替加环素联合头孢哌酮舒巴坦钠治疗广泛耐药鲍曼不动杆菌老年肺部感染疗效探析
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摘要
目的探讨替加环素联合头孢哌酮舒巴坦钠治疗广泛耐药鲍曼不动杆菌老年肺部感染效果。方法方便选取该院2017年4月—2018年4月收治的广泛耐药鲍曼不动杆菌老年肺部感染患者90例,随机分为两组,对照组采取头孢哌酮舒巴坦钠进行治疗,研究组采取替加环素联合头孢哌酮舒巴坦钠的方法进行治疗。结果对照组治疗有效率为46.5%,研究组治疗有效率为79.9%,研究组治疗效果明显优于对照组,差异有统计学意义(χ2=5.347,P<0.05),对照组清除率为13.3%,研究组有效率为42.2%,研究组广泛耐药鲍曼不动杆菌清除率高于对照组,差异有统计学意义(χ2=5.546,P<0.05)。结论在治疗多重耐药鲍曼不动杆菌肺炎的过程中,头孢哌酮舒巴坦钠联合替加环素进行治疗疗效好,效果较为理想,临床上应当进一步推广应用。
Objective To investigate the effect of tigecycline combined with cefoperazone sulbactam in the treatment of elderly patients with lung infection with Acinetobacter baumannii. Methods A total of 90 elderly patients with lung-infected Acinetobacter baumannii who were admitted to the hospital from April 2017 to April 2018 were convenient selected and randomly divided into two groups. The control group was treated with cefoperazone and sulbactam sodium. The study group was treated with tigecycline combined with cefoperazone sulbactam sodium. Results The effective rate of the control group was 46.5%, and the effective rate of the study group was 79.9%. The treatment effect of the study group was significantly better than that of the control group,the different was statistically significant(χ2=5.347, P<0.05), and the clearance rate of the control group was 13.3% and 42.2% of the study group, the clearance rate of extensive drug-resistant Acinetobacter baumannii in the study group was higher than that in the control group(χ2=5.546, P<0.05). Conclusion In the treatment of multi-drug resistant Acinetobacter baumannii pneumonia, cefoperazone sulbactam sodium combined with tigecycline is effective, and should be further promoted and applied clinically.
Objective To investigate the effect of tigecycline combined with cefoperazone sulbactam in the treatment of elderly patients with lung infection with Acinetobacter baumannii. Methods A total of 90 elderly patients with lung-infected Acinetobacter baumannii who were admitted to the hospital from April 2017 to April 2018 were convenient selected and randomly divided into two groups. The control group was treated with cefoperazone and sulbactam sodium. The study group was treated with tigecycline combined with cefoperazone sulbactam sodium. Results The effective rate of the control group was 46.5%, and the effective rate of the study group was 79.9%. The treatment effect of the study group was significantly better than that of the control group,the different was statistically significant(χ2=5.347, P<0.05), and the clearance rate of the control group was 13.3% and 42.2% of the study group, the clearance rate of extensive drug-resistant Acinetobacter baumannii in the study group was higher than that in the control group(χ2=5.546, P<0.05). Conclusion In the treatment of multi-drug resistant Acinetobacter baumannii pneumonia, cefoperazone sulbactam sodium combined with tigecycline is effective, and should be further promoted and applied clinically.
引文
[1]龙鼎,喻莉,杨军辉.替加环素联合头孢哌酮舒巴坦钠治疗广泛耐药鲍曼不动杆菌老年肺部感染疗效观察[J].中华实用诊断与治疗杂志,2016,30(5):512-514.
[2]李儒,王旭明,郭红荔,等.替加环素联合头孢哌酮舒巴坦对多重耐药鲍曼不动杆菌肺部感染患者的临床疗效及机制探讨[J].中国医院药学杂志,2017,37(5):450-453.
[3]李金秀,夏天,潘童.头孢哌酮舒巴坦钠与替加环素联合治疗ICU泛耐药鲍曼不动杆菌呼吸道感染的临床疗效及安全性[J].中国临床研究,2017,30(7):886-889.
[4]王佳,骆霞,王林海,等.替加环素联合头孢哌酮舒巴坦钠治疗多重/泛耐药鲍曼不动杆菌致肺炎的Meta分析[J].临床药物治疗杂志,2017,15(1):38-42.
[5]李双,张广庆,刘玉才.替加环素不同治疗方案对ICU泛耐药鲍曼不动杆菌肺部感染的临床效果对比观察[J].中国抗生素杂志,2018,45(2):139-145.
[6]王娟,李德宪,俞朝贤,等.替加环素联合治疗泛耐药鲍曼不动杆菌肺部感染的临床疗效[J].热带医学杂志,2016,16(5):625-628.
[7]陈文武,钟雪辉.替加环素联合异帕米星治疗多重耐药鲍曼不动杆菌肺炎的临床观察[J].中国药房,2016,27(29):4133-4135.
[8]徐凡翔,张娟红,徐丽婷.替加环素联合头孢哌酮舒巴坦治疗多重耐药鲍曼不动杆菌肺炎的临床疗效观察[J].解放军药学学报,2017,32(3):285-286.
[9]安庆丽,喻昌利,王键玮,等.头孢哌酮舒巴坦联合米诺环素治疗多重耐药鲍曼不动杆菌肺炎疗效评价[J].实用药物与临床,2016,19(5):558-561.
[2]李儒,王旭明,郭红荔,等.替加环素联合头孢哌酮舒巴坦对多重耐药鲍曼不动杆菌肺部感染患者的临床疗效及机制探讨[J].中国医院药学杂志,2017,37(5):450-453.
[3]李金秀,夏天,潘童.头孢哌酮舒巴坦钠与替加环素联合治疗ICU泛耐药鲍曼不动杆菌呼吸道感染的临床疗效及安全性[J].中国临床研究,2017,30(7):886-889.
[4]王佳,骆霞,王林海,等.替加环素联合头孢哌酮舒巴坦钠治疗多重/泛耐药鲍曼不动杆菌致肺炎的Meta分析[J].临床药物治疗杂志,2017,15(1):38-42.
[5]李双,张广庆,刘玉才.替加环素不同治疗方案对ICU泛耐药鲍曼不动杆菌肺部感染的临床效果对比观察[J].中国抗生素杂志,2018,45(2):139-145.
[6]王娟,李德宪,俞朝贤,等.替加环素联合治疗泛耐药鲍曼不动杆菌肺部感染的临床疗效[J].热带医学杂志,2016,16(5):625-628.
[7]陈文武,钟雪辉.替加环素联合异帕米星治疗多重耐药鲍曼不动杆菌肺炎的临床观察[J].中国药房,2016,27(29):4133-4135.
[8]徐凡翔,张娟红,徐丽婷.替加环素联合头孢哌酮舒巴坦治疗多重耐药鲍曼不动杆菌肺炎的临床疗效观察[J].解放军药学学报,2017,32(3):285-286.
[9]安庆丽,喻昌利,王键玮,等.头孢哌酮舒巴坦联合米诺环素治疗多重耐药鲍曼不动杆菌肺炎疗效评价[J].实用药物与临床,2016,19(5):558-561.