异常黏液质型阳痿患者肾上腺轴激素变化及其与常见临床参数的相关性研究
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摘要
目的探讨异常黏液质型阳痿患者肾上腺轴激素变化及其与常见临床参数的相关性,分析其生殖生物学意义。方法选取国际勃起功能指数5项(IIEF-5)评分<22分的阳痿患者112例,在维医辩证分型的基础上分为异常黏液质型阳痿组(A组)和非异常黏液质型阳痿组(B组),并择取健康对照者(N组)28例。采集年龄、身高、体质量、体质指数(BMI)、腰围、血压、脉搏以及男性性欲量表-4(MSF-4)评分,并检测血浆皮质醇(COR)与促肾上腺皮质激素(ACTH)水平。结果 A组COR水平较N组显著升高(P<0.05)。COR水平与IIEF-5、MSF-4呈负相关,与血压呈正相关。结论肾上腺轴激素神经内分泌紊乱可能在异常黏液质型阳痿病证的发生、发展过程中发挥重要作用,其中COR水平与异常黏液质型阳痿患者性欲、勃起功能障碍的严重程度密切相关。
Objective To investigate the hormonal changes of adrenal axis and their correlation to IIEF-5in male impotence disease patients with abnormal phlegmatic syndrome.Methods A total of 112 male impotence disease patients(IIEF-5score<22)were divided into impotence group with abnormal phlegmatic syndrome(A)and impotence group without abnormal phlegmatic syndrome(B)according to Uyghur medicine,and 28 healthy males as the normal control group(N).The age,height,weight,BMI,waist circumference,blood pressure,pulse rate,and MSF-4score were recorded and cortisol and ACTH levels were detected.Results Cortisol level in group A was significantly increased compared to group N,and cortisol level showed a significant correlation to IIEF-5,MSF-4scores and blood pressure.ConclusionHormonal changes of adrenal axis might play an important role in the occurrence and development of impotence disease with abnormal phlegmatic syndrome.Cortisol may become an useful index for the evaluation of sexual function.
Objective To investigate the hormonal changes of adrenal axis and their correlation to IIEF-5in male impotence disease patients with abnormal phlegmatic syndrome.Methods A total of 112 male impotence disease patients(IIEF-5score<22)were divided into impotence group with abnormal phlegmatic syndrome(A)and impotence group without abnormal phlegmatic syndrome(B)according to Uyghur medicine,and 28 healthy males as the normal control group(N).The age,height,weight,BMI,waist circumference,blood pressure,pulse rate,and MSF-4score were recorded and cortisol and ACTH levels were detected.Results Cortisol level in group A was significantly increased compared to group N,and cortisol level showed a significant correlation to IIEF-5,MSF-4scores and blood pressure.ConclusionHormonal changes of adrenal axis might play an important role in the occurrence and development of impotence disease with abnormal phlegmatic syndrome.Cortisol may become an useful index for the evaluation of sexual function.
引文
[1]潘建春.维医异常黏液质型阳痿病证模型建立的实验研究[D].乌鲁木齐:新疆医科大学,2011.
[2]阿地力江·伊明,潘建春,哈木拉提·吾甫尔,等.维医异常黏液质证侯与阳痿病证大鼠模型生殖激素的改变及其生物学意义[J].新疆医科大学学报,2012,35(11):1439-1444.
[3]张盼盼,朱颜刘莹,阿地力江·伊明,等.伊木萨克片对异常黏液质型阳痿病证大鼠模型性腺轴调节作用的形态学研究[J].新疆医科大学学报,2014,37(8):382-286.
[4]AYT I A,MCKINLAY J B,KRANE R J.The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequence[J].BJU Int,1999,84(1):50-56.
[5]刘德风,姜辉,洪锴,等.近5年来中国11个城市门诊勃起功能障碍患者的流行病学变化[J].中华男科学杂志,2009,15(8):724-726.
