基于mDIXON-quant的腰椎骨髓脂肪含量与性别、年龄、体重指数、腰围及内脏脂肪的相关性
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摘要
目的初步探讨基于改良水-脂分离技术(mDIXON-quant)测量腰椎骨髓脂肪含量与性别、年龄、体重指数(BMI)、腰围和内脏脂肪(VAT)的相关性,以加深对腰椎骨髓脂肪含量的认识。方法纳入120例志愿者(女60例,男60例),测量身高、体重,计算BMI,记录腰围,用定量CT(QCT)测量L_3椎体层面的VAT。用mDIXONquant测量L_3椎体骨髓脂肪分数(FF)。对L_3椎体FF值与性别、年龄、BMI、腰围及VAT进行多元线性回归分析;对不同性别组L_3椎体FF值与年龄、BMI、腰围、VAT分别行Pearson相关性分析。结果多元线性回归分析示年龄与椎体FF值关系密切(P <0. 05),性别、BMI、腰围及VAT与椎体FF值均不相关(P> 0. 05)。男女性L_3椎体的FF值比较无统计学差异(t=0. 337,P> 0. 05)。年龄> 50岁以上女性L_3椎体FF值显著高于≤50岁的女性(t=-6. 558,P <0. 05)。女性L_3椎体的FF值与年龄、BMI、腰围、VAT相关(r值分别为0. 715、0. 379、0. 481、0. 507,P<0. 05)。而男性L_3椎体FF值与年龄、BMI、腰围、VAT相关(r值分别为0. 450、0. 323、0. 456、0. 485,P <0. 05)。控制年龄因素后,女性L_3椎体的FF值与BMI、腰围、VAT均不相关(P> 0. 05);男性L_3椎体的FF值仍与BMI、腰围、VAT均相关(r值分别为0. 340、0. 412、0. 391,P <0. 05)。结论女性腰椎骨髓脂肪含量与年龄、BMI、腰围、VAT均相关,但年龄相关性最强。男性腰椎骨髓脂肪含量与年龄、BMI、腰围、VAT均相关,相关性最高的是VAT,其次是腰围,年龄次之。肥胖对男性椎体骨髓脂肪沉积的影响较女性更为明显。
Objective To investigate the correlation between the lumbar vertebral bone marrow fat content and gender,age,body mass index,waistline,and visceral adipose tissue( VAT) by using mDIXON-quant. It may be helpful to deepen the understanding the lumbar vertebral bone marrow fat content. Methods 120 volunteers( 60 males and 60 females)were evaluated for this study. The height,weight and waistline were measured,and the body mass index was calculated.Quantitative CT was also perfomed for the measurement of abdominal visceral adipose tissue( VAT) of L_3. And the measurement of FF values was performed on L_3 vertebrae body by using mDIXON-quant. Multiple linear regression between the FF and the gender,age,body mass index,waistline and visceral adipose tissue( VAT). The correlation between FF of L_3 and age,body mass index,waistline,and visceral adipose tissue( VAT) were analyzed in different genders. Results Multiple linear regression showed the age and FF had significant difference( P < 0. 05),the gender,BMI and VAT had no significant difference( P > 0. 05). The FF of L_3 showed no signifcant difference between males and females( t = 0. 337 P >0. 05). The FF of the age > 50 year-old group was significantly higher than the age ≤50 year-old group( t =-6. 558 P <0. 05) in females. The coefficient of determination between FF and age,body mass index,waistline,and VAT were( r =0. 715,0. 379,0. 481,0. 507,P < 0. 05) in females and( r = 0. 450,0. 323,0. 456,0. 485,P < 0. 05) in males. Controlling the age,there was not correlation between FF and age,body mass index,waistline,and VAT in females( P > 0. 05). And the coefficient of determination between FF and body mass index,waistline,and VAT are( r = 0. 340,0. 412,0. 391,P < 0. 05)in males. Conclusion The lumbar vertebral bone marrow fat content was correlated with age,body mass index,waistline,and visceral adipose tissue both in females and males. The strongest correlation was age in females and visceral adipose tissue,followed by waistline,and age in males. The effect of obesity on bone marrow fat content in males was more obvious than in females.
Objective To investigate the correlation between the lumbar vertebral bone marrow fat content and gender,age,body mass index,waistline,and visceral adipose tissue( VAT) by using mDIXON-quant. It may be helpful to deepen the understanding the lumbar vertebral bone marrow fat content. Methods 120 volunteers( 60 males and 60 females)were evaluated for this study. The height,weight and waistline were measured,and the body mass index was calculated.Quantitative CT was also perfomed for the measurement of abdominal visceral adipose tissue( VAT) of L_3. And the measurement of FF values was performed on L_3 vertebrae body by using mDIXON-quant. Multiple linear regression between the FF and the gender,age,body mass index,waistline and visceral adipose tissue( VAT). The correlation between FF of L_3 and age,body mass index,waistline,and visceral adipose tissue( VAT) were analyzed in different genders. Results Multiple linear regression showed the age and FF had significant difference( P < 0. 05),the gender,BMI and VAT had no significant difference( P > 0. 05). The FF of L_3 showed no signifcant difference between males and females( t = 0. 337 P >0. 05). The FF of the age > 50 year-old group was significantly higher than the age ≤50 year-old group( t =-6. 558 P <0. 05) in females. The coefficient of determination between FF and age,body mass index,waistline,and VAT were( r =0. 715,0. 379,0. 481,0. 507,P < 0. 05) in females and( r = 0. 450,0. 323,0. 456,0. 485,P < 0. 05) in males. Controlling the age,there was not correlation between FF and age,body mass index,waistline,and VAT in females( P > 0. 05). And the coefficient of determination between FF and body mass index,waistline,and VAT are( r = 0. 340,0. 412,0. 391,P < 0. 05)in males. Conclusion The lumbar vertebral bone marrow fat content was correlated with age,body mass index,waistline,and visceral adipose tissue both in females and males. The strongest correlation was age in females and visceral adipose tissue,followed by waistline,and age in males. The effect of obesity on bone marrow fat content in males was more obvious than in females.
