前庭阵发症的临床研究进展
摘要
前庭阵发症(VP)是发作性外周前庭疾病的一种,其反复发作严重影响病人的生活质量。1994年Brandt和Dieterich首次引入了前庭阵发症这一术语。主要表现为反复发作的旋转性或非旋转性眩晕,发作持续数秒至数分钟,发作时间短暂,发作频繁,目前认为少突胶质细胞覆盖的第Ⅷ脑神经近端部分受到血管为主的邻近组织的压迫而导致的假突触放电是VP的神经学基础。MRI成像显示第Ⅷ脑神经的神经血管压迫,治疗上以卡马西平、奥卡西平均有效,内科治疗无效时可行微血管减压术。
引文
[1] JANNETTA P J.Neurovascular cross-compression in patients with hyperactive dysfunction symptoms of the eighth cranial nerve[J].Surg Forum,1975,26(47):467-469.
[2] JANNETTA P J,MARGARETA B,AAGE R.Disabling positional vertigo[J].New England Journal of Medicine,1984,310(26):1700-1705.
[3] MOLLER M B,MOLLER A R,JANNETTA P J,et al.Diagnosis and surgical treatment of disabling positional vertigo[J].Journal of Neurosurgery,1986,64(1):21-28.
[4] BRANDT T,DIETERICH M .Vestibular paroxysmia:vascular compression of the eighth nerve?[J].Lancet,1994,343(8900):798-799.
[5] STRUPP M,LOPEZ-ESCAMEZ J A,KIM J S,et al.Vestibular paroxysmia:diagnostic criteria[J].Vestib Res,2016,26:409-415.
[6] 姜树军,单希征.巴拉尼协会前庭阵发症诊断标准解读[J].北京医学,2017,39(8):847-849.
[7] BRANDT T,DIETERICH M,Strupp M.Peripheral vestibular forms of vertigo.in:vertigo and dizziness[M].London:Springer,2013:53-110.
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[9] LEHNEN N,LANGHAGEN T,HEINEN F,et al.Vestibular paroxysmia in children:a treatable cause of short vertigo attacks[J].Developmental Medicine & Child Neurology,2015,57(4):393-396.
[10] HüFNER K,LINN J,STRUPP M.Recurrent attacks of vertigo with monocular oscillopsia[J].Neurology,2008,71(11):863.
[11] LANG J.Anatomy,length and blood vessel relations of “central” and “peripheral” paths of intracisternal cranial nerves [J].Zentralbl Neurochir 1982,43(3):217-258.
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[14] HALLER S,ETIENNE L,KOVARI E,et al.Imaging of neurovascular compression syndromes:trigeminal neuralgia,hemifacial spasm,vestibular paroxysmia,and glossopharyngeal neuralgia[J].American Journal of Neuroradiology,2016,37(8):1384-1392.
[15] MOLLER A R.The cranial nerve vascular compression syndrome:Ⅱ.a review of pathophysiology[J].Acta Neurochirurgica,1991,113(1/2):24-30.
[16] SCHWABER M K,WHETSELL W O .Cochleovestibular nerve compression syndrome.Ⅱ.Vestibular nerve histopathology and theory of pathophysiology[J].The Laryngoscope,1992,102(9):1030-1036.
[17] CHANG T P,WU Y C,HSU Y C.Vestibular paroxysmia associated with paroxysmal pulsatile tinnitus:a case report and review of the literature[J].Acta Neurologica Taiwanica,2013,22(2):72-75.
[18] WARD B K,GOLD D R.Tinnitus,Oscillopsia,and Hyperventilation-induced nystagmus:vestibular paroxysmia[J].Open Journal of Clinical & Medical Case Reports,2016,2(7):1100.
[19] ORI M,GAMBACORTA V,RICCI G,et al.Vestibular paroxysmia in vestibular neuritis:a case report[J].Audiology Research,2018,8(1):206.
[20] RYU H,YAMAMOTO S,SUGIYAMA K,et al.Neurovascular compression syndrome of the eighth cranial nerve.what are the most reliable diagnostic signs?[J].Acta Neurochirurgica,1998,140(12):1279-1286.