[6]穆哈穆德爱扎木汗.医科思热爱扎穆[M].乌鲁木齐:新疆人民卫生出版社,2006:1622-1633.
[7]阿卜杜热伊木江·如则,毛吾兰·买买提依明,木萨·艾麦尔,等.维医异常黏液质型阳痿患者常见临床参数和性激素水平变化及相关性研究[J].新疆医科大学学报,2016,39(5):525-529.
[8]张盼盼,刘凤霞,阿地力江·伊明,等.异常黏液质型阳痿病证大鼠性腺轴改变的形态学研究[J].中国男科学杂志,2014,(7):8-13.
[9]MORLEY J E.The diagnosis of late life hypogonadism.[J]Aging Male,2007,10(4):217-220.
[10]DEROUET H,Lehmann J,STAMM B,et al.Age dependent secretion of LH and ACTH in healthy men and patients with erectile dysfunction[J].Eur Urol,2002,41(2):153-154.
[11]SHIRI R,KOSKIMAKI J,TAMMELA T L,et al.Bidirectional relationship between depression and erectile dysfunction[J].J Urol,2007,177(2):669-673.
[12]KUMSTA R,ENTRINGER S,HELLHAMMER D H,et al.Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels[J].Psychoneuroendocrinology,2007,32(8/10):1153-1157.
[13]KOBORI Y,KOH E,SUGINOTO K,et al.The relationship of serum and salivary cortisol levels to male sexual dysfunction as measured by the international index of erectile function[J].Int J Impot Res,2009,21(4):207-212.
[2]阿地力江·伊明,潘建春,哈木拉提·吾甫尔,等.维医异常黏液质证侯与阳痿病证大鼠模型生殖激素的改变及其生物学意义[J].新疆医科大学学报,2012,35(11):1439-1444.
[3]张盼盼,朱颜刘莹,阿地力江·伊明,等.伊木萨克片对异常黏液质型阳痿病证大鼠模型性腺轴调节作用的形态学研究[J].新疆医科大学学报,2014,37(8):382-286.
[4]AYT I A,MCKINLAY J B,KRANE R J.The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequence[J].BJU Int,1999,84(1):50-56.
[5]刘德风,姜辉,洪锴,等.近5年来中国11个城市门诊勃起功能障碍患者的流行病学变化[J].中华男科学杂志,2009,15(8):724-726.
[6]穆哈穆德爱扎木汗.医科思热爱扎穆[M].乌鲁木齐:新疆人民卫生出版社,2006:1622-1633.
[7]阿卜杜热伊木江·如则,毛吾兰·买买提依明,木萨·艾麦尔,等.维医异常黏液质型阳痿患者常见临床参数和性激素水平变化及相关性研究[J].新疆医科大学学报,2016,39(5):525-529.
[8]张盼盼,刘凤霞,阿地力江·伊明,等.异常黏液质型阳痿病证大鼠性腺轴改变的形态学研究[J].中国男科学杂志,2014,(7):8-13.
[9]MORLEY J E.The diagnosis of late life hypogonadism.[J]Aging Male,2007,10(4):217-220.
[10]DEROUET H,Lehmann J,STAMM B,et al.Age dependent secretion of LH and ACTH in healthy men and patients with erectile dysfunction[J].Eur Urol,2002,41(2):153-154.
[11]SHIRI R,KOSKIMAKI J,TAMMELA T L,et al.Bidirectional relationship between depression and erectile dysfunction[J].J Urol,2007,177(2):669-673.
[12]KUMSTA R,ENTRINGER S,HELLHAMMER D H,et al.Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels[J].Psychoneuroendocrinology,2007,32(8/10):1153-1157.
[13]KOBORI Y,KOH E,SUGINOTO K,et al.The relationship of serum and salivary cortisol levels to male sexual dysfunction as measured by the international index of erectile function[J].Int J Impot Res,2009,21(4):207-212.