葡萄酒色斑的光动力治疗进展
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摘要
葡萄酒色斑(port wine stain,PWS)是一种在新生儿中常见的先天性的真皮层毛细血管畸形。目前PWS的临床一线的治疗方式为脉冲染料激光,但完全清除率低。20世纪90年代,我国首先将光动力治疗(photodynamic therapy,PDT)用于PWS的治疗。后续大量研究验证了PDT用于PWS治疗的疗效和安全性。本文就PDT在治疗葡萄酒色斑上的应用及研究进展进行综述。
Port-wine stain( PWS) one of the most common types of congenital and progressive vascular malformation,is characterized by ectatic capillaries and post capillary venules in the dermis. Being commonly used method for PWS at present,pulsed dye laser( PDL) is still unsatisfactory in terms of total clearance. Photodynamic therapy( PDT) was firstly used to treat PWS in the 1990 s in China. Extensive clinical researches have demonstrated that it has high therapeutic efficiency and few side effects. In this article,PDT application for treating port-wine stain and the progress made in related researches were reviewed.
Port-wine stain( PWS) one of the most common types of congenital and progressive vascular malformation,is characterized by ectatic capillaries and post capillary venules in the dermis. Being commonly used method for PWS at present,pulsed dye laser( PDL) is still unsatisfactory in terms of total clearance. Photodynamic therapy( PDT) was firstly used to treat PWS in the 1990 s in China. Extensive clinical researches have demonstrated that it has high therapeutic efficiency and few side effects. In this article,PDT application for treating port-wine stain and the progress made in related researches were reviewed.
引文
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[2]Chen JK,Ghasri P,Aguilar G,et al.An overview of clinical and experimental treatment modalities for port-wine stains[J].J Am Acad Dermatol,2012,67:289-304.
[3]Smoller BR,Rosen S.Port wine stains.A disease of altered neural modulation of blood vessels[J].Arch Dermatol,1986,122:177-179.
[4]Geronemus RG,Ashinoff R.The medical necessity of evaluation and treatment of port-wine stains[J].J Dermatol Surg Oncol,1991,17:76-79.
[5]Minkis K,Geronemus RG,Hale EK.Port wine stain progression:a potential consequence of delayed and inadequate treatment[J].Lasers Surg Med,2009,41:423-426.
[6]Malm M,Carlberg M.Port wine stain a surgical and psychological problem[J].Ann Plast Surg,1988,20:512-516.
[7]Ortiz AE,Nelson JS.Port-wine stain laser treatments and novel approaches[J].Facial Plast Surg,2012,28:611-620.
[8]王天佑,林晓曦.葡萄酒色斑光动力治疗致皮肤坏死的机制及其血管构筑基础[D].上海交通大学博士论文,2015.4.
[9]Gu Y,Li JH,Jiang YP,et al.A clinical study of photodynamic therapy for port wine stain:A report of 40 cases[J].Chin J Laser Med Surg,1992,1:6-10.
[10]Henderson BW,Dougherty TJ.How does photodynamic therapy work[J].Photochem Photobio,1992,55:145-157.
[11]Agarwal ML,Larkin HE,Zaidi SIA,et al.Phospholipase activation triggers apoptosis in photosensitized mouse lymphoma cells[J].Cancer Res,1993,53:5897-5902.
[12]Castano AP,Mroz P,Hamblin MR.Photodynamic therapy and anti-tumour immunity[J].Nat Rev Cancer,2006,6:535-545.
[13]Lee Y,Baron ED.Photodynamic therapy:current evidence and applications in dermatology[J].Semin Cutan Med Surg,2011,30:199-209.
[14]顾瑛,李峻亨,许德余,等.新型光敏剂-血卟啉单甲醚临床应用研究的初步报道[J].中国激光医学杂志,1993,2:235-236.
[15]李若虹,周展超,林彤,等.血卟啉单甲醚在血管内皮细胞和角质形成细胞的亚细胞定位及光动力治疗作用点[J].中国激光医学杂志,2011,20:154-159.
[16]Zhao Y,Tu P,Zhou GY,et al.Hemoporfin photodynamic therapy for port wine stain:a randomized controlled trial[J].PLo S ONE,2016,11:e0156219.
[17]Tang Y,Xie HF,Li J,et al.The association between treatment reactions and treatment efficiency of Hemoporfin-photodynamic therapy on port wine stains:A prospective double blind randomized controlled trial[J].Photodiagnosis Photodyn Ther,2017,18:171-178.
