated hyaluronan- co -ethyl acrylate) copolymer networks with tunable properties and enzymatic degradation [J].Polym Degradation Stability,2017,144:241-250.
[38] D′ESTE M,ALINI M,EGLIN D.Single step synthesis and characterization of thermoresponsive hyaluronan hydrogels [J].Carbohydr Polym,2012,90(3):1378-1385.
[39] PEREIRA C L,GON ALVES R M,PEROGLIO M,et al.The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs [J].Biomaterials,2014,35(28):8144-8153.
[40] PARK S H,CUI J H,PARK S R,et al.Potential of fortified fibrin/hyaluronic acid composite gel as a cell delivery vehicle for chondrocytes [J].Artif Organs,2010,33(6):439-447.
[41] ZHU D,WANG H,TRINH P,et al.Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration [J].Biomaterials,2017,127:132-140.
[42] PUPERI D S,O’CONNELL R W,PUNSKE Z E,et al.Hyaluronan Hydrogels for a biomimetic spongiosa layer of tissue engineered heart valve scaffolds [J].Biomacromolecules,2016,17(5):1766.
[43] KUO Y C,CHEN Y C.Regeneration of neurite-like cells from induced pluripotent stem cells in self-assembled hyaluronic acid-gelatin microhydrogel [J].J Taiwan Inst Chem Eng,2016,67:74-87
[2] SELIKTAR D.Designing cell-compatible hydrogels for biomedical applications [J].Science,2012,336(6085):1124-1128.
[3] SNCHEZ-TLLEZ D A,TLLEZ-JURADO L,RODR GUEZ-LORENZO L M.Hydrogels for cartilage regeneration,from polysaccharides to hybrids [J].Polymers,2017,9(12):671.
[4] DRURY J L,MOONEY D J.Hydrogels for tissue engineering:scaffold design variables and applications [J].Biomaterials,2003,24(24):4337-4351.
[5] KNIPE J M,PEPPAS N A.Multi-responsive hydrogels for drug delivery and tissue engineering applications [J].Regen Biomateri,2014,1(1):57-65.
[6] ZHANG Y R,TANG L Q,XIE B X,et al.A variable mass meso-model for the mechanical and water-expelled behaviors of pva hydrogel in compression [J].Int J Appl Mech,2017,9(3):1750044.
[7] FISHER J P,VEHOF J W,DEAN D,et al.Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model [J].J Biomed Mater Res,2002,59(3):547-556.
[8] HOWARD D,PARTRIDGE K,YANG X,et al.Immunoselection and adenoviral genetic modulation of human osteoprogenitors:in vivo bone formation on PLA scaffold [J].Biochem Biophys Res Commun,2002,299(2):208-215.
[9] FAKHARI A,BERKLAND C.Applications and emerging trends of hyaluronic acid in tissue engineering,as a dermal filler and in osteoarthritis treatment [J].Acta Biomater,2013,9(7):7081-7092.
[10] GNAVI S,DI B L,TONDATURO C,et al.Gelatin-based hydrogel for vascular endothelial growth factor release in peripheral nerve tissue engineering [J].J Tissue Eng Regen Med,2017,11(2):459-470.
[11] PARK H,LEE H J,AN H,et al.Alginate hydrogels modified with low molecular weight hyaluronate for cartilage regeneration [J].Carbohydr Polymers,2017,162:100-107.
[12] NADERI-MESHKIN H,ANDREAS K,MATIN M M,et al.Chitosan-based injectable hydrogel as a promising in situ forming scaffold for cartilage tissue engineering [J].Cell Biol Int,2013,38(1):72-84.
[13] FRASER J R,LAURENT T C,LAURENT U B.Hyaluronan:its nature,distribution,functions and turnover [J].J Int Med,2010,242(1):27-33.
[14] BURDICK J A,PRESTWICH G D.Hyaluronic acid hydrogels for biomedical applications [J].Adv Mater,2011,23(12):H41-H56.
[15] LAURENT T C,FRASER J R.The properties and turnover of hyaluronan [J].Ciba Found Symp,1986,124(1):9.
[16] BALAZS E A.The role of hyaluronan in the structure and function of the biomatrix of connective tissues [J].Struct Chem,2009,20(2):233-243.
[17] NING C,QIAN J,LIU T,et al.Hyaluronic acid hydrogel scaffolds with a triple degradation behavior for bone tissue engineering [J].Carbohydr Polymers,2015,126:192-198.
[18] PARK K M,YANG J A,JUNG H,et al.In situ supramolecular assembly and modular modification of hyaluronic acid hydrogels for 3D cellular engineering [J].Acs Nano,2012,6(4):2960.
[19] LEACH J B,BIVENS K A,JR C W P,et al.Photocrosslinked hyaluronic acid hydrogels:Natural,biodegradable tissue engineering scaffolds [J].Biotechnol Bioeng,2003,82(5):578-589.
[20] WENG L,GOULDSTONE A,WU Y,et al.Mechanically strong double network photocrosslinked hydrogels from N,N-dimethylacrylamide and glycidyl methacrylated hyaluronan[J].Biomaterials,2008,29(14):2153-2163.
