黄琳教授治疗冠心病室性早搏用药规律探讨
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摘要
目的通过数据挖掘方法回顾性分析黄琳教授治疗冠心病室性早搏的用药规律,为临床心悸的中医治疗提供更多思路。方法收集2017年1月至2018年1月广东省第二中医院75例心血管门诊及住院患者245份电子病历,采用频数、频率分析以及层次聚类分析等方法进行药物分析。结果有9味中药频率超过50.00%,11种频率在20.00%～50.00%之间,13味频率小于20.00%,根据聚类分析,33味中药可分为5大类。结论黄琳教授治疗冠心病室性早搏以心脏的生理特点为依据,主要从心脏论治,辅以水火并济、疏肝理气、活血化瘀祛痰。
Objective: To analyze the Chinese medication regularity and experience of professor Huang Lin on coronary heart disease with ventricular premature beat,and provide more ideas for clinical treatment. Methods:75 cases including 245 electronic medical records for coronary heart disease with ventricular premature beat treated by professor Huang from January 2017 to January 2018 were collected. Frequency analysis,relative frequency analysis,and Hierarchical Cluster analysis were used to analyze and evaluate the Chinese medicine regularity. Result: 9 herbs were used with a frequency over 50.00%,11 ones between 20.00% and 50.00%,and 13 ones below 20.00%. Moreover,these 33 herbs could be divided into 5 types with Hierarchical Cluster analysis.Conclusion: The regularity of Chinese medication of professor Huang for coronary heart disease with ventricular premature beat is based on the physiological characteristics of the heart,and focuses on the heart-regulating,kidney-tonifying and liver-soothing therapy with combination of promoting blood circulation to remove blood stasis.
Objective: To analyze the Chinese medication regularity and experience of professor Huang Lin on coronary heart disease with ventricular premature beat,and provide more ideas for clinical treatment. Methods:75 cases including 245 electronic medical records for coronary heart disease with ventricular premature beat treated by professor Huang from January 2017 to January 2018 were collected. Frequency analysis,relative frequency analysis,and Hierarchical Cluster analysis were used to analyze and evaluate the Chinese medicine regularity. Result: 9 herbs were used with a frequency over 50.00%,11 ones between 20.00% and 50.00%,and 13 ones below 20.00%. Moreover,these 33 herbs could be divided into 5 types with Hierarchical Cluster analysis.Conclusion: The regularity of Chinese medication of professor Huang for coronary heart disease with ventricular premature beat is based on the physiological characteristics of the heart,and focuses on the heart-regulating,kidney-tonifying and liver-soothing therapy with combination of promoting blood circulation to remove blood stasis.
引文
[1]张萍,李博,徐凤芹,等.中医药治疗冠心病室性早搏的系统评价[J].中西医结合心脑血管病杂志,2012,10(12):1409-1411.
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[9]王国刚,郑道国,颜安华.桂枝甘草龙骨牡蛎加味汤联合丹参多酚酸盐注射液治疗冠心病室性早搏临床观察[J].新中医,2015,47(11):31-33.
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[12]席管劳.滋肾定悸汤治疗更年期女性阴虚火旺型心悸49例[J].西部中医药,2016,29(6):65-66.
[13]华愫.华明珍教授从肾论治心悸的经验[J].中国中医药现代远程教育,2011,9(9):15-16.
[14]谭斌,刘韵,谷彬.瓜蒌皮提取物对大鼠血管内皮损伤的保护作用[J].中国现代医药杂志,2009,12(9):9-11.
[15]张晓庆,王海军.瓜蒌薤白半夏汤改善痰浊闭阻型胸痹心痛患者胸闷、心悸等中医证候的临床研究[J].中西医结合心血管病电子杂志,2016,4(11):69-70.
[16]李艳,罗淑梅,董雅华.血府逐瘀汤治疗冠心病50例疗效观察[J].中国现代药物应用,2009,3(3):94-95.
[17]李凤娥,王清贤.柴胡加龙骨牡蛎汤治疗肝郁气滞型心悸56例[J].中国中医急症,2013,22(1):137-138.
[18]郑晔,钱苏瑜,游自立.酸枣仁药理作用研究进展[J].四川生理科学杂志,2006,28(1):35-37.
[2]周凤华,黄志勇,陈磊,等.中药治疗冠心病室性早搏随机对照试验的系统评价[J].热带医学杂志,2012,12(9):1086-1090.
[3]中华人民共和国卫生部.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[4]元柏民.心血管病诊断标准[M].北京:学苑出版社,1991.
[5]葛均波,徐永健.内科学[M].北京:人民卫生出版社,2013:177-178.
[6]钱慕仪.抗心律失常药研究新进展[J].当代医学,2010,16(4):22-24.
[7]杨丽红,谢秀琼,万丽,等.川芎化学成分研究[J].时珍国医国药,2007,18(7):33-34.
[8]郑丰杰.《伤寒论》辨治心阳虚三方证治解析[J].北京中医药大学学报,2016,39(12):973-977.
[9]王国刚,郑道国,颜安华.桂枝甘草龙骨牡蛎加味汤联合丹参多酚酸盐注射液治疗冠心病室性早搏临床观察[J].新中医,2015,47(11):31-33.
[10]李静,陈宝田.柴胡加龙骨牡蛎汤的现代应用和研究[J].中华实用中西医杂志,2006,19(18):2221.
[11]单连荣,陈艳玲.黄芪药理研究与临床应用[J].黑龙江科技信息,2014,18(1):32.
[12]席管劳.滋肾定悸汤治疗更年期女性阴虚火旺型心悸49例[J].西部中医药,2016,29(6):65-66.
[13]华愫.华明珍教授从肾论治心悸的经验[J].中国中医药现代远程教育,2011,9(9):15-16.
[14]谭斌,刘韵,谷彬.瓜蒌皮提取物对大鼠血管内皮损伤的保护作用[J].中国现代医药杂志,2009,12(9):9-11.
[15]张晓庆,王海军.瓜蒌薤白半夏汤改善痰浊闭阻型胸痹心痛患者胸闷、心悸等中医证候的临床研究[J].中西医结合心血管病电子杂志,2016,4(11):69-70.
[16]李艳,罗淑梅,董雅华.血府逐瘀汤治疗冠心病50例疗效观察[J].中国现代药物应用,2009,3(3):94-95.
[17]李凤娥,王清贤.柴胡加龙骨牡蛎汤治疗肝郁气滞型心悸56例[J].中国中医急症,2013,22(1):137-138.
[18]郑晔,钱苏瑜,游自立.酸枣仁药理作用研究进展[J].四川生理科学杂志,2006,28(1):35-37.