胶质瘤相关性癫痫组织高迁移率族蛋白B1的表达
摘要
目的探讨胶质瘤相关性癫痫致痫组织中蛋白B1的表达。方法选取72例胶质瘤相关性癫痫患者的胶质瘤标本作胶质瘤并癫痫组,同期行手术治疗的70例未伴发癫痫的胶质瘤患者的胶质瘤标本作胶质瘤无癫痫组,同期70例药物难治性癫痫患者致痫病灶标本作非肿瘤癫痫组,20例接受颅内减压术治疗的患者的脑组织标本作对照组。分析胶质瘤并癫痫组患者癫痫发生情况及胶质瘤病理级别和高迁移率族蛋白B1表达水平的关系、四组高迁移率族蛋白B1表达情况、胶质瘤并癫痫组胶质瘤病理级别对癫痫的影响。结果胶质瘤并癫痫组患者胶质瘤组织中高迁移率族蛋白B1表达与胶质瘤病理级别(r=0.154,P<0.05)、癫痫发作频率(r=0.429,P<0.05)及癫痫持续时间(r=0.254,P<0.05)呈正相关;胶质瘤并癫痫组高迁移率族蛋白B1表达阳性率显著高于胶质瘤无癫痫组(χ~2=8.990,P<0.05)、非肿瘤癫痫组(χ~2=19.864,P<0.05),胶质瘤无癫痫组显著高于对照组(χ~2=32.699,P<0.05),非肿瘤癫痫组显著高于对照组(χ~2=20.793,P<0.05);高迁移率族蛋白B1在中低级别中表达水平显著高于高级别(χ~2=11.614,P<0.05),高迁移率族蛋白B1在高级别胶质瘤中的表达水平与是否并发癫痫有关(χ~2=11.445,P<0.05)。结论高迁移率族蛋白B1在胶质瘤相关性癫痫致痫组织中具有较高表达水平,胶质瘤组织中高迁移率族蛋白B1可能是诱发相关性癫痫的重要因素。
引文
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9 Huang YJ,He Y,Chen M,et al.Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma associated epilepsy〔J〕.Mol Med Rep,2015;12(5):6509-16.
10 周少龙,王新军,付旭东,等.伴有癫痫的人脑胶质瘤中HMGB1/TLR4的表达研究〔J〕.中华神经医学杂志,2015;14(6):563-6.
11 王新军,杨如意,单峤,等.胶质瘤相关性癫痫瘤组织中高迁移率族蛋白B1表达与痫性发作〔J〕.中国神经精神疾病杂志,2015;41(3):155-9.
12 Zhong Z,Wang Z,Wang Y,et al.IDH1/2 mutation is associated with seizure as an initial symptom in low-grade glioma:A report of 311 Chinese adult glioma patients〔J〕.Epilepsy Res,2015;109(9):100-5.
13 朱晋,张玉琪,万虹,等.组蛋白去乙酰化酶3与小儿胶质瘤发病和预后的关系〔J〕.中华神经外科杂志,2014;30(11):1145-8.
2 韩笑,吴琼石,杨薇,等.脑胶质瘤中丝氨酸蛋白酶抑制剂、血管内皮生长因子表达及对血管生成的影响〔J〕.中国老年学杂志,2015;35(20):5831-3.
3 Murata Y,Taniguchi G,Watanabe O,et al.A case of autoimmune epilepsy associated with anti-leucine-rich glioma inactivated subunit 1 antibodies manifesting electrical shock-like sensations and transparent sadness〔J〕.Epilepsy Behav Case Rep,2015;4(8):91-3.
4 王引言,毛庆,王江飞,等.低级别胶质瘤占位效应与术后癫痫缓解率的相关性研究〔J〕.中华神经外科杂志,2014;30(10):1031-4.
5 Pyken TC,Parney I,Buatti J,et al.The role of radiotherapy in the management of patients with diffuse low grade glioma:a systematic review and evidence-based clinical practice guideline〔J〕.J Neurooncol,2015;125(3):551-83.
6 郭成永,梁朝辉,魏可欣,等.解旋酶RECQ1和细胞核相关抗原Ki-67 在脑胶质瘤组织中的表达及相关性〔J〕.中国老年学杂志,2015;35(12):3259-60.
7 Loredana M,Dinapoli L,Fabi A,et al.Cognitive rehabilitation training in patients with brain tumor-related epilepsy and cognitive deficits:a pilot study〔J〕.J Neurooncol,2015;125(2):419-26.
8 杨如意,李培栋,吴建珩,等.人脑胶质瘤组织HMGB1表达与胶质瘤相关性癫痫关系的探讨〔J〕.中华肿瘤防治杂志,2015;22(15):1180-3.
9 Huang YJ,He Y,Chen M,et al.Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma associated epilepsy〔J〕.Mol Med Rep,2015;12(5):6509-16.
10 周少龙,王新军,付旭东,等.伴有癫痫的人脑胶质瘤中HMGB1/TLR4的表达研究〔J〕.中华神经医学杂志,2015;14(6):563-6.
11 王新军,杨如意,单峤,等.胶质瘤相关性癫痫瘤组织中高迁移率族蛋白B1表达与痫性发作〔J〕.中国神经精神疾病杂志,2015;41(3):155-9.
12 Zhong Z,Wang Z,Wang Y,et al.IDH1/2 mutation is associated with seizure as an initial symptom in low-grade glioma:A report of 311 Chinese adult glioma patients〔J〕.Epilepsy Res,2015;109(9):100-5.
13 朱晋,张玉琪,万虹,等.组蛋白去乙酰化酶3与小儿胶质瘤发病和预后的关系〔J〕.中华神经外科杂志,2014;30(11):1145-8.