[21] FENN S L,OLDINSKI R A.Visible light crosslinking of methacrylated hyaluronan hydrogels for injectable tissue repair [J].J Biomed Mater Res,2016,104(6):1229-1236.
[22] NAIR S,REMYA N S,REMYA S,et al.A biodegradable in situ injectable hydrogel based on chitosan and oxidized hyaluronic acid for tissue engineering applications [J].Carbohydr Polymers,2011,85(4):838-844.
[23] NEETHU M,MOHANAN P V,SABAREESWARAN A,et al.Chitosan-hyaluronic acid hydrogel for cartilage repair[J].Int J Biol Macromol,2017,104:1936-1945.
[24] HOZUMI T,KAGEYAMA T,OHTA S,et al.Injectable hydrogel with slow degradability composed of gelatin and hyaluronic acid crosslinked by schiff’s base formation [J].Biomacromolecules,2018,19(2):288-297.
[25] FEDERICO S,N?CHEL U,L?WENBERG C,et al.Supramolecular hydrogel networks formed by molecular recognition of collagen and a peptide grafted to hyaluronic acid [J].Acta Biomater,2016,38:1-10.
[26] LI Q,WILLIAMS C G,SUN D D,et al.Photocrosslinkable polysaccharides based on chondroitin sulfate [J].J Biomed Mater Res,2010,68A(1):28-33.
[27] YAN X,YANG X,TONG X,et al.A method to accelerate the gelation of disulfide-crosslinked hydrogels [J].Chin J Polymer Sci,2015,33(1):118-127.
[28] ZHANG Y,ROSSI F,PAPA S,et al.Non-invasive in vitro and in vivo monitoring of degradation of fluorescently labeled hyaluronan hydrogels for tissue engineering applications [J].Acta Biomater,2016,30:188-198.
[29] FUKUOKA T,UYAMA H,KOBAYASHI S.Polymerization of polyfunctional macromolecules:synthesis of a new class of high molecular weight poly(amino acid)s by oxidative coupling of phenol-containing precursor polymers[J].Biomacromolecules,2004,5(3):977.
[30] LEE F,CHUNG J E,KURISAWA M.An injectable enzymatically crosslinked hyaluronic acid-tyramine hydrogel system with independent tuning of mechanical strength and gelation rate [J].Soft Matter,2008,4(4):880-887.
[31] LEE F,CHUNG J E,KURISAWA M.An injectable hyaluronic acid-tyramine hydrogel system for protein delivery [J].J Control Release,2009,134(3):186-193.
[32] KUCERA L,WEINFURTEROVá R,DVORáKOVA J,et al.Chondrocyte cultivation in hyaluronan-tyramine cross-linked hydrogel [J].Int J Polym Mater Polym Biomater,2015,64(13):661-674.
[33] TAVSANLI B,OKAY O.Mechanically strong hyaluronic acid hydrogels with an interpenetrating network structure [J].Eur Polym J,2017,94:175-189.
[34] KHEIRABADI M,SHI L,BAGHERI R,et al.In situ forming interpenetrating hydrogels of hyaluronic acid hybridized with iron oxide nanoparticles [J].Biomater Sci,2015,3(11):1466-1474.
[35] ZHANG Y,HEHER P,HILBORN J,et al.Hyaluronic acid-fibrin interpenetrating double network hydrogel prepared in situ by orthogonal disulfide cross-linking reaction for biomedical applications [J].Acta Biomaterialia,2016,38:23-32.
[36] OLDINSKI R A,RUCKH T T,STAIGER M P,et al.Dynamic mechanical analysis and biomineralization of hyaluronan-polyethylene copolymers for potential use in osteochondral defect repair [J].Acta Biomater,2011,7(3):1184-1191.
[37] PéREZ-GARNES M,MONLE N-PRADAS M.Poly(methacrylated hyaluronan- co -ethyl acrylate) copolymer networks with tunable properties and enzymatic degradation [J].Polym Degradation Stability,2017,144:241-250.
[38] D′ESTE M,ALINI M,EGLIN D.Single step synthesis and characterization of thermoresponsive hyaluronan hydrogels [J].Carbohydr Polym,2012,90(3):1378-1385.
[39] PEREIRA C L,GON ALVES R M,PEROGLIO M,et al.The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs [J].Biomaterials,2014,35(28):8144-8153.
[40] PARK S H,CUI J H,PARK S R,et al.Potential of fortified fibrin/hyaluronic acid composite gel as a cell delivery vehicle for chondrocytes [J].Artif Organs,2010,33(6):439-447.
[41] ZHU D,WANG H,TRINH P,et al.Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration [J].Biomaterials,2017,127:132-140.
[42] PUPERI D S,O’CONNELL R W,PUNSKE Z E,et al.Hyaluronan Hydrogels for a biomimetic spongiosa layer of tissue engineered heart valve scaffolds [J].Biomacromolecules,2016,17(5):1766.
[43] KUO Y C,CHEN Y C.Regeneration of neurite-like cells from induced pluripotent stem cells in self-assembled hyaluronic acid-gelatin microhydrogel [J].J Taiwan Inst Chem Eng,2016,67:74-87