通痹舒心颗粒治疗急性冠脉综合征合并抑郁症临床研究
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摘要
目的观察通痹舒心颗粒治疗急性冠脉综合征合并抑郁症的疗效。方法将97例随机分为治疗组49例,对照组48例。对照组遵"ACS指南"进行心血管药物治疗并予以情志干预,治疗组在对照组治疗的基础上加服通痹舒心颗粒。疗程4周,观察心绞痛的发作次数、持续时间和患者的抑郁量表(HAMD)及焦虑量表(HAMA)评分等指标。结果治疗前后两组对改善心绞痛症状均有较好疗效,治疗组总有效率为91.84%,优于对照组的68.75%(P<0.05)。两组治疗后心绞痛发作次数、持续时间均较治疗前明显改善,且治疗组疗效优于对照组(P<0.01)。两组患者HAMD及HAMA评分均较治疗前有明显下降,且治疗组评分下降低于对照组(P<0.05或P<0.01)。在治疗4周后治疗组有效率为95.92%,高于对照组的52.08%(P<0.01)。结论通痹舒心颗粒治疗急性冠脉综合征抑郁症的疗效确切。
Objective: To study the effects of Tongbishuxin Particle on acute coronary syndrome with depression.Methods: Eligible patients were randomly divided into control group of 48 cases.with the guidelines for cardiovascular medications and be emotional intervention,the treatment group of 49 patients in the control group therapy plus service Tongbishuxin Particle. In the 4 weeks of treatment,these indieces were observed frequency and duration of angina episodes and patients Depression Scale(HAMD) and Anxiety Scale(HAMA) score and other indicators. Results: After treatment,these effects in two groups were improved significantly in the symptoms of angina.. The effective rate with 91.84% in the treatment group was superior to that with 68.75% in the control group(P < 0.01). After treatment,frequency and duration of angina episodes significantly improved compared them before treatment. There was a significant difference between two groups(P < 0.01). HAMD and HAMA scores of patients in two groups decreased significantly compared with before treatment,but the treatment group was significantly decreased,compared with statistical significance(P < 0.05). There was a significant difference between the two groups after treatment(P < 0.01). After 4 weeks of treatment,the effective rate of 95.92% in the treatment group,and 52.08% in the control group,there were significant differences in efficiency between the two groups(P < 0.01). Conclusion: Tongbishuxin Particle has the exact treatment effect combined with acute coronary syndrome with depression.
Objective: To study the effects of Tongbishuxin Particle on acute coronary syndrome with depression.Methods: Eligible patients were randomly divided into control group of 48 cases.with the guidelines for cardiovascular medications and be emotional intervention,the treatment group of 49 patients in the control group therapy plus service Tongbishuxin Particle. In the 4 weeks of treatment,these indieces were observed frequency and duration of angina episodes and patients Depression Scale(HAMD) and Anxiety Scale(HAMA) score and other indicators. Results: After treatment,these effects in two groups were improved significantly in the symptoms of angina.. The effective rate with 91.84% in the treatment group was superior to that with 68.75% in the control group(P < 0.01). After treatment,frequency and duration of angina episodes significantly improved compared them before treatment. There was a significant difference between two groups(P < 0.01). HAMD and HAMA scores of patients in two groups decreased significantly compared with before treatment,but the treatment group was significantly decreased,compared with statistical significance(P < 0.05). There was a significant difference between the two groups after treatment(P < 0.01). After 4 weeks of treatment,the effective rate of 95.92% in the treatment group,and 52.08% in the control group,there were significant differences in efficiency between the two groups(P < 0.01). Conclusion: Tongbishuxin Particle has the exact treatment effect combined with acute coronary syndrome with depression.
引文
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[2]王吉耀.内科学[M].北京:人民卫生出版社,2002:245.
[3]季建林.医学心理学[M].上海:复旦大学出版社,2005:234.
[4]Strik JJ,Denollet J,Lousberg R,et al.Comparing symptoms of depression and predictors of cardiac events and increased health consumption after myocardial infarction[J].J Am Coll Cardiol,2003,42:1808-1810.
[5]Martin CR,Thompson DR,Chan DS.An examination of the psychometric properties of the Hospital Anxiety and Depression Scale in Chinese patients with acute coronary syndrome[J].Psychiatry Res,2004,129:279-288.
[6]Grace SL,Abbey SE,Kapral MK,et al.Effect of depression on five-year mortality after an acuter coronary syndome[J].Am J Cardiol,2005,96:1179-1185.
[7]胡大一,郭艺芳.急性冠脉综合征的诊治进展[J].中国实用内科杂志,2008,28(1):1-2.