早盲青少年静息态脑功能磁共振局部一致性及功能连接研究
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摘要
目的探究静息态下早盲青少年大脑局部一致性(ReHo)及功能连接(FC)的变化。方法采集22例早盲青少年(早盲组)及18名年龄、性别匹配的健康志愿者(对照组)静息态功能磁共振成像(rs-fMRI)的数据进行分析,比较两组被试全脑的ReHo差异;将两组间ReHo值差异有统计学意义的脑区作为感兴趣区进行全脑FC分析。分析早盲组有显著差异脑区的ReHo值、FC值与失明持续时间之间的相关性。结果与对照组相比,早盲组左侧距状皮层ReHo值显著降低;左侧楔叶、左侧舌回、左侧小脑前叶FC值显著减低;左侧距状皮层ReHo值,左侧楔叶、左侧舌回、左侧小脑前叶FC值与失明持续时间无明显相关性(P>0.05)。结论早期视觉剥夺可能引起多个高级视觉皮层神经活动异常的现象,这有助于理解早期视觉剥夺后患者的大脑神经功能改变。
Objective To explore the changes of regional homogeneity and functional connectivity of resting brain functional magnetic resonance in early blind adolescents. Methods Twenty-two early blind patients(EB group) and eighteen age-and gender-matched sighted healthy control(HC group) were recruited in this study. They were performed resting-state functional magnetic resonance imaging(rs-fMRI),and regional homogeneity(ReHo)analysis was used to identify the brain areas with significant differences between the two groups. The brain regions with statistically significant differences between two groups of ReHo values were used as the ROI to take functional connectivity(FC) analysis. And the correlation between the ReHo value, FC value of significantly brain regions in EB patients and duration of blindness was investigated respectively. Results Compared with HC group,ReHo values decreased markedly in early blind patients in the left calcarine cortices,and functional connectivity significantly decreased in the left cuneus cortex,left lingual cortex,left cerebellum Anterior lobe in EB group. There were no significant correlations between the duration of blindness and the ReHo values in the left calcarine cortices,and the FC values in the left cuneus cortex, left lingual cortex,left cerebellum Anteriorlobe. Conclusion Early visual deprivation may cause abnormal neural activity in multiple high level visual cortices,which may help to understand the changes in brain neurological function in patients with early visual deprivation.
Objective To explore the changes of regional homogeneity and functional connectivity of resting brain functional magnetic resonance in early blind adolescents. Methods Twenty-two early blind patients(EB group) and eighteen age-and gender-matched sighted healthy control(HC group) were recruited in this study. They were performed resting-state functional magnetic resonance imaging(rs-fMRI),and regional homogeneity(ReHo)analysis was used to identify the brain areas with significant differences between the two groups. The brain regions with statistically significant differences between two groups of ReHo values were used as the ROI to take functional connectivity(FC) analysis. And the correlation between the ReHo value, FC value of significantly brain regions in EB patients and duration of blindness was investigated respectively. Results Compared with HC group,ReHo values decreased markedly in early blind patients in the left calcarine cortices,and functional connectivity significantly decreased in the left cuneus cortex,left lingual cortex,left cerebellum Anterior lobe in EB group. There were no significant correlations between the duration of blindness and the ReHo values in the left calcarine cortices,and the FC values in the left cuneus cortex, left lingual cortex,left cerebellum Anteriorlobe. Conclusion Early visual deprivation may cause abnormal neural activity in multiple high level visual cortices,which may help to understand the changes in brain neurological function in patients with early visual deprivation.
引文
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20张丹.视觉外的关注---盲人导向系统设计[D].南京理工大学,2011.
21 Heine L,Bahri MA,Cavaliere C,et al.Prevalence of increases in functional connectivity in visual,somatosensory and language areas in congenital blindness[J].Frontiers in Neuroanatomy,2015,9.
2 Raz N,Amedi A,Zohary E.V1 activation in congenitally blind humans is associated with episodic retrieval[J].Cerebral Cortex,2005,15:1459-1468.
3 Noppeney U,Friston KJ,Ashburner J,et al.Early visual deprivation induces structural plasticity in gray and white matter[J].Current Biology,2005,15:R488-R490.
4 Zang Y,Jiang T,Lu Y,et al.Regional homogeneity approach to f MRIdata analysis[J].Neuroimage,2004,22:394-400.
5 Constable RT,Scheinost D,Finn ES,et al.Potential use and challenges of functional connectivity mapping in intractable epilepsy[J].Front Neurol,2013,4:39.
6秦文.视觉剥夺后脑结构和功能重构的多模态影像学研究[D].天津医科大学,2013.
7 Wang D,Qin W,Liu Y,et al.Altered white matter integrity in the congenital and late blind people[J].Neural Plast,2013,2013:128236.
8 Shimony JS,Burton H,Epstein AA,et al.Diffusion tensor imaging reveals white matter reorganization in early blind humans[J].Cereb Cortex,2006,16:1653-1661.
9 Lepore N,Voss P,Lepore F,et al.Brain structure changes visualized in early-and late-onset blind subjects[J].Neuroimage,2010,49:134-140.
10 Ptito M,Sohneider FCG,Panlson OB,et al.Alterations of the visual pathways in congenital blindness[J].Experimental Brain Research,2008,187:41-49.
11 Bridge H,Cowey A,Ragge N,et al.Imaging studies in congenital anophthalmia reveal preservation of brain architecture in'visual'cortex[J].Brain,2009,132:3467-3480.
12 Mc Glashan TH,Hoffman RE.Schizophrenia as a disorder of developmentally reduced synaptic connectivity[J].Arch Gen Psychiatry,2000,57:637-648.
13 Hoptman MJ,Zuo XN,Butler PD,et al.Amplitude of low-frequency oscillations in schizophrenia:a resting state f MRI study[J].Schizophr Res,2010,117:13-20.
14 Demirci O,Stevens MC,Andreasen NC,et al.Investigation of relationships between f MRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls[J].Neuroimage,2009,46:419-431.
15 He X,Qin W,Liu Y,et al.Age-related decrease in functional connectivity of the right fronto-insular cortex with the central executive and default-mode networks in adults from young to middle age[J].Neuroscience Letters,2013,544:74-79.
16 Sadato N,Pascual-Leone A,Grafman J,et al.Neural networks for Braille reading by the blind[J].Brain,1998,121:1213-1229.
17 Yu C,Liu Y,Li J,et al.Altered functional connectivity of primary visual cortex in early blindness[J].Hum Brain Mapp,2008,29:533-543.
18 Van Overwalle F,D'Aes T,Marien P.Social Cognition and the Cere bellum:A Meta-Analytic Connectivity Analysis[J].Human Brain Mapping,2015,36:5137-5154.
19 Schmahmann JD,Sherman JC.The cerebellar cognitive affective syndrome[J].Brain,1998,121:561-579.
20张丹.视觉外的关注---盲人导向系统设计[D].南京理工大学,2011.
21 Heine L,Bahri MA,Cavaliere C,et al.Prevalence of increases in functional connectivity in visual,somatosensory and language areas in congenital blindness[J].Frontiers in Neuroanatomy,2015,9.