[18]Lopez RFV,Lange N,Guy R,et al.Photodynamic therapy of skin cancer:controlled drug delivery of 5-ALA and its esters[J].Adv Drug Deliv Rev,2004,56:77-94.
[19]Li W,Yamada I,Masumoto K,et al.Photodynamic therapy with intradermal administration of 5-aminolevulinic acid for port-wine stains[J].J Dermatolog Treat,2010,21:232-239.
[20]Nelson JS,Roberts WG,Berns MW.In vivo studies on the utilization of mono-L-aspartyl chlorin(NPe6)for photodynamic therapy[J].Cancer Res,1987,47:4681-4685.
[21]Kujundzic M,Vogl TJ,Stimac D,et al.A PhaseⅡsafety and effect on time to tumor progression study of intratumoral light infusion technology using talaporfin sodium in patients with metastatic colorectal cancer[J].J Surg Oncol,2007,96:518-524.
[22]Moy WJ,Yao J,de Feraudy Sébastien M,et al.Histologic changes associated with talaporfin sodium-mediated photodynamic therapy in rat skin[J].Lasers Surg Med,2017,49:767-772.
[23]Kelly KM,Moy WJ,Moy AJ,et al.Talaporfin sodium-mediated photodynamic therapy alone and in combination with pulsed dye laser on cutaneous vasculature[J].J Invest Dermatol,2015,135:302-304.
[24]Tournas JA,Lai J,Truitt A,et al.Combined benzoporphyrin derivative monoacid ring photodynamic therapy and pulsed dye laser for port wine stain birthmarks[J].Photodiagnosis Photodyn Ther,2009,6:195-199.
[25]Kelly KM,Kimel S,Smith T,et al.Combined photodynamic and photothermal induced injury enhances damage to in vivo model blood vessels[J].Lasers Surg Med,2004,34:407-413.
[26]张倩.金丝桃素光动力对鲜红斑痣的治疗作用及机制研究[D].第三军医大学,2015.
[27]Rikihisa N,Watanabe S,Satoh K,et al.Photosensitizer effects of artificial red cells on dye laser irradiation in an animal model assuming port wine stain treatment[J].Plast Reconstr Surg,2017,139:707e-716e.
[28]Singh R,Lillard Jr JW.Nanoparticle-based targeted drug delivery[J].Exp Mol Pathol,2009,86:215-223.
[29]Rakovich A,Savateeva D,Rakovich T,et al.Cd Te quantum dot/dyehybrid system as photosensitizer for photodynamic therapy[J].Nanoscale Res Lett,2010,5:753-760.
[30]Zhang P,Steelant W,Kumar M,et al.Versatile photosensitizersfor photodynamic therapy at infrared excitation[J].J Am Chem Soc,2007,129:4526-4527.
[31]Chen W,Zhang J.Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment[J].J Nanosci Nanotechnol,2006,6:1159-1166.
[32]顾瑛,刘凡光,李峻亨,等.光动力疗法治疗鲜红斑痣1216例临床分析.中国激光医学杂志,2001,10:86-89.
[33]李伟,林晓曦.铜蒸汽激光光动力疗法治疗葡萄酒色斑的临床评价[J].实用美容整形外科杂志,2003,14:189-192.
[34]周国瑜,张志愿.氪激光光动力治疗鲜红斑痣的初步临床观察[J].上海口腔医学,2000,9:168-170.
[35]欧阳天祥,邢新,李军辉,等.红光光动力疗法治疗葡萄酒色斑的实验研究与临床应用[J].实用美容整形外科杂志,2002,13:25-28.
[36]Zhao Y,Zhou Z,Zhou G,et al.Efficacy and safety of hemoporfin in photodynamic therapy for port-wine stain:a multicenter and open-labeled phase IIa study[J].Photodermatol Photoimmunol Photomed,2011,27:17-23.
[37]王玉芝,苑凯华.LED光源光动力疗法治疗鲜红斑痣.中国美容整形外科杂志,2017,27:404-406.
[38]Yuan KH,Li Q,Yu WL,et al.Comparison of photodynamic therapy and pulsed dye laser in patients with port wine stain birthmarks:a retrospective analysis.[J].Photodiagnosis Photodyn Ther,2008,5:50-57.
[39]Gao K,Huang Z,Yuan KH,et al.Side-by-side comparison of photodynamic therapy and pulsed-dye laser treatment of port-wine stain birthmarks[J].Br J Dermatol,2013,168:1040-1046.