[21] APPLEBAUM E L,VALVASSORI G E.Auditory and vestibular system findings in patients with vascular loops in the internal auditory canal[J].Annals of Otology,Rhinology & Laryngology,1984,93(4_suppl):63-70.
[22] MOLLER M B.Results of Microvascular Decompression(MVD)of the eighth nerve as treatment for disabling positional vertigo[J].Ann Otol Rhinol Laryngol,1990,99(1):724-729.
[23] SCHWABER M K,HALL J W .Cochleovestibular nerve compression syndrome.I.Clinical features and audiovestibular findings[J].Laryngoscope,1992,102(9):1020-1029.
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[26] JU HAN LEE,SUNG-KWANG HONG.Is the auditory brainstem response diagnostic for vestibular paroxysmia?[J].Vestib Sci,2018,17(2):55-59.
[27] SINGH N K,SINGH P,USHA M,et al.Audio-vestibular findings in vestibular paroxysmia [J].Indian J Otol,2013,19(2):82-84.
[28] BRANDT T,STRUPP M,DIETERICH M.Vestibular paroxysmia:a treatable neurovascular cross-compression syndrome[J].Neurol,2016,263(Suppl 1) :90-96.
[29] ROMMER P S,GERALD W,CLAUDIA K,et al.7-Tesla MRI demonstrates absence of structural lesions in patients with vestibular paroxysmia[J].Frontiers in Neuroanatomy,2015,9:81.
[30] LOPEZ-ESCAMEZ J A,CAREY J,CHUNG W H,et al.Diagnostic criteria for Meniere′s disease[J].Journal of Vestibular Research,2015,25(1):1-7.
[31] LEMPERT T,OLESEN J,FURMAN J,et al.Vestibular migraine:Diagnostic criteria[J].Journal of Vestibular Research,2012,22(4):167-172.
[32] BAYER O,STRUPP M,HUFNER K.A randomized double-blind,placebo-controlled,cross-over trial (Vestparoxy) of the treatment of vestibular paroxysmia with oxcarbazepine[J].Journal of Neurology,2018,265(2):291-298.
[33] 陈素芬,赵岳中,胡珏,等.奥卡西平治疗前庭阵发症的疗效观察[J].中国医药指南,2017,15(11):29-30.
[34] STRUPP M,DIETERICH M,BRANDT T,et al.Therapy of vestibular paroxysmia,superior oblique myokymia,and ocular neuromyotonia[J].Current Treatment Options in Neurology,2016,18(7):34.
[35] 李建辉.卡马西平联合敏使朗治疗前庭阵发症的疗效观察[J].中国伤残医学,2013,21(10):41-42.
[36] YI C,WENPING X,HUI X,et al.Efficacy and acceptability of oxcarbazepine vs.carbamazepine with betahistine mesilate tablets in treating vestibular paroxysmia:a retrospective review[J].Postgraduate Medicine,2016,128(5):492-495.
[37] HUI X,WENPING X,YICHUAN Y,et al.Randomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia[J].Drug Design,Development and Therapy,2018,12:837-843.
[38] STRUPP M,VON STUCKRAD-BARRE S,BRANDT T,et al.teaching neuroImages:compression of the eighth cranial nerve causes vestibular paroxysmia[J].Neurology,2013,80(7):e77-e77.
[39] BRACKMANN D E,KESSER B W,DAY J D .Microvascular decompression of the vestibulocochlear nerve for disabling positional vertigo:the house ear clinic experience[J].Otology & Neurotology,2001,22(6):882-887.
[40] JANNETTA P J .Outcome after microvascular decompression for typical trigeminal neuralgia,hemifacial spasm,tinnitus,disabling positional vertigo,and glossopharyngeal neuralgia (honored guest lecture)[J].Clinical Neurosurgery,1997,44(44):331-383.
[41] ESPOSITO G,MESSINA R,CARAI A,et al.Cochleovestibular nerve compression syndrome due to intrameatal anterior Inferior cerebellar artery Ioop:synthesis of best evidence for clinical decisions[J].World Neurosurgery,2016,96:556-561.
[2] JANNETTA P J,MARGARETA B,AAGE R.Disabling positional vertigo[J].New England Journal of Medicine,1984,310(26):1700-1705.
