牡丹花化学成分研究
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摘要
对毛茛科芍药属植物牡丹的花瓣化学成分进行研究。运用多种色谱方法进行分离纯化,运用~1H NMR、~(13)C NMR和MS波谱学数据鉴定其结构。结果得到7个单萜糖苷类化合物,分别为吡啶芍药苷(1)、paeodanin B(2)、芍药新苷(3)、乙酰芍药苷(4)、芍药苷(5)、苯甲酰芍药苷(6)和氧化芍药苷(7),及2个酚酸类化合物,分别为没食子酸(8)和没食子酸甲酯(9)。化合物1~7均首次从牡丹花中分离得到。
Seven paeoniflorin-related monoterpene glycosides,namely pyridylpaeoniflorin(1),paeodanin B( 2),lactiflorin( 3),acetylpaeoniflorin( 4),paeoniflorin( 5),benzoyl paeoniflorin( 6),oxypaeoniflorin( 7) as well as two phenoic acids,namely gallic acid( 8) and methyl gallate( 9) were isolated from the flower petals of Paeonia suffruticosa Andr. by various chromatographic methods. Their structures were identified by ~1H NMR,~(13)C NMR and MS spectral analysis. Compounds 1-7 were obtained from the flowers of P. suffruticosa for the first time.
Seven paeoniflorin-related monoterpene glycosides,namely pyridylpaeoniflorin(1),paeodanin B( 2),lactiflorin( 3),acetylpaeoniflorin( 4),paeoniflorin( 5),benzoyl paeoniflorin( 6),oxypaeoniflorin( 7) as well as two phenoic acids,namely gallic acid( 8) and methyl gallate( 9) were isolated from the flower petals of Paeonia suffruticosa Andr. by various chromatographic methods. Their structures were identified by ~1H NMR,~(13)C NMR and MS spectral analysis. Compounds 1-7 were obtained from the flowers of P. suffruticosa for the first time.
引文
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2 Lin HC,Ding HY,Ko FN,et al.Aggregation inhibitory activity of minor acetophenones from Paeoniaspecies.Planta Med,1999,65:595-599.
3 Yoshikawa M,Ohta T,Kawaguchi A,et al.Bioactive constituents of Chinese natural medicines.V.Radicalscavenging effect of moutan cortex.(1):absolute stereostructures of two monoterpenes,paeonisuffone and paeonisuffal.Chem Pharm Bull,2000,48:1327-1331.
4 Wang X,Cheng C,Sun Q,et al.Isolation and identification of four flavonoid constituents from the flowers of Paeonia Suffruticosa by high-speed counter-current chromatography.J Chromatogr A,2005,1075:127-131.
5 Fan JL,Zhu WX,Kang HB,et al.Flavonoid constituents and antioxidant capacity in flowers of different Zhongyuan tree pennycultivars.J Funct Foods,2012:147-157.
6 He HN,Zhang YC,Peng Y,et al.Monoterpene glycosides from the seeds of Paeonia suffruticosa protect HEK 293 cells from irradiation-induced DNA damage.Phytochemistry Lett,2012,5:128-133.
7 Ding LQ,Zhao F,Chen LX,et al.New monoterpeneglycosides from Paeonia suffruticosa Andrews and theirinhibition on NO production in LPS-induced RAW 264.7cells.Bioorg Med Chem Lett,2012,22:7243-7247.
8 Lang HY,Li SZ,Wang HB,et al.The structure of lactiflorin,an artefact during isolation.Tetrahedron,1990,46:3123-3128.
9 Zhang XY(张晓燕).A study on the chemical constituents of Paeonia Lactiflora Pall.Shenyang:Shenyang Pharmaceutical University(沈阳药科大学),MSc.2001.
10 Wang Q(王巧),Guo HZ(郭洪祝),Huo CH(霍长虹),et al.Chemical constituents in root of Paeonia lactiflora.Chin Tradit Herb Drugs(中草药),2007,38:972-976.
11 Wu SH(吴少华),Chen YW(陈有为),Yang LY(杨丽源),et al.Chemical constituents of Paeonia veitchii.Chin Tradit Herb Drugs(中草药),2008,39:13-15.
12 Wang WX(王文祥),Jiang XG(蒋小岗),Gu M(顾明),et al.Study on the chemical constituents from Paeonia Lactiflora.Nat Prod Res Dev(天然产物研究与开发),2000,12:37-38.
13 Sadtler R Lab.Sadtler Standard NMR Spectra.Philadelphia:SadtlerRLab Inc,1971,10229.
14 Qi SH(漆淑华),Guo JW(郭建伟),Wu DG(吴大刚),et al.Study on the chemical constituents of Ostodes paniculata.Nat Prod Res Dev(天然产物研究与开发),2004,16:210-212.