[40]Zhang B,Zhang TH,Huang Z,et al.Comparison of pulsed dye laser(PDL)and photodynamic therapy(PDT)for treatment of facial port-wine stain(PWS)birthmarks in pediatric patients[J].Photodiagnosis Photodyn Ther,2014,11:491-497.
[41]鲁元刚,伍津津,杨宏珍,等.两种光敏剂对鲜红斑痣光动力学疗法的疗效影响[J].中国激光医学杂志,2008,1:28-31.
[42]Yuan KH,Gao JH,Huang Z.Adverse effects associated with photodynamic therapy(PDT)of port-wine stain(PWS)birthmarks[J].Photodiagnosis Photodyn Ther,2012,9:332-336.
[43]Houle Jean-Marie,Strong H Andrew.Duration of skin photosensitivity and incidence of photosensitivity reactions after administration of verteporfin.[J].Retina(Philadelphia,Pa.),2002,22:691-697.
[2]Chen JK,Ghasri P,Aguilar G,et al.An overview of clinical and experimental treatment modalities for port-wine stains[J].J Am Acad Dermatol,2012,67:289-304.
[3]Smoller BR,Rosen S.Port wine stains.A disease of altered neural modulation of blood vessels[J].Arch Dermatol,1986,122:177-179.
[4]Geronemus RG,Ashinoff R.The medical necessity of evaluation and treatment of port-wine stains[J].J Dermatol Surg Oncol,1991,17:76-79.
[5]Minkis K,Geronemus RG,Hale EK.Port wine stain progression:a potential consequence of delayed and inadequate treatment[J].Lasers Surg Med,2009,41:423-426.
[6]Malm M,Carlberg M.Port wine stain a surgical and psychological problem[J].Ann Plast Surg,1988,20:512-516.
[7]Ortiz AE,Nelson JS.Port-wine stain laser treatments and novel approaches[J].Facial Plast Surg,2012,28:611-620.
[8]王天佑,林晓曦.葡萄酒色斑光动力治疗致皮肤坏死的机制及其血管构筑基础[D].上海交通大学博士论文,2015.4.
[9]Gu Y,Li JH,Jiang YP,et al.A clinical study of photodynamic therapy for port wine stain:A report of 40 cases[J].Chin J Laser Med Surg,1992,1:6-10.
[10]Henderson BW,Dougherty TJ.How does photodynamic therapy work[J].Photochem Photobio,1992,55:145-157.
[11]Agarwal ML,Larkin HE,Zaidi SIA,et al.Phospholipase activation triggers apoptosis in photosensitized mouse lymphoma cells[J].Cancer Res,1993,53:5897-5902.
[12]Castano AP,Mroz P,Hamblin MR.Photodynamic therapy and anti-tumour immunity[J].Nat Rev Cancer,2006,6:535-545.
[13]Lee Y,Baron ED.Photodynamic therapy:current evidence and applications in dermatology[J].Semin Cutan Med Surg,2011,30:199-209.
[14]顾瑛,李峻亨,许德余,等.新型光敏剂-血卟啉单甲醚临床应用研究的初步报道[J].中国激光医学杂志,1993,2:235-236.
[15]李若虹,周展超,林彤,等.血卟啉单甲醚在血管内皮细胞和角质形成细胞的亚细胞定位及光动力治疗作用点[J].中国激光医学杂志,2011,20:154-159.
[16]Zhao Y,Tu P,Zhou GY,et al.Hemoporfin photodynamic therapy for port wine stain:a randomized controlled trial[J].PLo S ONE,2016,11:e0156219.
[17]Tang Y,Xie HF,Li J,et al.The association between treatment reactions and treatment efficiency of Hemoporfin-photodynamic therapy on port wine stains:A prospective double blind randomized controlled trial[J].Photodiagnosis Photodyn Ther,2017,18:171-178.
[18]Lopez RFV,Lange N,Guy R,et al.Photodynamic therapy of skin cancer:controlled drug delivery of 5-ALA and its esters[J].Adv Drug Deliv Rev,2004,56:77-94.
[19]Li W,Yamada I,Masumoto K,et al.Photodynamic therapy with intradermal administration of 5-aminolevulinic acid for port-wine stains[J].J Dermatolog Treat,2010,21:232-239.
[20]Nelson JS,Roberts WG,Berns MW.In vivo studies on the utilization of mono-L-aspartyl chlorin(NPe6)for photodynamic therapy[J].Cancer Res,1987,47:4681-4685.
[21]Kujundzic M,Vogl TJ,Stimac D,et al.A PhaseⅡsafety and effect on time to tumor progression study of intratumoral light infusion technology using talaporfin sodium in patients with metastatic colorectal cancer[J].J Surg Oncol,2007,96:518-524.
