脂肪源性干细胞联合透明质酸在皮肤年轻化中的疗效观察
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摘要
目的:探讨自体脂肪源性干细胞联合透明质酸在面部年轻化中的应用效果。方法:将收治的40例面部年轻化就医者,随机分为实验组和对照组,每组20例。实验组行水光注射脂肪源性干细胞联合透明质酸治疗,对照组水光注射透明质酸。结合VISIA检测评估面部情况,比较患者治疗前后的斑点、毛孔、皱纹、皮肤纹理及紫外线色斑情况。结果:治疗后,实验组在斑点、皱纹、皮肤纹理及紫外线色斑等方面的改善幅度与对照组比较,差异有统计学意义(P<0.05)。结论:脂肪源性干细胞联合透明质酸能更好地改善老化皮肤,随着技术的不断发展以及经验积累,其在面部年轻化方面将有更大的应用空间。
Objective To investigate the effect of adipose-derived stem cells combined with hyaluronic acid in facial rejuvenation. Methods 40 cases of facial rejuvenation were randomly divided into the experimental group and the control group, 20 cases in each group. The experimental group was injected with adipose-derived stem cells combined with hyaluronic acid by water injection. The control group was injected with hyaluronic acid. Face condition was assessed by VISIA, and the scores of spots, pores, wrinkles, skin textures and ultraviolet spots were compared before and after treatment. Results After treatment, the improvement range of spots, wrinkles, skin texture and ultraviolet spots in the experimental group were significantly different from those in the control group, the differences were statistically significant(P<0.05). Conclusion Adipose-derived stem cells combined with hyaluronic acid can better improve the aging skin. With the development of technology and the accumulation of experience, it will have a greater application space in facial rejuvenation.
Objective To investigate the effect of adipose-derived stem cells combined with hyaluronic acid in facial rejuvenation. Methods 40 cases of facial rejuvenation were randomly divided into the experimental group and the control group, 20 cases in each group. The experimental group was injected with adipose-derived stem cells combined with hyaluronic acid by water injection. The control group was injected with hyaluronic acid. Face condition was assessed by VISIA, and the scores of spots, pores, wrinkles, skin textures and ultraviolet spots were compared before and after treatment. Results After treatment, the improvement range of spots, wrinkles, skin texture and ultraviolet spots in the experimental group were significantly different from those in the control group, the differences were statistically significant(P<0.05). Conclusion Adipose-derived stem cells combined with hyaluronic acid can better improve the aging skin. With the development of technology and the accumulation of experience, it will have a greater application space in facial rejuvenation.
引文
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[14]Kim WS,Park BS,Kim HK,et a1.Evidence supposing antioxidant action of adipose-derived stem cells:protection of human dermal fi broblasts from oxidative stress[J].J Dermatol Sci,2008,49(2):133-142.
[15]Li X,Zhao H,Qi C,et al.Direct intercellular communicationsdominate the interaction between adipose-derived MSCs and my-ofi broblasts against cardiac fi brosis[J].Protein Cell,2015,6(10):735-745.
[16]高国珍.面部整形美容中自体脂肪源性干细胞应用价值研究[J].世界最新医学信息文摘,2018,18(20):10-11.
[2]张歌,暴志国,王琰,等.水光注射技术在面部年轻化当中的应用[J].中国医疗美容,2014,4(5):113.
[3]Zuk PA,Zhu M,Mizuno H,et al.Multilineage cells from human adipose tissue:implications for cell-based therapies[J].Tissue Eng,2001,7(2):211-228.
[4]Tan SS,Ng ZY,Zhan W,et al.Role of Adipose-derived stem cells in fat grafting and reconstructive surgery[J].J Cutan Aesthet Surg,2016,9(3):152-156.
[5]郭恩琪,谢庆平,朱孜冠.严重复合组织缺损皮瓣修复术后应用自体脂肪干细胞构建组织工程重建骨支架[J].中华显微外科杂志,2017,40(3):213-217.
[6]Frese L,Dijkman PE,Hoerstrup SP.Adipose tissue-derived stem cells in regenerative medicine[J].Transfus Med Hemother,2016,43(4):268-274.
[7]郭吉安,余丕军,王露萍,等.脂肪干细胞旁分泌功能在面部抗衰老领域的研究应用与进展[J].中国组织工程研究,2017,21(5):789-794.
[8]中华医学会皮肤性病学分会皮肤激光医疗美容学组,中国医师协会美容与整形医师分会.激光亚专委会电子注射(水光疗法)专家共识[J].实用皮肤病学杂志,2018,11(2):65-66.
[9]吴溯帆.透明质酸的基本知识和临床应用[J].现代实用医学,2010,22(4):363-364.
[10]赵依,戴杏,胡英姿,等.微针导入含透明质酸钠的复合溶液在面部年轻化中的应用[J].中国美容医学,2018,27(3):56-60.
[11]王婧薷,刘宏伟,付小兵.几种再生医学技术在面部年轻化治疗中的应用[J].中国美容整形外科杂志,2015,26(7):421-423.
[12]隋冰,王微,李春阳,等.脂肪干细胞降低光老化皮肤黑色素含量的实验研究[J].中国美容医学,2017,26(6):79-81.
[13]Pandel R,Polj?ak B,Godic A,et a1.Skin photoaging and the role of antioxidants in its prevention[J].ISRN Dermatol,2013,2013:930164.
[14]Kim WS,Park BS,Kim HK,et a1.Evidence supposing antioxidant action of adipose-derived stem cells:protection of human dermal fi broblasts from oxidative stress[J].J Dermatol Sci,2008,49(2):133-142.
[15]Li X,Zhao H,Qi C,et al.Direct intercellular communicationsdominate the interaction between adipose-derived MSCs and my-ofi broblasts against cardiac fi brosis[J].Protein Cell,2015,6(10):735-745.
[16]高国珍.面部整形美容中自体脂肪源性干细胞应用价值研究[J].世界最新医学信息文摘,2018,18(20):10-11.