引文
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8 Shen W,Chen J,Gantz M,et al. MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults[J]. Eur J Clin Nutr,2012,66:983-988.
9 Li GW,Chang SX,Fan JZ,et al. Marrow adiposity recovery after early zoledronicacid treatment of glucocorticoid-induced bone loss in rabbits assessed by magnetic resonance spectroscopy[J]. Bone,2013,52:668-675.
10 Liney GP,Bemard CP,Manton DJ,et al. Age,gender,and skeletal Variation in bone marrow composition:A preliminary study at 3. 0Tesla[J]. J Magn Reson Imaging,2007,26:787-793.
11 Bredella MA,Torrialli M,Ghomi RH,et al. Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women[J]. Obesity,2011,19:49-53.
12 Hong SC,Yoo SW,Cho GJ,et al. Correlation between estrogens and serum adipocytokines in premenopausal and postmenopausal women[J]. Menopause,2007,14:835-840.
13 Toth MJ,Tchernof A,Sites CK,et al. Menopause-related changes in body fat distribution[J]. Ann N Y Acad Sci,2000,904:502-506.
14 Pedersen SB,Kristensen K,Hermann PA,et al. Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution[J]. J Clin Endocrinol Metab,2004,89:1869-1878.
15 Lange T,Buechert M,Baumstark MW,et al. Value of MRI and MRS fat measurements to complement conventional screening methods for childhood obesity[J]. J Magn Reson Imaging,2015,42:1214-1222.
16 张勇,程晓光,于爱红,等.腰椎椎体骨髓脂肪含量与骨密度、年龄关系的定量影像评估[J].中华放射学杂志,2017,51:771-776.
2 Griffith JF,Yeung DK,Antonio GE,et al. Vertebral bone mineral density,marrow perfusion,and fat content in healthy men and men with osteoporosis:dynamic contrast-enhanced MR imaging and MR spectroscopy[J]. Radiology,2005,236:945-951.
3 Youn Y,Lee HY,Kim JK,et al. Correlation between vertebral marrow fat fraction measured using Dixon quantitative chemical shift MRI and BMD value on dual-energy X-ray absorptiometry[J]. Korean Soc Magn Reson Med,2012,16:16-24.
4 Migliaccio S,Greco EA,Wannenes F,et al. Adipose,bone and muscle tissues as new endocrine organs:role of reciprocal regulation for osteoporosis and obesity development[J]. Horm Mol Biol Clin Investig,2014,17:39-51.
5 Agrawal K,Agarwal Y,Chopra RK,et al. Evaluation of MR spectroscopy and diffusion-weighted MRI in postmenopausal bone strength[J]. Cureus,2015,7:e327.
6 张晓东,赵文吉,陈焱君,等.腹部脂肪及年龄对女性腰椎骨质密度影响协同作用分析[J].中国医学影像学杂志,2016,24:843-846.
7 Schellinger D,Lin CS,Fertikh D,et al. Normal lumbar vertebra:anatomic,age,and sex variance in subjects at proton MR spectroscopyinitial experience[J]. Radiology,2000,215:910-916.
8 Shen W,Chen J,Gantz M,et al. MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults[J]. Eur J Clin Nutr,2012,66:983-988.
9 Li GW,Chang SX,Fan JZ,et al. Marrow adiposity recovery after early zoledronicacid treatment of glucocorticoid-induced bone loss in rabbits assessed by magnetic resonance spectroscopy[J]. Bone,2013,52:668-675.
10 Liney GP,Bemard CP,Manton DJ,et al. Age,gender,and skeletal Variation in bone marrow composition:A preliminary study at 3. 0Tesla[J]. J Magn Reson Imaging,2007,26:787-793.
11 Bredella MA,Torrialli M,Ghomi RH,et al. Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women[J]. Obesity,2011,19:49-53.
12 Hong SC,Yoo SW,Cho GJ,et al. Correlation between estrogens and serum adipocytokines in premenopausal and postmenopausal women[J]. Menopause,2007,14:835-840.
13 Toth MJ,Tchernof A,Sites CK,et al. Menopause-related changes in body fat distribution[J]. Ann N Y Acad Sci,2000,904:502-506.
14 Pedersen SB,Kristensen K,Hermann PA,et al. Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution[J]. J Clin Endocrinol Metab,2004,89:1869-1878.
15 Lange T,Buechert M,Baumstark MW,et al. Value of MRI and MRS fat measurements to complement conventional screening methods for childhood obesity[J]. J Magn Reson Imaging,2015,42:1214-1222.
16 张勇,程晓光,于爱红,等.腰椎椎体骨髓脂肪含量与骨密度、年龄关系的定量影像评估[J].中华放射学杂志,2017,51:771-776.