[22]Moy WJ,Yao J,de Feraudy Sébastien M,et al.Histologic changes associated with talaporfin sodium-mediated photodynamic therapy in rat skin[J].Lasers Surg Med,2017,49:767-772.
[23]Kelly KM,Moy WJ,Moy AJ,et al.Talaporfin sodium-mediated photodynamic therapy alone and in combination with pulsed dye laser on cutaneous vasculature[J].J Invest Dermatol,2015,135:302-304.
[24]Tournas JA,Lai J,Truitt A,et al.Combined benzoporphyrin derivative monoacid ring photodynamic therapy and pulsed dye laser for port wine stain birthmarks[J].Photodiagnosis Photodyn Ther,2009,6:195-199.
[25]Kelly KM,Kimel S,Smith T,et al.Combined photodynamic and photothermal induced injury enhances damage to in vivo model blood vessels[J].Lasers Surg Med,2004,34:407-413.
[26]张倩.金丝桃素光动力对鲜红斑痣的治疗作用及机制研究[D].第三军医大学,2015.
[27]Rikihisa N,Watanabe S,Satoh K,et al.Photosensitizer effects of artificial red cells on dye laser irradiation in an animal model assuming port wine stain treatment[J].Plast Reconstr Surg,2017,139:707e-716e.
[28]Singh R,Lillard Jr JW.Nanoparticle-based targeted drug delivery[J].Exp Mol Pathol,2009,86:215-223.
[29]Rakovich A,Savateeva D,Rakovich T,et al.Cd Te quantum dot/dyehybrid system as photosensitizer for photodynamic therapy[J].Nanoscale Res Lett,2010,5:753-760.
[30]Zhang P,Steelant W,Kumar M,et al.Versatile photosensitizersfor photodynamic therapy at infrared excitation[J].J Am Chem Soc,2007,129:4526-4527.
[31]Chen W,Zhang J.Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment[J].J Nanosci Nanotechnol,2006,6:1159-1166.
[32]顾瑛,刘凡光,李峻亨,等.光动力疗法治疗鲜红斑痣1216例临床分析.中国激光医学杂志,2001,10:86-89.
[33]李伟,林晓曦.铜蒸汽激光光动力疗法治疗葡萄酒色斑的临床评价[J].实用美容整形外科杂志,2003,14:189-192.
[34]周国瑜,张志愿.氪激光光动力治疗鲜红斑痣的初步临床观察[J].上海口腔医学,2000,9:168-170.
[35]欧阳天祥,邢新,李军辉,等.红光光动力疗法治疗葡萄酒色斑的实验研究与临床应用[J].实用美容整形外科杂志,2002,13:25-28.
[36]Zhao Y,Zhou Z,Zhou G,et al.Efficacy and safety of hemoporfin in photodynamic therapy for port-wine stain:a multicenter and open-labeled phase IIa study[J].Photodermatol Photoimmunol Photomed,2011,27:17-23.
[37]王玉芝,苑凯华.LED光源光动力疗法治疗鲜红斑痣.中国美容整形外科杂志,2017,27:404-406.
[38]Yuan KH,Li Q,Yu WL,et al.Comparison of photodynamic therapy and pulsed dye laser in patients with port wine stain birthmarks:a retrospective analysis.[J].Photodiagnosis Photodyn Ther,2008,5:50-57.
[39]Gao K,Huang Z,Yuan KH,et al.Side-by-side comparison of photodynamic therapy and pulsed-dye laser treatment of port-wine stain birthmarks[J].Br J Dermatol,2013,168:1040-1046.
[40]Zhang B,Zhang TH,Huang Z,et al.Comparison of pulsed dye laser(PDL)and photodynamic therapy(PDT)for treatment of facial port-wine stain(PWS)birthmarks in pediatric patients[J].Photodiagnosis Photodyn Ther,2014,11:491-497.
[41]鲁元刚,伍津津,杨宏珍,等.两种光敏剂对鲜红斑痣光动力学疗法的疗效影响[J].中国激光医学杂志,2008,1:28-31.
[42]Yuan KH,Gao JH,Huang Z.Adverse effects associated with photodynamic therapy(PDT)of port-wine stain(PWS)birthmarks[J].Photodiagnosis Photodyn Ther,2012,9:332-336.
[43]Houle Jean-Marie,Strong H Andrew.Duration of skin photosensitivity and incidence of photosensitivity reactions after administration of verteporfin.[J].Retina(Philadelphia,Pa.),2002,22:691-697.