[3] MOLLER M B,MOLLER A R,JANNETTA P J,et al.Diagnosis and surgical treatment of disabling positional vertigo[J].Journal of Neurosurgery,1986,64(1):21-28.
[4] BRANDT T,DIETERICH M .Vestibular paroxysmia:vascular compression of the eighth nerve?[J].Lancet,1994,343(8900):798-799.
[5] STRUPP M,LOPEZ-ESCAMEZ J A,KIM J S,et al.Vestibular paroxysmia:diagnostic criteria[J].Vestib Res,2016,26:409-415.
[6] 姜树军,单希征.巴拉尼协会前庭阵发症诊断标准解读[J].北京医学,2017,39(8):847-849.
[7] BRANDT T,DIETERICH M,Strupp M.Peripheral vestibular forms of vertigo.in:vertigo and dizziness[M].London:Springer,2013:53-110.
[8] HüFNER K,BARRESI D,GLASER M,et al.Vestibular paroxysmia:diagnostic features and medical treament [J].Neurology,2008,71(13):1006-1014.
[9] LEHNEN N,LANGHAGEN T,HEINEN F,et al.Vestibular paroxysmia in children:a treatable cause of short vertigo attacks[J].Developmental Medicine & Child Neurology,2015,57(4):393-396.
[10] HüFNER K,LINN J,STRUPP M.Recurrent attacks of vertigo with monocular oscillopsia[J].Neurology,2008,71(11):863.
[11] LANG J.Anatomy,length and blood vessel relations of “central” and “peripheral” paths of intracisternal cranial nerves [J].Zentralbl Neurochir 1982,43(3):217-258.
[12] DE RIDDER D,MOLLER A,VERLOOY J,et al.Is the root entry/exit zone important in microvascular compression syndromes?[J].Neurosurgery,2002,51(2):427-434.
[13] BEST C,GAWEHN J,KRAMER H H,et al.MRI and neurophysiology in vestibular paroxysmia:contradiction and correlation[J].Journal of Neurology,Neurosurgery & Psychiatry,2013,84(12):1349-1356.
[14] HALLER S,ETIENNE L,KOVARI E,et al.Imaging of neurovascular compression syndromes:trigeminal neuralgia,hemifacial spasm,vestibular paroxysmia,and glossopharyngeal neuralgia[J].American Journal of Neuroradiology,2016,37(8):1384-1392.
[15] MOLLER A R.The cranial nerve vascular compression syndrome:Ⅱ.a review of pathophysiology[J].Acta Neurochirurgica,1991,113(1/2):24-30.
[16] SCHWABER M K,WHETSELL W O .Cochleovestibular nerve compression syndrome.Ⅱ.Vestibular nerve histopathology and theory of pathophysiology[J].The Laryngoscope,1992,102(9):1030-1036.
[17] CHANG T P,WU Y C,HSU Y C.Vestibular paroxysmia associated with paroxysmal pulsatile tinnitus:a case report and review of the literature[J].Acta Neurologica Taiwanica,2013,22(2):72-75.
[18] WARD B K,GOLD D R.Tinnitus,Oscillopsia,and Hyperventilation-induced nystagmus:vestibular paroxysmia[J].Open Journal of Clinical & Medical Case Reports,2016,2(7):1100.
[19] ORI M,GAMBACORTA V,RICCI G,et al.Vestibular paroxysmia in vestibular neuritis:a case report[J].Audiology Research,2018,8(1):206.
[20] RYU H,YAMAMOTO S,SUGIYAMA K,et al.Neurovascular compression syndrome of the eighth cranial nerve.what are the most reliable diagnostic signs?[J].Acta Neurochirurgica,1998,140(12):1279-1286.
[21] APPLEBAUM E L,VALVASSORI G E.Auditory and vestibular system findings in patients with vascular loops in the internal auditory canal[J].Annals of Otology,Rhinology & Laryngology,1984,93(4_suppl):63-70.
[22] MOLLER M B.Results of Microvascular Decompression(MVD)of the eighth nerve as treatment for disabling positional vertigo[J].Ann Otol Rhinol Laryngol,1990,99(1):724-729.
