瑞舒伐他汀对老年CHD患者LVE和EDD的疗效
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摘要
目的探讨瑞舒伐他汀对老年冠状动脉粥样硬化性心脏病(CHD)患者左心室功能(LVE)和内皮舒张功能(EDD)的临床疗效。方法随机抽取合阳县医院收治的心功能不全伴不稳定心绞痛老年患者160例进行回顾性分析,根据降血脂药物的选择不同分为2组,即常规组和瑞舒伐他汀组,在治疗前、治疗后3 d、1周、1个月、3个月、6个月测定患者的2组患者左心室射血分数(LVEF)、左心室高峰充盈率(LVPFR)、内皮依赖性舒张功能(EDD)、非内皮依赖性舒张功能(NEDD)。结果 2组患者治疗后左心室功能比较显示,瑞舒伐他汀组在治疗后1个月、3个月、6个月的LVEF、LVPFR大于常规组,并且治疗后1个月、3个月、6个月的LVEF、LVPFR大于治疗前,差异均有统计学意义(P<0.05)。2组患者治疗后血管内皮功能比较显示,瑞舒伐他汀组在治疗后1个月、3个月、6个月的EDD、NEDD大于常规组,并且治疗后1个月、3个月、6个月的EDD、NEDD大于治疗前,差异均有统计学意义(P<0.05)。LVEF和EDD、NEDD的Pearson相关性显示,LVEF和EDD、NEDD呈正相关(r=0.741、0.736,P=0.036、0.014)。结论瑞舒伐他汀对老年CHD患者LVE和EDD有一定改善作用。
Objective To observe the therapeutic effects of rosuvastatin on left ventricular function( LVF) and endothelium diastolic function( EDF) in elderly patients with coronary heart disease( CHD). Methods One hundred and sixty patients with cardiac insufficiency complicated by unstable angina who were treated in Heyang County Hospital were enrolled in the study. According to different antilipemic agents,the patients were divided into conventional therapy group and rosuvastatin group. The left ventricular ejection fraction( LVEF),left ventricular peak filling rate( LVPFR),endotheliumdependent diastolic function( EDD),non-endothelium-dependent diastolic function( NEDD) were detected before treatment,on 3d,1w,1m,3m,6m after treatment for both groups. Results The LVEF and LVPFR in rosuvastatin group on 1m,3m,6m after treatment were significantly higher than those in conventional therapy group,moreover,which were significantly higher than those before treatment( P < 0. 05). The EDD and NEDD in rosuvastatin group on 1m,3m,6m after treatment were significantly better than those in conventional therapy group,moreover,which were significantly better than those before treatment( P <0. 05). Pearson correlation analysis showed that LVEF was positively correlated to EDD,NEDD( r = 0. 741,0. 736,respectively,P < 0. 05). Conclusion Rosuvastatin can improve LVF and EDF of elderly patients with CHD at some extent.
Objective To observe the therapeutic effects of rosuvastatin on left ventricular function( LVF) and endothelium diastolic function( EDF) in elderly patients with coronary heart disease( CHD). Methods One hundred and sixty patients with cardiac insufficiency complicated by unstable angina who were treated in Heyang County Hospital were enrolled in the study. According to different antilipemic agents,the patients were divided into conventional therapy group and rosuvastatin group. The left ventricular ejection fraction( LVEF),left ventricular peak filling rate( LVPFR),endotheliumdependent diastolic function( EDD),non-endothelium-dependent diastolic function( NEDD) were detected before treatment,on 3d,1w,1m,3m,6m after treatment for both groups. Results The LVEF and LVPFR in rosuvastatin group on 1m,3m,6m after treatment were significantly higher than those in conventional therapy group,moreover,which were significantly higher than those before treatment( P < 0. 05). The EDD and NEDD in rosuvastatin group on 1m,3m,6m after treatment were significantly better than those in conventional therapy group,moreover,which were significantly better than those before treatment( P <0. 05). Pearson correlation analysis showed that LVEF was positively correlated to EDD,NEDD( r = 0. 741,0. 736,respectively,P < 0. 05). Conclusion Rosuvastatin can improve LVF and EDF of elderly patients with CHD at some extent.
引文
1王建评.冠心病应用他汀类药物治疗的疗效观察.中西医结合心血管病杂志,2015,3:33-35.
2 Drapkina OM,Eliashavich SO.Efficacy and Safety of Rosuvastatin in Patients of Different Risk Groups of Developing Cardiovascular Diseases.Kardiologiia,2015,55:72-81.
3高艳红,袁俊强,李春生.瑞舒伐他汀钙对急性冠状动脉综合征合并高血脂症患者血脂、CRP及TNF-α的影响.中国实用医刊,2015,42:96-98.
