鹿茸补骨片的配伍药效学研究
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摘要
目的验证鹿茸补骨片中不同药物配伍对卵巢摘除大鼠骨密度的影响。方法制备马鹿茸-熟地黄、马鹿茸-黄芪、马鹿茸-熟地黄-骨碎补、马鹿茸-黄芪-骨碎补、马鹿茸-熟地黄-黄芪-骨碎补配伍的混悬液,实验设空白对照组、模型组、雌激素组,每组10只动物,设高、低剂量组,灌胃给药,考察大鼠体质量及子宫湿重(mg)。结果马鹿茸-熟地黄-黄芪-骨碎补高、低剂量组与空白对照组及模型组相比均有极显著差异(p <0.01),且对子宫湿重影响最大。结论鹿茸补骨片对卵巢摘除大鼠骨密度降低有明显改善作用。
Objective To verify the effect of different drugs in Lurong Bugu pill on bone mineral density in ovariectomized rats. Methods The suspension of pilose antler-prepared rehmannia root,pilose antler-astragalus root,pilose antler-prepared rehmannia root-drynaria rhizome, pilose antler-astragalus root-drynaria rhizome, and pilose antler-prepared rehmannia root-astragalus root-drynaria rhizome was prepared. The experiment consisted of a blank control group, a model group and an estrogen group with 10 animals in each group. The rats' body weight and uterus wet weight(mg) were measured by gavage. Results The high and low dose groups of pilose antler + radix rehmanniae preparata + radix astragali + Rhizoma drynariae were significantly different from the blank control group and model group(P < 0.01), and had the greatest impact on the wet weight of uterus. Conclusion Lurong Bugu pill can significantly improve bone mineral density in ovariectomized rats.
Objective To verify the effect of different drugs in Lurong Bugu pill on bone mineral density in ovariectomized rats. Methods The suspension of pilose antler-prepared rehmannia root,pilose antler-astragalus root,pilose antler-prepared rehmannia root-drynaria rhizome, pilose antler-astragalus root-drynaria rhizome, and pilose antler-prepared rehmannia root-astragalus root-drynaria rhizome was prepared. The experiment consisted of a blank control group, a model group and an estrogen group with 10 animals in each group. The rats' body weight and uterus wet weight(mg) were measured by gavage. Results The high and low dose groups of pilose antler + radix rehmanniae preparata + radix astragali + Rhizoma drynariae were significantly different from the blank control group and model group(P < 0.01), and had the greatest impact on the wet weight of uterus. Conclusion Lurong Bugu pill can significantly improve bone mineral density in ovariectomized rats.
引文
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[14]郭金弟,冯伟镜,高明,等.不同部位骨密度与胸主动脉钙化的相关性研究[J].岭南急诊医学杂志, 2017, 22(5):439-442.
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[17]张洁文,冯绍文,陈少珍.健骨汤辅助治疗对骨质疏松性胸腰椎压缩性骨折患者椎体成形术后骨折愈合的影响[J].中药材, 2017, 40(8):1972-1974.
[18]李斌,曹金霞,王保森,等.鹿茸多肽提取物抗去卵巢大鼠骨质疏松作用的研究[J].吉林中医药, 2017, 37(3):276-280.
[19]欧莉,左杨洁,陈佳利,等.熟地配伍黄芪对去卵巢大鼠骨组织及骨骼肌氧化应激状态的影响[J].现代中医药,2018, 38(3):90-92, 98.
[20]张新涛,江华基,梁祖儒,等.骨碎补总黄酮通过激活mTOR信号通路促进大鼠腱骨愈合的实验研究[J].中国骨伤, 2018, 31(3):248-253.
[2]翁绳健,吴立忠,李炜明,等.肾虚与骨质疏松症关联性研究进展[J].中国中医骨伤科杂志, 2018, 26(12):85-88.
[3]王勇朋,阳琰,何生生,等.不同重建层厚对定量CT椎体骨密度测量值的影响[J].放射学实践, 2018, 33(11):1191-1193.
[4]饶良芳.早期护理干预模式在改善婴儿骨密度方面的价值研究[J].全科护理, 2018, 16(30):3779-3780.
[5]公璐璐.中老年体成分与骨密度的关系[J].运动精品,2018, 37(7):74-78.
[6]张燕敏,胡慧雯.东部沿海地区中老年居民骨密度现状调查及影响因素分析[J].中国现代医生, 2018, 56(29):132-134.
[7]陈杨畅,李素蘋,项光博,等.前臂骨密度测定诊断绝经后类风湿关节炎合并骨质疏松的价值[J].浙江医学, 2018,40(22):2466-2469.
[8]李静,赵海萍,吴文军,等.银川市中小学生骨密度和骨矿含量[J].中国学校卫生, 2017, 38(6):885-887.
[9]郑煜晖,吴世强,庄华峰.老年骨质疏松患者骨代谢指标、骨密度与骨质疏松性骨折的相关性[J].中国老年学杂志,2017, 37(23):5920-5922.
[10]张哲,徐秀娟,刘欣,等.老鹳草素治疗去卵巢小鼠骨质疏松症的实验研究[J].河北医药, 2017, 39(24):3685-3688.
[11]陈冠儒,陈飞虎,葛金芳,等.葛根总黄酮对去势大鼠骨质疏松的保护作用[J].安徽医科大学学报, 2014, 49(6):759-764.
[12]宋静荣.益母草总黄酮对去卵巢大鼠下丘脑和海马雌激素受体α及βmRNA表达的影响[J].北华大学学报(自然科学版), 2014, 15(6):747-749.
[13]郑小花,黄惠娟,李宝恒,等.左归丸联合橄榄油对大鼠去势后骨质疏松症的选择性作用[J].中国妇幼保健,2014, 29(5):798-801.
[14]郭金弟,冯伟镜,高明,等.不同部位骨密度与胸主动脉钙化的相关性研究[J].岭南急诊医学杂志, 2017, 22(5):439-442.
[15]刘悦,顾海峰.骨质疏松症患者骨密度与血清激素水平的关系[J].中华全科医学, 2017, 15(12):2086-2088.
[16]李珏东,范忠庆,卢陈勇.补肾健脾汤辅佐西药治疗老年性骨质疏松的效果及对骨密度的影响[J].内蒙古中医药,2017, 36(Z1):105-106.
[17]张洁文,冯绍文,陈少珍.健骨汤辅助治疗对骨质疏松性胸腰椎压缩性骨折患者椎体成形术后骨折愈合的影响[J].中药材, 2017, 40(8):1972-1974.
[18]李斌,曹金霞,王保森,等.鹿茸多肽提取物抗去卵巢大鼠骨质疏松作用的研究[J].吉林中医药, 2017, 37(3):276-280.
[19]欧莉,左杨洁,陈佳利,等.熟地配伍黄芪对去卵巢大鼠骨组织及骨骼肌氧化应激状态的影响[J].现代中医药,2018, 38(3):90-92, 98.
[20]张新涛,江华基,梁祖儒,等.骨碎补总黄酮通过激活mTOR信号通路促进大鼠腱骨愈合的实验研究[J].中国骨伤, 2018, 31(3):248-253.