金银花超微粉与普通粉重复给药的安全性比较研究
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摘要
旨在观察金银花超微粉与普通粉对大鼠的长期毒性,为临床安全用药提供科学依据。将Wistar大鼠140只,随机分为7组,即对照组,金银花超微粉低、中、高剂量组,金银花普通粉低、中、高剂量组。连续灌胃4周,分别于末次给药后及停药2周后,测定大鼠血液学、血液生化学、脏器系数、病理组织学变化。结果表明,给药期间各组大鼠血液学、血液生化学及脏器系数无异常变化,停药2周后,上述指标均正常。结果显示,给药期及恢复期重要脏器病理组织检查均未发现明显异常。说明金银花超微粉与传统粉重复用药对大鼠未见明显毒性反应,长期服用安全。
To observe the long-term toxicity of honeysuckle superfine powder and common powder in rats,provide scientific basis for clinical safety medication,140 Wistar rats were randomly divided into 7 groups:control group,honeysuckle superfine powder and honeysuckle common powder low,medium,high dose groups.After 4 weeks of continuous administration,hematology,blood biochemistry,organ coefficients,histopathological lesions were measured after the last administration and after 2 weeks of withdrawal.There were no abnormal changes in hematology,blood biochemistry and organ coefficients of rats during the administration period.After 2 weeks of withdrawal,all above indexes were normal.There was no obvious abnormality in the pathological examination of vital organs in the medication and recovery periods.Long-term medication of honeysuckle superfine powder and common powder have no obvious toxicity,and they are safe.
To observe the long-term toxicity of honeysuckle superfine powder and common powder in rats,provide scientific basis for clinical safety medication,140 Wistar rats were randomly divided into 7 groups:control group,honeysuckle superfine powder and honeysuckle common powder low,medium,high dose groups.After 4 weeks of continuous administration,hematology,blood biochemistry,organ coefficients,histopathological lesions were measured after the last administration and after 2 weeks of withdrawal.There were no abnormal changes in hematology,blood biochemistry and organ coefficients of rats during the administration period.After 2 weeks of withdrawal,all above indexes were normal.There was no obvious abnormality in the pathological examination of vital organs in the medication and recovery periods.Long-term medication of honeysuckle superfine powder and common powder have no obvious toxicity,and they are safe.
引文
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[3]蔡光先,杨永华,李跃辉.超微粉体技术与中药饮片改革[J].世界科学技术,2004,6(2):67-70,87.
[4]王鹏军.单味中药超微饮片的研制与开发探讨[J].当代医药论丛,2014,12(13):179.
[5]张红刚,汪妮,李顺祥,等.超微粉碎技术对中药有效成分提取效果影响研究[J].广州化工,2013,41(16):63-65.
[6]申玲玲,杜光,郭俊浩.超微粉碎对中药活性成分溶出度的影响[J].中国医院药学杂志,2011,31(14):1213-1214,1230.
[7]马喜军.超微饮片与传统饮片保和丸治疗小儿厌食症效果对比研究[J].社区医学杂志,2014,12(2):11-13.
[8]张祥伟.中药超微饮片与传统饮片化学成分及药效学剂量对比研究[D].广东广州:南方医科大学,2010.
[9]袁超.中药超微饮片的成分组成与原药材成分的差异分析[J].中国医药指南,2013,11(12):79-80.
[10]汪文涛.中药超微饮片质量控制与安全性探讨[J].世界科学技术,2004,6(3):37-40,54-86.
[11]谭文.黄连超微饮片的成分组成与原药材成分的差异分析[J].求医问药,2012,10(11):838-839.
[12]彭安堂,张桂侠,赵玉斌,等.超微粉碎中药的安全性思考[J].中国医院药学杂志,2015,35(21):1973-1976.
[13]蔡光先.超微中药的临床有效性与安全性研究及其思考[J].中华中医药学刊,2010,28(9):1801-1804.
[14]蔡光先,李勇敏,郑兵,等.中药超微饮片量效关系及安全性初探[J].中国新药杂志,2007,16(9):682-684.
[15]蔡光先.超微中药的研究与应用及前景展望[J].世界中医药,2011,6(01):78-81.
[16]谢云亮.五味子有效成分分离纯化及对记忆障碍模型小鼠学习记忆的影响[D].吉林长春:吉林大学,2013.