穴位音乐电刺激治疗焦虑症的临床多中心随机对照研究（英文）
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摘要
目的:观察穴位音乐电刺激治疗焦虑症的疗效。方法:采用多中心随机对照试验(RCT)的方法,将270例焦虑症患者随机分为治疗组和药物组,治疗组采用穴位音乐电刺激治疗,药物组釆用口服多虑平治疗,两组治疗前后用汉密尔顿焦虑量表(HAMA)和焦虑自评量表中文修订版(SAS-CR)测评,并进行疗效比较。结果:治疗组总有效率为93.6%,药物组为92.3%,两组总有效率差异无统计学意义(P>0.05)。治疗后,两组HAMA和SAS-CR总分均与本组治疗前有统计学差异(均P<0.001),而两组间差异无统计学意义(均P>0.05)。结论:穴位音乐电刺激治疗焦虑症疗效与多虑平相当,可作为治疗焦虑症的方法。
Objective: To observe the therapeutic efficacy of music electric stimulation of points in treating anxiety.Methods: By adopting a design of multi-centered randomized controlled trial(RCT), a total of 270 patients with anxiety were randomized into a treatment group and a medication group. The treatment group was intervened by music electric stimulation of points, while the medication group was intervened by oral administration of doxepin. The two groups were evaluated by using Hamilton anxiety rating scale(HAMA) and Chinese revised edition of self-rating anxiety scale(SAS-CR)before and after the intervention. The therapeutic efficacies were also compared.Results: The total effective rate was 93.6% in the treatment group versus 92.3% in the medication group, and the between-group difference was statistically insignificant(P>0.05). After the treatment, the aggregate scores of HAMA and SAS-CR were significantly changed in both groups(both P<0.001), and the inter-group differences were statistically insignificant(P>0.05).Conclusion: Music electric stimulation of points can produce equivalent efficacy in treating anxiety compared to doxepin.Thus, it can be taken as a choice in the treatment of anxiety.
Objective: To observe the therapeutic efficacy of music electric stimulation of points in treating anxiety.Methods: By adopting a design of multi-centered randomized controlled trial(RCT), a total of 270 patients with anxiety were randomized into a treatment group and a medication group. The treatment group was intervened by music electric stimulation of points, while the medication group was intervened by oral administration of doxepin. The two groups were evaluated by using Hamilton anxiety rating scale(HAMA) and Chinese revised edition of self-rating anxiety scale(SAS-CR)before and after the intervention. The therapeutic efficacies were also compared.Results: The total effective rate was 93.6% in the treatment group versus 92.3% in the medication group, and the between-group difference was statistically insignificant(P>0.05). After the treatment, the aggregate scores of HAMA and SAS-CR were significantly changed in both groups(both P<0.001), and the inter-group differences were statistically insignificant(P>0.05).Conclusion: Music electric stimulation of points can produce equivalent efficacy in treating anxiety compared to doxepin.Thus, it can be taken as a choice in the treatment of anxiety.
引文
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[15]Xu CL,Wang F,Dong HS.Effect of music electroacupuncture on perifocal ferric ions and neuronal apoptosis percentage and the brain water content in rats with acute cerebral hemorrhage.Shanghai Zhenjiu Zazhi,2017,36(7):840-845.
[16]Tan YT,Yi X,Huang Y,Yuan Q,Liu HH,Yang L.Research progress on music therapy for Broca aphasia.Hunan Zhongyi Zazhi,2016,32(1):169-170.
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[18]Zhang JH.Acupuncture plus auricular point sticking for 24cases with anxiety.Zhongguo Zhen Jiu,2004,24(21):68-69.
[19]Zhang H,Deng H.Observations on the efficacy of acupuncture plus acupuncture point injection in treating post-earthquake generalized anxiety disorder.Shanghai Zhenjiu Zazhi,2010,29(9):576-578.
[2]Kraus SS,Rabin LA.Sleep America:managing the crisis of adult chronic insomnia and associated conditions.JAffect Disord,2012,138(3):192-212.
[3]Milanovic SM1,Erjavec K,Poljinin T,Vrabec B,Brecic P.Prevalence of depression symptoms and associated socio-demographic factors in primary health care patients.Psychiatr Danub,2015,27(1):31-37.
[4]Paykel ES,Brugha T,Fryers T.Size and burden of depressive disorders in Europe.Eur Neuropsychopharmacol,2005,15(4):411-423.
[5]Li AM.Influence of motivated interview on negative emotions and compliance of stroke patients.Zhongguo Linchuang Huli,2014,6(4):328-330.
[6]Wang LP,Li XC,Meng CF,Huang WM,Zhuang XM,Lin GQ.Abnormal glucose metabolism in patients with ischemic stroke.Tongji Daxue Xuebao(Yixue Ban),2014,35(1):73-75.
[7]Liang DS.Effect comparison of music therapy for poststroke depression patients with different syndromes.Qiqihar Yixueyuan Xuebao,2016,37(12):1550-1551.
[8]Psychosis Branch of Chinese Medical Association.The Chinese Classification and Diagnostic Criteria of Mental Disorders.3rd Edition.Jinan:Shandong Technology Press,2001:118-119.
[9]Zhang MY.Psychiatry Assessment Scale Manual.Changsha:Hunan Science&Technology Press,1998:39-42.
[10]Tao M,Gao JF.Reliability and validity of Chinese revised edition of self-rating anxiety scale.Zhongguo Shenjing Jingshen Jibing Zazhi,1994,20(5):301-303.
[11]Hegde S.Music-based cognitive remediation therapy for patients with traumatic brain injury.Music-based cognitive remediation therapy for patients with traumatic brain injury.Front Neurol,2014,5:34.
[12]Sun J,Chen W.Music therapy for coma patients:preliminary results.Eur Rev Med Pharmacol Sci,2015,19(7):1209-1218.
[13]Guétin S,Portet F,Picot MC,PommiéC,Messaoudi M,Djabelkir L,Olsen AL,Cano MM,Lecourt E,Touchon J.Effect of music therapy on anxiety and depression in patients with Alzheimer's type dementia:randomised,controlled study.Dement Geriatr Cogn Disord,2009,28(1):36-46.
[14]Narme P,Clément S,EhrléN,Schiaratura L,Vachez S,Courtaigne B,Munsch F,Samson S.Efficacy of musical interventions in dementia:evidence from a randomized controlled trial.J Alzheimers Dis,2014,38(2):359-369.
[15]Xu CL,Wang F,Dong HS.Effect of music electroacupuncture on perifocal ferric ions and neuronal apoptosis percentage and the brain water content in rats with acute cerebral hemorrhage.Shanghai Zhenjiu Zazhi,2017,36(7):840-845.
[16]Tan YT,Yi X,Huang Y,Yuan Q,Liu HH,Yang L.Research progress on music therapy for Broca aphasia.Hunan Zhongyi Zazhi,2016,32(1):169-170.
[17]Zhang DL,Zhang XM.The interview and treatment of generalized anxiety disorder.Sichuan Jingshen Weisheng,2016,29(2):111-117.
[18]Zhang JH.Acupuncture plus auricular point sticking for 24cases with anxiety.Zhongguo Zhen Jiu,2004,24(21):68-69.
[19]Zhang H,Deng H.Observations on the efficacy of acupuncture plus acupuncture point injection in treating post-earthquake generalized anxiety disorder.Shanghai Zhenjiu Zazhi,2010,29(9):576-578.