复方红芪促睡眠颗粒剂制备工艺研究
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摘要
目的:确定复方红芪促睡眠颗粒剂的制备工艺。方法:以正交实验法优选复方红芪促睡眠颗粒剂的最佳提取工艺条件,以最佳提取工艺条件进行制剂工艺研究。结果:取处方量的复方红芪方中药,加10倍水煎煮3次,l.5 h/次,合并煎液,静置,滤过,煎煮浓缩至相对密度为1.25~1.30(60℃)的稠膏,减压干燥(70℃),得到干膏粉。干膏粉和糊精按1∶1.5混合均匀后以85%乙醇溶液为湿润剂制成颗粒,干燥,即得。结论:该制备方法简单可行,所得制剂质量稳定,可作为复方红芪促睡眠颗粒剂的制备工艺。
Objective: To confirm the preparation process of compound Hong Qi(manyinflorescenced sweetvetch root) boosting-sleep granules. Methods: The best extraction conditions of compound Hong Qi boosting-sleep granules were optimized by orthogonal test, and the preparation technology was studied under the best extraction technology conditions. Results: The herbs were measured and selected according to compound Hong Qi prescription,after adding ten times water, the herbs were decocted for three times, 1.5 hours each time, decoction was merged,left to stand, filtrated, decocted to the thick paste in the relative density of 1.25~1.30(60℃), decompressed and dryied(70℃), to obtain dry paste powder. Dry paste powder and dextrine were mixed well in the ratio of 1: 1.5, and85% ethanol solution was taken as the wetting agent to granulate and dry. Conclusion: The preparation method, simple and feasible with stable preparations, could be used to produce compound Hong Qi boosting-sleep granules.
Objective: To confirm the preparation process of compound Hong Qi(manyinflorescenced sweetvetch root) boosting-sleep granules. Methods: The best extraction conditions of compound Hong Qi boosting-sleep granules were optimized by orthogonal test, and the preparation technology was studied under the best extraction technology conditions. Results: The herbs were measured and selected according to compound Hong Qi prescription,after adding ten times water, the herbs were decocted for three times, 1.5 hours each time, decoction was merged,left to stand, filtrated, decocted to the thick paste in the relative density of 1.25~1.30(60℃), decompressed and dryied(70℃), to obtain dry paste powder. Dry paste powder and dextrine were mixed well in the ratio of 1: 1.5, and85% ethanol solution was taken as the wetting agent to granulate and dry. Conclusion: The preparation method, simple and feasible with stable preparations, could be used to produce compound Hong Qi boosting-sleep granules.
引文
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[2]李外,张雪伟.酸枣仁粉碎前后对酸枣仁皂苷A含量和安神功效的影响[J].中国中医药信息杂志,2008,15(11):39-41.
[3]胡贞贞,蔡震宇,朱俊,等.酸枣仁甲醇提取物促进日间快动眼睡眠的机制研究[J].南京中医药大学学报,2013,29(3):238-242.
[4]刘世军,唐志书,崔春利,等.酸枣仁化学成分的研究进展[J].西部中医药,2016,29(9):143-146.
[5]张舜波,王平,田代志,等.酸枣仁总皂苷对失眠老年大鼠脑氨基酸类神经递质及受体表达的影响[J].中国实验方剂学杂志,2014,4(20):124-127.
[6]金珠娜.细叶远志镇静作用的化学成分的研究[D].武汉:湖北中医药大学,2011.
[7]白灵,冯玛莉,宋美卿,等.七种果实类中药镇静催眠作用比较[J].中国中医药咨讯,2011,3(5):25-26.
[8]邓少玲.石莲女贞汤治疗顽固性失眠30例[J].新中医,2002,34(8):57-58.
[9]张雄飞,竹建平.白芍提取物对小鼠改善睡眠的影响[J].当代医学,2008(142):33-34.
[10]夏璇,黄清春.白芍总苷联合柳氮磺胺吡啶治疗强直性脊柱炎的疗效观察[J].中国误诊学杂志,2010,10(29):7064-7065.
[11]李越峰,李廷利.四逆散中主要有效成分芍药苷对睡眠影响的实验研究[J].2011,33(4):690-692.
[12]张立峰,刘灿仿,徐福鹏.基于中医传承辅助系统的含酸枣仁治疗失眠组方规律分析[J].西部中医药,2016,29(9):96-99.
[13]阮红,吕志良.女贞子多糖免疫调节作用研究[J].中国中药杂志,1999,24(11):691-693.
[14]崔豪,冯静,崔瑛,等.熟地黄及其多糖中枢抑制作用研究[J].河南中医学院学报,2006,21(6):18-19.
[15]沙沂,李文,张艳.远志的镇静催眠作用活性成分提取工艺研究[J].中成药,2005,27(6):728-730.
[16]钟洁雯,陈建伟,李祥,等.中药牡蛎对戊巴比妥钠催眠作用的影响[J].中华中医药学刊,2009,27(3):499-501.
[17]朱燕飞.枸杞子药理作用概述[J].浙江中西医结合杂志,2005,15(5):322-323.
[18]罗友华,黄亦琦,杨辉,等.中药颗粒剂辅料的研究进展[J].海峡药学,2002,14(1):1-3.