4 Koshel’skaia OA,Vinnitskaia IV,Konko T,et al.Comparative Randomized Study of the Effects of Long-Term Therapy With Rosuvastatin and Combination of Atorvastatin and Ezetimibe on Carbohydrate Metabolism and Adipokines Levels in Patients With Coronary Artery Disease and Diabetes Mellitus.Kardiologiia,2015,55:67-74.
5胡强,刘华勇,梁东.瑞舒伐他汀对不稳定型心绞痛患者血脂及hsCRP、TNF-α水平的影响.中西医结合心血管病杂志,2015,3:134-135.
6 Masuda J,Tanigawa T,Yamada T,et al.Effect of combination therapy of ezetimibe and rosuvastatin on regression of coronary atherosclerosis in patients with coronary artery disease.International heart journal,2015,56:278-285.
7 Ng TW,Ooi EM,Watts GF,et al.Association of Plasma Ceramides and Sphingomyelin With VLDL apoB-100 Fractional Catabolic Rate Before and After Rosuvastatin Treatment.The Journal of clinical endocrinology and metabolism,2015,100:2497-2501.
8王福荣,王治华.瑞舒伐他汀钙治疗老年冠心病合并高脂血症的疗效观察.中西医结合心血管病杂志,2015,3:8-10.
9 Romodanovskii DP,Dranitsyna MA,Goryachev DV,et al.Planning the design and estimating the results of investigayions of bioequivalence of highly variable drugs by example of rosuvastatin.Eksperimental'naia i klinicheskaia farmakologiia,2015,78:19-25.
10张竹林,张丽贞,马秀瑞.瑞舒伐他汀与辅酶Q 10联合应用对急性冠脉综合征患者肝酶及肌痛发生的影响.中西医结合心脑血管病杂志,2015,3:804-806.
11宋燕,王汉杰,苗仁英,等.不同剂量瑞舒伐他汀对动脉粥样硬化大鼠体内脂联素水平的影响.中华实验外科杂志,2015,32:1023-1025.
12张欢,牛蒙蒙,于培明.抗高血脂药瑞舒伐他汀专利现状分析.中国药事,2015,29:702-706.
13郑莉,柳得元,芦海.麝香保心丸对冠心病心绞痛患者血管内皮功能改善作用临床观察.中医药学报,2015,43:113-114.
2 Drapkina OM,Eliashavich SO.Efficacy and Safety of Rosuvastatin in Patients of Different Risk Groups of Developing Cardiovascular Diseases.Kardiologiia,2015,55:72-81.
3高艳红,袁俊强,李春生.瑞舒伐他汀钙对急性冠状动脉综合征合并高血脂症患者血脂、CRP及TNF-α的影响.中国实用医刊,2015,42:96-98.
4 Koshel’skaia OA,Vinnitskaia IV,Konko T,et al.Comparative Randomized Study of the Effects of Long-Term Therapy With Rosuvastatin and Combination of Atorvastatin and Ezetimibe on Carbohydrate Metabolism and Adipokines Levels in Patients With Coronary Artery Disease and Diabetes Mellitus.Kardiologiia,2015,55:67-74.
5胡强,刘华勇,梁东.瑞舒伐他汀对不稳定型心绞痛患者血脂及hsCRP、TNF-α水平的影响.中西医结合心血管病杂志,2015,3:134-135.
6 Masuda J,Tanigawa T,Yamada T,et al.Effect of combination therapy of ezetimibe and rosuvastatin on regression of coronary atherosclerosis in patients with coronary artery disease.International heart journal,2015,56:278-285.
7 Ng TW,Ooi EM,Watts GF,et al.Association of Plasma Ceramides and Sphingomyelin With VLDL apoB-100 Fractional Catabolic Rate Before and After Rosuvastatin Treatment.The Journal of clinical endocrinology and metabolism,2015,100:2497-2501.
8王福荣,王治华.瑞舒伐他汀钙治疗老年冠心病合并高脂血症的疗效观察.中西医结合心血管病杂志,2015,3:8-10.
9 Romodanovskii DP,Dranitsyna MA,Goryachev DV,et al.Planning the design and estimating the results of investigayions of bioequivalence of highly variable drugs by example of rosuvastatin.Eksperimental'naia i klinicheskaia farmakologiia,2015,78:19-25.
10张竹林,张丽贞,马秀瑞.瑞舒伐他汀与辅酶Q 10联合应用对急性冠脉综合征患者肝酶及肌痛发生的影响.中西医结合心脑血管病杂志,2015,3:804-806.
11宋燕,王汉杰,苗仁英,等.不同剂量瑞舒伐他汀对动脉粥样硬化大鼠体内脂联素水平的影响.中华实验外科杂志,2015,32:1023-1025.
12张欢,牛蒙蒙,于培明.抗高血脂药瑞舒伐他汀专利现状分析.中国药事,2015,29:702-706.
13郑莉,柳得元,芦海.麝香保心丸对冠心病心绞痛患者血管内皮功能改善作用临床观察.中医药学报,2015,43:113-114.