曲美布汀联合多塞平、培菲康治疗慢性胃肠功能紊乱的效果观察
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摘要
目的观察慢性胃肠功能紊乱应用曲美布汀、多塞平、培菲康联合治疗的效果。方法随机将在本院治疗的104例慢性胃肠功能紊乱患者分为研究组和对照组,每组52例,研究组给予曲美布汀、多塞平、培菲康联合治疗,对照组给予谷维素、多塞平、培菲康联合治疗,观察两组患者的临床治疗效果、临床症状消失时间及不良反应发生情况。结果研究组的治疗总有效率(96.2%)高于对照组(82.7%)(P<0.05);研究组上腹痛、腹胀、早饱、嗳气、恶心等症状消失时间均短于对照组(P<0.05);两组患者不良反应发生率比较,差异不显著(P>0.05)。结论慢性胃肠功能紊乱应用曲美布汀、多塞平、培菲康联合治疗时,效果良好,不良反应少。
Objective To observe the effect of trimebutine combined with doxepin and bifico in the treatment of chronic gastrointestinal disorders. Methods One hundred and four patients with chronic gastrointestinal disorders were randomly divided into study group and control group, with 52 cases in each group. The study group was given trimebutine combined with doxepin and bifico treatment, and the control group was given oryzanol combined with doxepin and bifico treatment.The clinical effect, disappearance time of clinical symptoms and adverse reactions were observed in the two groups. Results The total effective rate of the study group(96.2%) was higher than that of the control group(82.7%)(P <0.05). The disappearance times of clinical symptoms such as abdominal pain, abdominal distension, early satiety, belching, nausea in the study group were shorter than those in the control group(P<0.05). There was no significant difference between the two groups in the incidence rate of adverse reactions(P >0.05). Conclusion The trimebutine, doxepin and bifico has a good therapeutic effect and few adverse reactions chronic gastrointestinal disorders.
Objective To observe the effect of trimebutine combined with doxepin and bifico in the treatment of chronic gastrointestinal disorders. Methods One hundred and four patients with chronic gastrointestinal disorders were randomly divided into study group and control group, with 52 cases in each group. The study group was given trimebutine combined with doxepin and bifico treatment, and the control group was given oryzanol combined with doxepin and bifico treatment.The clinical effect, disappearance time of clinical symptoms and adverse reactions were observed in the two groups. Results The total effective rate of the study group(96.2%) was higher than that of the control group(82.7%)(P <0.05). The disappearance times of clinical symptoms such as abdominal pain, abdominal distension, early satiety, belching, nausea in the study group were shorter than those in the control group(P<0.05). There was no significant difference between the two groups in the incidence rate of adverse reactions(P >0.05). Conclusion The trimebutine, doxepin and bifico has a good therapeutic effect and few adverse reactions chronic gastrointestinal disorders.
引文
[1]刘慧敏,陈富超,朱雪松,等.国内曲美布汀联用氟哌噻吨美利曲辛治疗肠易激综合征疗效和安全性的Meta分析[J].安徽医药,2013,17(12):2125-2128.
[2]杨卓.马来酸曲美布汀联合培菲康治疗肠易激综合征临床疗效观察[J].中国实用医药,2013,8(35):143-144.
[3]李向玮,梁仲惠.抗抑郁药治疗功能性胃肠病的现状[J].胃肠病学和肝病学杂志,2013,22(12):1281-1284.
[4]戚红亮.曲美布汀联合穴位针刺治疗腹泻型肠易激综合征的疗效观察[J].现代消化及介入诊疗,2014,24(1):57-59.
[5]牛宏立.盐酸多塞平治疗功能性胃肠病的疗效观察[J].河南科技大学学报:医学版,2014,32(1):25-27.
[6]王菁.曲美布汀联合黛力新治疗Ⅱ型糖尿病胃肠功能紊乱临床疗效观察[J].西部医学,2014,17(7):896-898.
[7]徐玉梅,金桂兰,任习芳.马来酸曲美布汀联合盐酸多塞平治疗功能性消化不良伴抑郁症的临床观察[J].中国药房,2014,17(40):3786-3788.
[8]吕先佑.Ⅱ型糖尿病诱发胃肠功能紊乱应用黛力新及曲美布汀的临床研究[J].数理医药学杂志,2016,16(7):1046-1047.
[9]孙海丰.马来酸曲美布汀联合益生菌制剂治疗糖尿病性腹泻的效果及对胃肠动力学的影响分析[J].糖尿病新世界,2016,19(19):39-40.
[10]孙雪飞,何旭.马来酸曲美布汀联合培菲康治疗胃肠功能紊乱疗效观察[J].实用中西医结合临床,2013,13(9):28-29.
[2]杨卓.马来酸曲美布汀联合培菲康治疗肠易激综合征临床疗效观察[J].中国实用医药,2013,8(35):143-144.
[3]李向玮,梁仲惠.抗抑郁药治疗功能性胃肠病的现状[J].胃肠病学和肝病学杂志,2013,22(12):1281-1284.
[4]戚红亮.曲美布汀联合穴位针刺治疗腹泻型肠易激综合征的疗效观察[J].现代消化及介入诊疗,2014,24(1):57-59.
[5]牛宏立.盐酸多塞平治疗功能性胃肠病的疗效观察[J].河南科技大学学报:医学版,2014,32(1):25-27.
[6]王菁.曲美布汀联合黛力新治疗Ⅱ型糖尿病胃肠功能紊乱临床疗效观察[J].西部医学,2014,17(7):896-898.
[7]徐玉梅,金桂兰,任习芳.马来酸曲美布汀联合盐酸多塞平治疗功能性消化不良伴抑郁症的临床观察[J].中国药房,2014,17(40):3786-3788.
[8]吕先佑.Ⅱ型糖尿病诱发胃肠功能紊乱应用黛力新及曲美布汀的临床研究[J].数理医药学杂志,2016,16(7):1046-1047.
[9]孙海丰.马来酸曲美布汀联合益生菌制剂治疗糖尿病性腹泻的效果及对胃肠动力学的影响分析[J].糖尿病新世界,2016,19(19):39-40.
[10]孙雪飞,何旭.马来酸曲美布汀联合培菲康治疗胃肠功能紊乱疗效观察[J].实用中西医结合临床,2013,13(9):28-29.