[23] SCHWABER M K,HALL J W .Cochleovestibular nerve compression syndrome.I.Clinical features and audiovestibular findings[J].Laryngoscope,1992,102(9):1020-1029.
[24] HALL J W.Classic Site-of-Lesion Tests:foundation of diagnostic audiology.in:hearing assessment.W.Rintelmann (Ed.)[M].Pro-Ed,Austin,Texas,1990:653-677.
[25] DE RIDDER D,HEIJNEMAN K,HAARMAN B,et al.Tinnitus in vascular conflict of the eighth cranial nerve:a surgical pathophysiological approach to ABR changes[J].Progress in brain research,2007,166(1):401-411.
[26] JU HAN LEE,SUNG-KWANG HONG.Is the auditory brainstem response diagnostic for vestibular paroxysmia?[J].Vestib Sci,2018,17(2):55-59.
[27] SINGH N K,SINGH P,USHA M,et al.Audio-vestibular findings in vestibular paroxysmia [J].Indian J Otol,2013,19(2):82-84.
[28] BRANDT T,STRUPP M,DIETERICH M.Vestibular paroxysmia:a treatable neurovascular cross-compression syndrome[J].Neurol,2016,263(Suppl 1) :90-96.
[29] ROMMER P S,GERALD W,CLAUDIA K,et al.7-Tesla MRI demonstrates absence of structural lesions in patients with vestibular paroxysmia[J].Frontiers in Neuroanatomy,2015,9:81.
[30] LOPEZ-ESCAMEZ J A,CAREY J,CHUNG W H,et al.Diagnostic criteria for Meniere′s disease[J].Journal of Vestibular Research,2015,25(1):1-7.
[31] LEMPERT T,OLESEN J,FURMAN J,et al.Vestibular migraine:Diagnostic criteria[J].Journal of Vestibular Research,2012,22(4):167-172.
[32] BAYER O,STRUPP M,HUFNER K.A randomized double-blind,placebo-controlled,cross-over trial (Vestparoxy) of the treatment of vestibular paroxysmia with oxcarbazepine[J].Journal of Neurology,2018,265(2):291-298.
[33] 陈素芬,赵岳中,胡珏,等.奥卡西平治疗前庭阵发症的疗效观察[J].中国医药指南,2017,15(11):29-30.
[34] STRUPP M,DIETERICH M,BRANDT T,et al.Therapy of vestibular paroxysmia,superior oblique myokymia,and ocular neuromyotonia[J].Current Treatment Options in Neurology,2016,18(7):34.
[35] 李建辉.卡马西平联合敏使朗治疗前庭阵发症的疗效观察[J].中国伤残医学,2013,21(10):41-42.
[36] YI C,WENPING X,HUI X,et al.Efficacy and acceptability of oxcarbazepine vs.carbamazepine with betahistine mesilate tablets in treating vestibular paroxysmia:a retrospective review[J].Postgraduate Medicine,2016,128(5):492-495.
[37] HUI X,WENPING X,YICHUAN Y,et al.Randomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia[J].Drug Design,Development and Therapy,2018,12:837-843.
[38] STRUPP M,VON STUCKRAD-BARRE S,BRANDT T,et al.teaching neuroImages:compression of the eighth cranial nerve causes vestibular paroxysmia[J].Neurology,2013,80(7):e77-e77.
[39] BRACKMANN D E,KESSER B W,DAY J D .Microvascular decompression of the vestibulocochlear nerve for disabling positional vertigo:the house ear clinic experience[J].Otology & Neurotology,2001,22(6):882-887.
[40] JANNETTA P J .Outcome after microvascular decompression for typical trigeminal neuralgia,hemifacial spasm,tinnitus,disabling positional vertigo,and glossopharyngeal neuralgia (honored guest lecture)[J].Clinical Neurosurgery,1997,44(44):331-383.
[41] ESPOSITO G,MESSINA R,CARAI A,et al.Cochleovestibular nerve compression syndrome due to intrameatal anterior Inferior cerebellar artery Ioop:synthesis of best evidence for clinical decisions[J].World Neurosurgery,2016,96:556-561.